GB1084793A

GB1084793A – Novel basic ethers and pharmaceutical compositions containing the same
– Google Patents

GB1084793A – Novel basic ethers and pharmaceutical compositions containing the same
– Google Patents
Novel basic ethers and pharmaceutical compositions containing the same

Info

Publication number
GB1084793A

GB1084793A
GB3495264A
GB3495264A
GB1084793A
GB 1084793 A
GB1084793 A
GB 1084793A
GB 3495264 A
GB3495264 A
GB 3495264A
GB 3495264 A
GB3495264 A
GB 3495264A
GB 1084793 A
GB1084793 A
GB 1084793A
Authority
GB
United Kingdom
Prior art keywords
group
halo
substituents
methyl
same
Prior art date
1963-08-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB3495264A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

CH Boehringer Sohn AG and Co KG

Boehringer Ingelheim GmbH

Original Assignee
CH Boehringer Sohn AG and Co KG
Boehringer Ingelheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1963-08-26
Filing date
1964-08-26
Publication date
1967-09-27

1964-08-26
Application filed by CH Boehringer Sohn AG and Co KG, Boehringer Ingelheim GmbH
filed
Critical
CH Boehringer Sohn AG and Co KG

1967-09-27
Publication of GB1084793A
publication
Critical
patent/GB1084793A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K31/00—Medicinal preparations containing organic active ingredients

A61K31/13—Amines

A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline

Abstract

Compounds of the formula and their non-toxic salts in which R represents a halogen atom, a straight- or branched chain 1-4C alkyl or alkoxy group a 2-4C acyl group, a nitro, amino, hydroxy, cyano or aralkoxy group or a methylene dioxy group substituting the benzene ring in two adjacent positions; x is 1,2 or 3 and R, when x is 2 or 3 represent the same or different groups, except that, when x is 1, R cannot be an o-halo, o-methoxy or o-methyl group and when x is 2 both substituents R cannot represent methyl groups in the 2- and 6-position respectively are prepared by the reaction of isopropylamine with (a) an epoxide. or (b) a halo compound or an amine with an isopropyl halide; or a phenolate where M is a monovalent cation, with a 1-halo-2-hydroxy – 3 – isopropylaminopropane, or hy drogenation of an amide (except where R is NO2) or reduction of an amino ketone or by the hydrolysis of an oxazolidone ALSO:Pharmaceutical compositions comprise as an active ingredient at least one compound of the formula (A) (in which R is a halogen atom, a straight or branched-chain alkyl or alkoxy group of 1-4C, an acyl group of 2-4C, NO2, NH2, OH, CN, or an aralkoxy group or a methylenedioxy group; x is 1-3, and the substituents R, when x is 2 or 3 are the same or different groups providing that when x is 1, R cannot be a o-halo, o-methyl or o-methoxy group and when x is 2 both the substituents R cannot be methyl groups in the 2- and 6-positions respectively) together with a carrier or diluent. The compositions which induce bradycardia and antagonise N-isopropyl noradiehalin may be formulated for oral parenteral or rectal administration.

GB3495264A
1963-08-26
1964-08-26
Novel basic ethers and pharmaceutical compositions containing the same

Expired

GB1084793A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

DE1963B0073262

DE1493454C3
(en)

1963-08-26
1963-08-26

1 -Aryloxy ^ -hydroxy-S-isopropylaminopropane and their salts, as well as their production and pharmaceuticals based thereon

Publications (1)

Publication Number
Publication Date

GB1084793A
true

GB1084793A
(en)

1967-09-27

Family
ID=6977785
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB3495264A
Expired

GB1084793A
(en)

1963-08-26
1964-08-26
Novel basic ethers and pharmaceutical compositions containing the same

Country Status (13)

Country
Link

JP
(5)

JPS509780B1
(en)

BE
(1)

BE652336A
(en)

BR
(1)

BR6462130D0
(en)

CH
(6)

CH540225A
(en)

CY
(1)

CY572A
(en)

DE
(1)

DE1493454C3
(en)

DK
(4)

DK129411B
(en)

FI
(2)

FI43881C
(en)

FR
(2)

FR3647M
(en)

GB
(1)

GB1084793A
(en)

IL
(1)

IL21978A
(en)

NL
(2)

NL142950B
(en)

SE
(6)

SE346775B
(en)

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US4252825A
(en)

*

1974-06-28
1981-02-24
C. M. Industries
Compositions for treatment of cardiovascular conditions associated with overproduction of catecholamines

Families Citing this family (7)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

DE881436C
(en)

*

1938-12-04
1953-06-29
Ind G M B H

Device for removing the dust thrown off by bag filters

US3466325A
(en)

*

1965-04-30
1969-09-09
Haessle Ab
1-(ortho-alkenyl phenoxy) – 2-hydroxy-3-isopropylaminopropanes and the salts thereof

US3868460A
(en)

*

1967-02-06
1975-02-25
Boehringer Sohn Ingelheim
Therapeutic compositions and method

US3541130A
(en)

*

1967-02-06
1970-11-17
Boehringer Sohn Ingelheim
1-(cyanophenoxy)-2-hydroxy-3-tert.-butylamine propanes

JPS5418240U
(en)

*

1977-07-07
1979-02-06

JPS54133863U
(en)

