GB1107470A

GB1107470A – Basic esters and a process for their production
– Google Patents

GB1107470A – Basic esters and a process for their production
– Google Patents
Basic esters and a process for their production

Info

Publication number
GB1107470A

GB1107470A
GB54090/66A
GB5409066A
GB1107470A
GB 1107470 A
GB1107470 A
GB 1107470A
GB 54090/66 A
GB54090/66 A
GB 54090/66A
GB 5409066 A
GB5409066 A
GB 5409066A
GB 1107470 A
GB1107470 A
GB 1107470A
Authority
GB
United Kingdom
Prior art keywords
bis
homopiperazine
hydroxypropyl
prepared
compound
Prior art date
1965-12-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB54090/66A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

ASTA-WERKE AG

Asta Medica GmbH

Original Assignee
ASTA-WERKE AG
Asta Werke AG Chemische Fabrik
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1965-12-16
Filing date
1966-12-02
Publication date
1968-03-27

1966-12-02
Application filed by ASTA-WERKE AG, Asta Werke AG Chemische Fabrik
filed
Critical
ASTA-WERKE AG

1968-03-27
Publication of GB1107470A
publication
Critical
patent/GB1107470A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms

C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms

C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K31/00—Medicinal preparations containing organic active ingredients

A61K31/33—Heterocyclic compounds

A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins

A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms

C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4

C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms

C07D245/02—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms not condensed with other rings

Abstract

Novel basic esters (and acid addition salts thereof), of the general formula wherein R is an alkoxy group with 1 to 4 carbon atoms, n is 1, 2 or 3, m is 2 or 3, x is 2, 3 or 4, y is 2 or 3 and x together with y is from 5 to 7, are prepared by the interaction of: (a) a N,N1-bis-o -hydroxyalkyl compound containing the desired heterocyclic nucleus with an alkoxy substituted benzoyl halide, (b) a N,N1-bis-omega -halogenoalkyl compound having the desired heterocyclic nucleus with an alkali or silver salt of an alkoxy substituted benzoic acid, or (c) the desired unsubstituted heterocyclic compound and the desired haloalkyl benzoate. N,N1 – bis – (3 – hydroxypropyl) homopiperazine, N,N1 – bis – (3 – bromopropyl) homopiperazine dihydrobromide and N,N1 – bis – (3 -hydroxypropyl) – 1,5 – diazacyclooctane are prepared by reacting the desired diamine and dihalopropane. Pharmaceutical compositions which produce coronary dilatation contain as the active ingredient the above novel compounds and are administered intravenously and orally.

GB54090/66A
1965-12-16
1966-12-02
Basic esters and a process for their production

Expired

GB1107470A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

DE1965A0051095

DE1545575C2
(en)

1965-12-16
1965-12-16

N, N’-Bis- square bracket to 3 “(3 ‘, 4′, 5’-trimethoxybenzoyloxy) -propyl square bracket to -homopiperazine

Publications (1)

Publication Number
Publication Date

GB1107470A
true

GB1107470A
(en)

1968-03-27

Family
ID=6937763
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB54090/66A
Expired

GB1107470A
(en)

1965-12-16
1966-12-02
Basic esters and a process for their production

Country Status (14)

Country
Link

US
(1)

US3532685A
(en)

AT
(1)

AT275527B
(en)

BE
(1)

BE691016A
(en)

CH
(1)

CH476742A
(en)

CS
(1)

CS191151B2
(en)

DE
(1)

DE1545575C2
(en)

DK
(1)

DK113291B
(en)

ES
(1)

ES334393A1
(en)

FR
(1)

FR6053M
(en)

GB
(1)

GB1107470A
(en)

IL
(1)

IL27013A
(en)

MY
(1)

MY7100027A
(en)

NL
(1)

NL153537B
(en)

SE
(1)

SE317977B
(en)

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

EP0170361A1
(en)

*

1984-06-06
1986-02-05
Kowa Company, Ltd.
Antiatherosclerotic agents

Families Citing this family (11)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US3980643A
(en)

