GB1050401A

GB1050401A – – Google Patents

GB1050401A – – Google Patents

Info

Publication number
GB1050401A

GB1050401A

GB1050401DA
GB1050401A
GB 1050401 A
GB1050401 A
GB 1050401A

GB 1050401D A
GB1050401D A
GB 1050401DA
GB 1050401 A
GB1050401 A
GB 1050401A
Authority
GB
United Kingdom
Prior art keywords
compounds
acid addition
lower alkyl
general formula
products
Prior art date
1900-01-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1963-02-19
Publication date
1900-01-01

1900-01-01
Publication of GB1050401A
publication
Critical
patent/GB1050401A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K31/00—Medicinal preparations containing organic active ingredients

Abstract

1,050,401. Benzodiazepinones. F. HOFFMANN-LA ROCHE & CO. A.G. Feb. 17, 1964 [Feb. 19, 1963], No. 6452/64. Heading C2C. Novel compounds of the general formula (wherein R1 represents -C n H 2n -halogen, in which -C n H 2n – is a straight or branched C 2-7 alkylene group interposing at least two carbon atoms between the N and halogen atoms, R2 represents a lower alkyl group, R3 a halogen atom and R4 a halogen atom, CF 3 or NO 2 , and the broken lines denote that the substituents attached thereby are optional), and their acid addition salts, are prepared by converting the corresponding 1-unsubstituted compounds to their alkali metal derivatives and reacting these with dihalo compounds X-C n H 2n -Z (wherein X and Z represent identical or different halogen atoms) and, if desired, converting the products into acid addition salts. The products may be converted into compounds of the general formula (wherein R represents a lower alkyl group, the curved arrow represents the optional presence of a 4,5-double bond when R is absent, R11 represents -C n H 2n -N(RaRb) in which Ra and Rb are lower alkyl groups which may be joined directly or through O or N (the latter optionally carrying a lower alkyl, lower hydroxyalkyl, lower alkoxyalkyl or-in 4,5-unsaturated compounds-a lower alkenyloxyalkyl radical) to form, with the N atom to which they are attached, a 5- or 6-membered heterocyclic ring, and R40 represents a halogen atom, CF 3 or-in 4,5-unsaturated compounds-NO 2 ) by the further step or steps of reaction with a secondary amine HN(Ra)(Rb) and, optionally, catalytic hydrogenation of the 4,5-double bond (when no NO 2 group is present), and alkylation of the reduction product, and/or introduction of one of the specified substituents into a diaza ring forming the -N(Ra)(Rb) substituent, and/or conversion of the products into acid addition or quaternary salts. (The term ” lower ‘ indicates that radicals so qualified contain not more than 7 carbon atoms). Pharmaceutical preparations having anticonvulsant, analgesic, sedative and muscle relaxant activity comprise a compound of the first general formula above or a pharmaceutically acceptable acid addition salt thereof in admixture with a compatible pharmaceutical organic or inorganic solid or liquid carrier suitable for enteral or parenteral administration.

GB1050401D
1963-02-19

Expired

GB1050401A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

US25975363A

1963-02-19
1963-02-19

Publications (1)

Publication Number
Publication Date

GB1050401A
true

GB1050401A
(en)

1900-01-01

Family
ID=22986219
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB1050401D
Expired

GB1050401A
(en)

1963-02-19

Country Status (12)

Country
Link

BE
(1)

BE643885A
(en)

BR
(1)

BR6456904D0
(en)

CH
(1)

CH449031A
(en)

DE
(1)

DE1445888A1
(en)

DK
(1)

DK111004B
(en)

ES
(1)

ES296566A1
(en)

FR
(2)

FR1388222A
(en)

GB
(1)

GB1050401A
(en)

NL
(1)

NL142958B
(en)

NO
(1)

NO118706B
(en)

OA
(1)

OA02392A
(en)

SE
(2)

SE319483B
(en)

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

FR2444672A1
(en)

*

1978-12-18
1980-07-18
Gerot Pharmazeutika

3-HYDROXY-1,4-BENZODIAZEPIN-2-ONE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION

0

GB
GB1050401D
patent/GB1050401A/en
not_active
Expired

1964

1964-01-31
CH
CH114264A
patent/CH449031A/en
unknown

1964-02-04
DE
DE19641445888
patent/DE1445888A1/en
active
Pending

1964-02-14
NL
NL646401335A
patent/NL142958B/en
not_active
IP Right Cessation

1964-02-17
FR
FR963971A
patent/FR1388222A/en
not_active
Expired

1964-02-17
FR
FR963972A
patent/FR3253M/fr
active
Active

1964-02-17
BE
BE643885D
patent/BE643885A/xx
unknown

1964-02-18
NO
NO15206464A
patent/NO118706B/no
unknown

1964-02-18
ES
ES296566A
patent/ES296566A1/en
not_active
Expired

1964-02-18
BR
BR15690464A
patent/BR6456904D0/en
unknown

1964-02-19
DK
DK80564A
patent/DK111004B/en
unknown

1964-02-19
SE
SE200264A
patent/SE319483B/xx
unknown

1966

1966-02-21
SE
SE222966A
patent/SE319773B/xx
unknown

1967

1967-03-30
OA
OA52857A
patent/OA02392A/en
unknown

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

FR2444672A1
(en)

*

1978-12-18
1980-07-18
Gerot Pharmazeutika

3-HYDROXY-1,4-BENZODIAZEPIN-2-ONE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION

Also Published As

Publication number
Publication date

BR6456904D0
(en)

1973-08-09

NL142958B
(en)

1974-08-15

DE1445888A1
(en)

1968-12-19

NL6401335A
(en)

1964-08-20

FR1388222A
(en)

1965-02-05

SE319773B
(en)

1970-01-26

NO118706B
(en)

1970-02-02

SE319483B
(en)

1970-01-19

DK111004B
(en)

1968-04-29

FR3253M
(en)

1965-04-20

ES296566A1
(en)

1964-08-16

OA02392A
(en)

1970-05-05

BE643885A
(en)

1964-08-17

CH449031A
(en)

1967-12-31

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