GB1112347A – Salts of organic bases with n-carbamyl-l-glutamic acid
– Google Patents
GB1112347A – Salts of organic bases with n-carbamyl-l-glutamic acid
– Google Patents
Salts of organic bases with n-carbamyl-l-glutamic acid
Info
Publication number
GB1112347A
GB1112347A
GB3590065A
GB3590065A
GB1112347A
GB 1112347 A
GB1112347 A
GB 1112347A
GB 3590065 A
GB3590065 A
GB 3590065A
GB 3590065 A
GB3590065 A
GB 3590065A
GB 1112347 A
GB1112347 A
GB 1112347A
Authority
GB
United Kingdom
Prior art keywords
carbamyl
lysine
glutamic acid
acid
salt
Prior art date
1965-08-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3590065A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1965-08-20
Filing date
1965-08-20
Publication date
1968-05-01
1965-08-20
Application filed by Individual
filed
Critical
Individual
1965-08-20
Priority to GB3590065A
priority
Critical
patent/GB1112347A/en
1968-05-01
Publication of GB1112347A
publication
Critical
patent/GB1112347A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
Abstract
The invention comprises the salts of N-carbamyl-l-glumatic acid with organic bases other than lysine, the neutral salt of N-carbamyl-l-glutamic acid with lysine and the acid salt of N-carbamyl-l-glutamic acid with lysine in the pure state having a melting point of 191-3 DEG C. and an optical rotation of +11.7 DEG , which are prepared by salifying the acid with the appropriate organic base in an aqueous or alcoholic medium at room temperature or at about 80-90 DEG C. Suitable organic bases mentioned are morpholine, methylglucamine, amphetamine, pyridoxine, choline, arginine, ornithine, piperazine, dimethylaminoethanol and di-isopropylamine.ALSO:The invention comprises pharmaceutical compositions comprising as active ingredient a salt of N-carbamyl-l-glutamic acid with an organic base other than lysine, or the neutral salt of N-carbamyl-l-glutamic acid with lysine, and also pharmaceutical compositions in the form of a sterile injectable solution, suppository, tablet or capsule comprising as active ingredient the acid salt of N-carbamyl-l-glutamic acid with lysine. The compounds possess, in general, a hepatotropic effect and one or more of the following properties:- a favourable effect on growth, a restorative and regenerative action, a reducing effect on hyperammoniaemia, a neuro-regulating and neuro-stimulating action and an anti-fatigue action.
GB3590065A
1965-08-20
1965-08-20
Salts of organic bases with n-carbamyl-l-glutamic acid
Expired
GB1112347A
(en)
Priority Applications (1)
Application Number
Priority Date
Filing Date
Title
GB3590065A
GB1112347A
(en)
1965-08-20
1965-08-20
Salts of organic bases with n-carbamyl-l-glutamic acid
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
GB3590065A
GB1112347A
(en)
1965-08-20
1965-08-20
Salts of organic bases with n-carbamyl-l-glutamic acid
Publications (1)
Publication Number
Publication Date
GB1112347A
true
GB1112347A
(en)
1968-05-01
Family
ID=10382790
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB3590065A
Expired
GB1112347A
(en)
1965-08-20
1965-08-20
Salts of organic bases with n-carbamyl-l-glutamic acid
Country Status (1)
Country
Link
GB
(1)
GB1112347A
(en)
Cited By (15)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US7105486B2
(en)
2002-02-22
2006-09-12
New River Pharmaceuticals Inc.
Abuse-resistant amphetamine compounds
US7223735B2
(en)
2003-05-29
2007-05-29
New River Pharmaceuticals Inc.
Abuse resistant lysine amphetamine compounds
WO2008004610A1
(en)
*
2006-07-05
2008-01-10
The University Of Tokyo
Method of treating genetic disease caused by nonsense mutation
US7375083B2
(en)
2003-09-30
2008-05-20
Shire Llc
Pharmaceutical compositions for prevention of overdose or abuse
US7427600B2
(en)
2000-08-22
2008-09-23
Shire Llc
Active agent delivery systems and methods for protecting and administering active agents
US7622441B2
(en)
2002-02-22
2009-11-24
Shire Llc
Sustained release pharmaceutical compounds to prevent abuse of controlled substances
US7655630B2
(en)
2002-02-22
2010-02-02
Shire Llc
Abuse-resistant amphetamine prodrugs
US7659253B2
(en)
2002-02-22
2010-02-09
Shire Llc
Abuse-resistant amphetamine prodrugs
WO2011160259A1
(en)
*
2010-06-24
2011-12-29
上海永颐生物科技有限公司
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US8106016B2
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CN108017561A
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2016-11-04
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武汉武药科技有限公司
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2016-11-22
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RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a.