*

1974-01-04
1976-09-14
Hokuriku Pharmaceutical Co., Ltd.
Novel piperazine- and homopiperazine-monoalkanol esters and a process of production thereof

US4035494A
(en)

*

1975-10-20
1977-07-12
Sandoz, Inc.
Bis-p-pivaloyl benzylamines

DE3403778A1
(en)

*

1984-02-03
1985-08-08
Degussa Ag, 6000 Frankfurt

CYANOMETHYL- (2-CYANO-ETHYL) – (3-HYDROXY-PROPYL) -AMINE HIS USE FOR PRODUCING 1- (3-HYDROXY-PROPYL) -1,4-DIAZEPANE AND 1,4-BIS (3- (3rd , 4,5-TRIMETHOXYBENZOYLOXY) -PROPYL) -DIAZEPAN

DE3438289A1
(en)

*

1984-10-19
1986-04-24
Degussa Ag, 6000 Frankfurt
Process for purifying dilazep base

GEP20074134B
(en)

2002-08-19
2007-06-25
Pfizer Prod Inc
Combination therapy for hyperproliferative diseases

US20060063803A1
(en)

*

2004-09-23
2006-03-23
Pfizer Inc
4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds

US7741317B2
(en)

2005-10-21
2010-06-22
Bristol-Myers Squibb Company
LXR modulators

US7888376B2
(en)

2005-11-23
2011-02-15
Bristol-Myers Squibb Company
Heterocyclic CETP inhibitors

EP2094643B1
(en)

2006-12-01
2012-02-29
Bristol-Myers Squibb Company
N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases

KR101695582B1
(en)

2013-04-17
2017-01-13
화이자 인코포레이티드
N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases

WO2016055901A1
(en)

2014-10-08
2016-04-14
Pfizer Inc.
Substituted amide compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

BE629910A
(en)

*

1962-03-22

DE1182239B
(en)

*

1962-04-02
1964-11-26
Lentia Gmbh

Process for the preparation of piperazine derivatives

1965

1965-12-16
DE
DE1965A0051095
patent/DE1545575C2/en
not_active
Expired

1966

1966-12-01
DK
DK620966AA
patent/DK113291B/en
unknown

1966-12-02
GB
GB54090/66A
patent/GB1107470A/en
not_active
Expired

1966-12-05
AT
AT1120566A
patent/AT275527B/en
active

1966-12-05
IL
IL27013A
patent/IL27013A/en
unknown

1966-12-07
US
US599724A
patent/US3532685A/en
not_active
Expired – Lifetime

1966-12-10
ES
ES0334393A
patent/ES334393A1/en
not_active
Expired

1966-12-12
BE
BE691016D
patent/BE691016A/xx
not_active
IP Right Cessation

1966-12-12
SE
SE17000/66A
patent/SE317977B/xx
unknown

1966-12-14
CS
CS668008A
patent/CS191151B2/en
unknown

1966-12-15
CH
CH1789566A
patent/CH476742A/en
not_active
IP Right Cessation

1966-12-15
NL
NL666617653A
patent/NL153537B/en
not_active
IP Right Cessation

1966-12-16
FR
FR87720A
patent/FR6053M/fr
not_active
Expired

1971

1971-12-31
MY
MY197127A
patent/MY7100027A/en
unknown

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

EP0170361A1
(en)

*

1984-06-06
1986-02-05
Kowa Company, Ltd.
Antiatherosclerotic agents

Also Published As

Publication number
Publication date

DK113291B
(en)

1969-03-10

MY7100027A
(en)

1971-12-31

US3532685A
(en)

1970-10-06

NL6617653A
(en)

1967-06-19

BE691016A
(en)

1967-06-12

CH476742A
(en)

1969-08-15

NL153537B
(en)

1977-06-15

IL27013A
(en)

1970-07-19

DE1545575B1
(en)

1970-02-05

DE1545575C2
(en)

1970-09-10

ES334393A1
(en)

1967-11-01

FR6053M
(en)

1968-05-20

SE317977B
(en)

1969-12-01

AT275527B
(en)

1969-10-27

CS191151B2
(en)

1979-06-29

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