GB1064893A

GB1064893A – Process for the preparation of penicillins
– Google Patents

GB1064893A – Process for the preparation of penicillins
– Google Patents
Process for the preparation of penicillins

Info

Publication number
GB1064893A

GB1064893A
GB12138/65A
GB1213865A
GB1064893A
GB 1064893 A
GB1064893 A
GB 1064893A
GB 12138/65 A
GB12138/65 A
GB 12138/65A
GB 1213865 A
GB1213865 A
GB 1213865A
GB 1064893 A
GB1064893 A
GB 1064893A
Authority
GB
United Kingdom
Prior art keywords
formula
aralkyl
substituted
carbon atoms
unsubstituted alkyl
Prior art date
1965-03-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB12138/65A
Inventor
Brian William Hatt
Harry Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Beecham Group PLC

Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1965-03-23
Filing date
1965-03-23
Publication date
1967-04-12

1965-03-23
Application filed by Beecham Group PLC
filed
Critical
Beecham Group PLC

1965-03-23
Priority to GB12138/65A
priority
Critical
patent/GB1064893A/en

1966-03-11
Priority to BR177772/66A
priority
patent/BR6677772D0/en

1966-03-16
Priority to NL6603463A
priority
patent/NL6603463A/xx

1966-03-17
Priority to AT254966A
priority
patent/AT268517B/en

1966-03-21
Priority to CH405266A
priority
patent/CH473835A/en

1966-03-21
Priority to DE19661670063
priority
patent/DE1670063A1/en

1966-03-21
Priority to ES0324454A
priority
patent/ES324454A1/en

1966-03-21
Priority to DE19661795533
priority
patent/DE1795533A1/en

1966-03-22
Priority to FR54405A
priority
patent/FR1472473A/en

1966-03-23
Priority to BE678304D
priority
patent/BE678304A/xx

1967-04-12
Publication of GB1064893A
publication
Critical
patent/GB1064893A/en

1969-05-22
Priority to US828435A
priority
patent/US3553202A/en

Status
Expired
legal-status
Critical
Current

Links

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Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

A—HUMAN NECESSITIES

A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES

A23K—FODDER

A23K20/00—Accessory food factors for animal feeding-stuffs

A23K20/10—Organic substances

A23K20/195—Antibiotics

Abstract

Penicillins of Formula I and non-toxic salts thereof, wherein R is a substituted or unsubstituted alkyl, aralkyl, aryl or heterocyclic group, are prepared by reacting with a basic reagent a N-protected penicillin of Formula II wherein R is as above, X is a divalent saturated hydrocarbon radical containing 2 to 6 carbon atoms linked to the groups on either side through adjacent carbon atoms and R1 is a substituted or unsubstituted alkyl, aralkyl or aryl group or a non-toxic salt thereof. Preferably X is ethylene and R1 is p-tolyl, e.g. 6-[D-a -(2-p-toluene sulphonyl ethoxycarbonylamino) – a – phenylacetamido] penicillanic acid. The reaction may be carried out in an aqueous solution of pH 8-11.5, using a base such as a tertiary aliphatic amine. Alternatively, the N-protected penicillin (II) may be treated with an alkali metal hydroxide or alkoxide or metalloorganic compound in an anhydrous organic solvent to produce a carbamate salt of formula where M is a metal radical, which is then converted to the aminopenicillin (I) by treatment with acid.

GB12138/65A
1965-03-23
1965-03-23
Process for the preparation of penicillins

Expired

GB1064893A
(en)

Priority Applications (11)

Application Number
Priority Date
Filing Date
Title

GB12138/65A

GB1064893A
(en)

1965-03-23
1965-03-23
Process for the preparation of penicillins

BR177772/66A

BR6677772D0
(en)

1965-03-23
1966-03-11

A PROCESS FOR PENICILLIN PREPARATION

NL6603463A

NL6603463A
(en)

1965-03-23
1966-03-16

AT254966A

AT268517B
(en)

1965-03-23
1966-03-17

Process for the production of penicillins

DE19661670063

DE1670063A1
(en)

1965-03-23
1966-03-21

Process for the production of penicillins

CH405266A

CH473835A
(en)

1965-03-23
1966-03-21

Process for the production of penicillins

ES0324454A

ES324454A1
(en)

1965-03-23
1966-03-21
A procedure for the preparation of penicillins. (Machine-translation by Google Translate, not legally binding)

DE19661795533

DE1795533A1
(en)

1965-03-23
1966-03-21

Penicillins with a protected amino group, their non-toxic salts and their use for the production of other penicillins

FR54405A

FR1472473A
(en)

1965-03-23
1966-03-22

Process for the preparation of penicillins

BE678304D

BE678304A
(en)

1965-03-23
1966-03-23

US828435A

US3553202A
(en)

1965-03-23
1969-05-22
Production of aminoacylpenicillins

Applications Claiming Priority (2)

Application Number
Priority Date
Filing Date
Title

GB12138/65A

GB1064893A
(en)

1965-03-23
1965-03-23
Process for the preparation of penicillins

GB3047965

1965-07-17

Publications (1)

Publication Number
Publication Date

GB1064893A
true

GB1064893A
(en)

1967-04-12

Family
ID=26248808
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB12138/65A
Expired

GB1064893A
(en)

1965-03-23
1965-03-23
Process for the preparation of penicillins

Country Status (9)

Country
Link

US
(1)

US3553202A
(en)

BE
(1)

BE678304A
(en)

BR
(1)

BR6677772D0
(en)

CH
(1)

CH473835A
(en)

DE
(2)

DE1795533A1
(en)

ES
(1)

ES324454A1
(en)

FR
(1)

FR1472473A
(en)

GB
(1)

GB1064893A
(en)

NL
(1)

NL6603463A
(en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US3669978A
(en)

*

1970-05-28
1972-06-13
American Home Prod
Process for the production of semi-synthetic penicillin intermediate

1965

1965-03-23
GB
GB12138/65A
patent/GB1064893A/en
not_active
Expired

1966

1966-03-11
BR
BR177772/66A
patent/BR6677772D0/en
unknown

1966-03-16
NL
NL6603463A
patent/NL6603463A/xx
unknown

1966-03-21
DE
DE19661795533
patent/DE1795533A1/en
active
Pending

1966-03-21
DE
DE19661670063
patent/DE1670063A1/en
active
Pending

1966-03-21
CH
CH405266A
patent/CH473835A/en
not_active
IP Right Cessation

1966-03-21
ES
ES0324454A
patent/ES324454A1/en
not_active
Expired

1966-03-22
FR
FR54405A
patent/FR1472473A/en
not_active
Expired

1966-03-23
BE
BE678304D
patent/BE678304A/xx
unknown

1969

1969-05-22
US
US828435A
patent/US3553202A/en
not_active
Expired – Lifetime

Also Published As

Publication number
Publication date

DE1670063A1
(en)

1970-10-29

CH473835A
(en)

1969-06-15

DE1795533A1
(en)

1972-01-27

US3553202A
(en)

1971-01-05

ES324454A1
(en)

1967-02-01

NL6603463A
(en)

1966-09-26

FR1472473A
(en)

1967-03-10

BE678304A
(en)

1966-09-23

BR6677772D0
(en)

1973-09-11

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In PTB • ML; '- ^' '•' ^ ^ "^ – ^ Tf:? ^ Research Institute for Organic Intermediates and Dyes

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(en)

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Method for preparing o, o-dialkyl- (2-aminoethyl) dithiophosphates

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(en)

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(en)

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(en)

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(en)

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(en)

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(en)

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