*

1978-03-08
1979-09-17

DE2839475A1
(en)

*

1978-09-11
1980-03-20
Dolorgiet Arzneimittelfabrik

ISOPROPYLAMINE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THE SAME

1963

1963-08-26
DE
DE1963B0073262
patent/DE1493454C3/en
not_active
Expired

1964

1964-08-25
CH
CH764973A
patent/CH540225A/en
not_active
IP Right Cessation

1964-08-25
CH
CH1109264A
patent/CH539606A/en
not_active
IP Right Cessation

1964-08-25
CH
CH765073A
patent/CH539607A/en
not_active
IP Right Cessation

1964-08-25
CH
CH765273A
patent/CH539609A/en
not_active
IP Right Cessation

1964-08-25
CH
CH765173A
patent/CH539608A/en
not_active
IP Right Cessation

1964-08-25
CH
CH765373A
patent/CH539610A/en
not_active
IP Right Cessation

1964-08-26
JP
JP4838064A
patent/JPS509780B1/ja
active
Pending

1964-08-26
FI
FI182164A
patent/FI43881C/en
active

1964-08-26
BR
BR16213064A
patent/BR6462130D0/en
unknown

1964-08-26
FR
FR986265A
patent/FR3647M/en
not_active
Expired

1964-08-26
SE
SE129268A
patent/SE346775B/xx
unknown

1964-08-26
NL
NL6409883A
patent/NL142950B/en
not_active
IP Right Cessation

1964-08-26
IL
IL2197864A
patent/IL21978A/en
unknown

1964-08-26
DK
DK421664A
patent/DK129411B/en
unknown

1964-08-26
SE
SE10240/64A
patent/SE318891B/xx
unknown

1964-08-26
FR
FR1555463D
patent/FR1555463A/fr
not_active
Expired

1964-08-26
GB
GB3495264A
patent/GB1084793A/en
not_active
Expired

1964-08-26
BE
BE652336A
patent/BE652336A/xx
unknown

1967

1967-03-31
DK
DK185167A
patent/DK112739B/en
unknown

1967-07-07
JP
JP4341467A
patent/JPS5021454B1/ja
active
Pending

1967-07-07
JP
JP4341367A
patent/JPS509782B1/ja
active
Pending

1967-07-07
JP
JP4341567A
patent/JPS507047B1/ja
active
Pending

1967-07-07
JP
JP4341167A
patent/JPS509781B1/ja
active
Pending

1968

1968-01-31
SE
SE01295/68A
patent/SE346779B/xx
unknown

1968-01-31
SE
SE01293/68A
patent/SE346776B/xx
unknown

1968-01-31
SE
SE01296/68A
patent/SE346777B/xx
unknown

1968-01-31
SE
SE01294/68A
patent/SE346778B/xx
unknown

1969

1969-09-22
FI
FI269869A
patent/FI52974C/fi
active

1970

1970-12-07
NL
NL7017830A
patent/NL7017830A/en
unknown

1971

1971-01-16
CY
CY57271A
patent/CY572A/en
unknown

1971-06-01
DK
DK267371A
patent/DK129032B/en
unknown

1972

1972-11-29
DK
DK596872A
patent/DK131988C/en
active

Cited By (2)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US4302601A
(en)

*

1974-02-28
1981-11-24
C M Industries
Aromatic ketones having cardiovascular activity

US4252825A
(en)

*

1974-06-28
1981-02-24
C. M. Industries
Compositions for treatment of cardiovascular conditions associated with overproduction of catecholamines

Also Published As

Publication number
Publication date

FI52974C
(en)

1978-01-10

FI43881C
(en)

1971-07-12

DE1493454C3
(en)

1980-04-30

DK129411B
(en)

1974-10-07

DK131988C
(en)

1976-03-01

FR1555463A
(en)

1969-01-31

SE346775B
(en)

1972-07-17

JPS509781B1
(en)

1975-04-16

SE346778B
(en)

1972-07-17

CH539607A
(en)

1973-07-31

DK129032B
(en)

1974-08-12

NL6409883A
(en)

1965-03-01

SE346779B
(en)

1972-07-17

SE346776B
(en)

1972-07-17

JPS509782B1
(en)

1975-04-16

NL142950B
(en)

1974-08-15

CH539608A
(en)

1973-07-31

NL7017830A
(en)

1971-03-25

CH540225A
(en)

1973-08-15

CH539606A
(en)

1973-07-31

CH539609A
(en)

1973-07-31

SE318891B
(en)

1969-12-22

DK112739B
(en)

1969-01-13

DE1493454A1
(en)

1969-05-29

CH539610A
(en)

1973-07-31

JPS507047B1
(en)

1975-03-20

JPS5021454B1
(en)

1975-07-23

FI43881B
(en)

1971-03-31

BR6462130D0
(en)

1973-08-02

DE1493454B2
(en)

1979-08-09

JPS509780B1
(en)

1975-04-16

FR3647M
(en)

1965-10-25

SE346777B
(en)

1972-07-17

BE652336A
(en)

1965-02-26

DK129411C
(en)

1975-02-24

IL21978A
(en)

1968-01-25

DK131988B
(en)

1975-10-06

FI52974B
(en)

1977-09-30

CY572A
(en)

1971-01-16

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