Pharmaceutical parenteral formulation containing carglumic acid
CN112028794A
(en)
*
2019-06-03
2020-12-04
武汉武药科技有限公司
High-purity kaglutamic acid and preparation method thereof
1965
1965-08-20
GB
GB3590065A
patent/GB1112347A/en
not_active
Expired
Cited By (35)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US7427600B2
(en)
2000-08-22
2008-09-23
Shire Llc
Active agent delivery systems and methods for protecting and administering active agents
US8394813B2
(en)
2000-11-14
2013-03-12
Shire Llc
Active agent delivery systems and methods for protecting and administering active agents
US8343927B2
(en)
2001-08-22
2013-01-01
Shire Llc
Pharmaceutical compositions for prevention of overdose or abuse
US7659253B2
(en)
2002-02-22
2010-02-09
Shire Llc
Abuse-resistant amphetamine prodrugs
US7671030B2
(en)
2002-02-22
2010-03-02
Shire Llc
Abuse-resistant amphetamine prodrugs
US7622441B2
(en)
2002-02-22
2009-11-24
Shire Llc
Sustained release pharmaceutical compounds to prevent abuse of controlled substances
US7655630B2
(en)
2002-02-22
2010-02-02
Shire Llc
Abuse-resistant amphetamine prodrugs
US7659254B2
(en)
2002-02-22
2010-02-09
Shire Llc
Abuse-resistant amphetamine prodrugs
US7105486B2
(en)
2002-02-22
2006-09-12
New River Pharmaceuticals Inc.
Abuse-resistant amphetamine compounds
US7713936B2
(en)
2002-02-22
2010-05-11
Shire Llc
Abuse-resistant amphetamine prodrugs
US7662788B2
(en)
2002-02-22
2010-02-16
Shire Llc
Abuse-resistant amphetamine prodrugs
US7671031B2
(en)
2002-02-22
2010-03-02
Shire Llc
Abuse-resistant amphetamine prodrugs
US7718619B2
(en)
2002-02-22
2010-05-18
Shire Llc
Abuse-resistant amphetamine prodrugs
US7674774B2
(en)
2002-02-22
2010-03-09
Shire Llc
Abuse-resistant amphetamine prodrugs
US7678771B2
(en)
2002-02-22
2010-03-16
Shire Llc
Abuse-resistant amphetamine prodrugs
US7678770B2
(en)
2002-02-22
2010-03-16
Shire Llc
Abuse-resistant amphetamine prodrugs
US7687466B2
(en)
2002-02-22
2010-03-30
Shire Llc
Abuse-resistant amphetamine prodrugs
US7687467B2
(en)
2002-02-22
2010-03-30
Shire Llc
Abuse-resistant amphetamine prodrugs
US7700561B2
(en)
2002-02-22
2010-04-20
Shire Llc
Abuse-resistant amphetamine prodrugs
US7723305B2
(en)
2002-02-22
2010-05-25
Shire Llc
Abuse-resistant amphetamine prodrugs
US7223735B2
(en)
2003-05-29
2007-05-29
New River Pharmaceuticals Inc.
Abuse resistant lysine amphetamine compounds
US7662787B2
(en)
2003-05-29
2010-02-16
Shire Llc
Abuse resistant lysine amphetamine compounds
US8106016B2
(en)
2003-09-30
2012-01-31
Shire Llc
Compounds and compositions for prevention of overdose of oxycodone
US7375083B2
(en)
2003-09-30
2008-05-20
Shire Llc
Pharmaceutical compositions for prevention of overdose or abuse
WO2008004610A1
(en)
*
2006-07-05
2008-01-10
The University Of Tokyo
Method of treating genetic disease caused by nonsense mutation
WO2011160259A1
(en)
*
2010-06-24
2011-12-29
上海永颐生物科技有限公司
Use of n-carbamoyl glutamic acid, salts or esters thereof in manufacture of health care products for protecting liver or promoting muscle growth
CN108017561B
(en)
*
2016-11-04
2021-03-30
武汉武药科技有限公司
Method for refining carglutamic acid
CN108017561A
(en)
*
2016-11-04
2018-05-11
武汉武药科技有限公司
A kind of method of refined card glutamic acid
EP3323410A1
(en)
*
2016-11-22
2018-05-23
RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a.
Pharmaceutical parenteral formulation containing carglumic acid
KR20190086662A
(en)
*
2016-11-22
2019-07-23
레코다티인더스트리아치미카이파마슈티카에스.피.에이.
Pharmaceutical parenteral formulations containing carglum acid
WO2018095848A1
(en)
*
2016-11-22
2018-05-31
Recordati Industria Chimica E Farmaceutica S.P.A.
Pharmaceutical parenteral formulation containing carglumic acid
US11103474B2
(en)
2016-11-22
2021-08-31
Recordati Industria Chimica E Farmaceutica S.P.A.
Pharmaceutical parenteral formulation containing carglumic acid
EA039003B1
(en)
*
2016-11-22
2021-11-19
Рекордати Индустрия Кимика Э Фармасеутика С.П.А.
Pharmaceutical parenteral formulation containing carglumic acid
AU2017364135B2
(en)
*
2016-11-22
2023-06-15
Recordati Industria Chimica E Farmaceutica S.P.A.
Pharmaceutical parenteral formulation containing carglumic acid
CN112028794A
(en)
*
2019-06-03
2020-12-04
武汉武药科技有限公司
High-purity kaglutamic acid and preparation method thereof
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