GB1114970A

GB1114970A – New azepine derivatives and their production
– Google Patents

GB1114970A – New azepine derivatives and their production
– Google Patents
New azepine derivatives and their production

Info

Publication number
GB1114970A

GB1114970A
GB5740166A
GB5740166A
GB1114970A
GB 1114970 A
GB1114970 A
GB 1114970A
GB 5740166 A
GB5740166 A
GB 5740166A
GB 5740166 A
GB5740166 A
GB 5740166A
GB 1114970 A
GB1114970 A
GB 1114970A
Authority
GB
United Kingdom
Prior art keywords
formula
dibenz
azepine
dihydro
compound
Prior art date
1965-12-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB5740166A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee
JR Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1965-12-23
Filing date
1966-12-22
Publication date
1968-05-22

1966-12-22
Application filed by JR Geigy AG
filed
Critical
JR Geigy AG

1968-05-22
Publication of GB1114970A
publication
Critical
patent/GB1114970A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom

C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems

C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines

C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines

C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom

C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom

C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems

C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines

C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines

C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom

Abstract

Novel dibenzazepines of the Formula I, wherein R1 represents a C1- 4 alkyl group, each of R2 and R3 represents hydrogen or a C1- 4 alkyl group and R4 represents a C1- 4 alkyl group or, when taken together with R2, it represents an alkylene group having (3-n) or (4-n) chain members, or, together with R3, it represents an alkylene group having 4 to 6 chain members, m represents 1 or 2, n represents 0, 1 or 2 and (m + n) represents 1,2 or 3, and their acid addition salts, are prepared by (a) reacting a compound of the Formula II with an oxidizing agent, or (b) reacting a compound of the Formula III in the presence of a basic condensing agent, with a reactive ester of an amino alcohol of the Formula IV, wherein R31 represents a C1- 4 alkyl group, or (c) reacting a reactive ester of an alcohol of the Formula V with an amine of the formula HNR3R4 or (d) hydrolysing a compound of the Formula VI, wherein R5 represents a cyano group or an acyl radical of a carboxylic acid or of a monofunctional derivative of carbonic acid, and, if desired, converting a compound of Formula I obtained by any of methods (a) to (d) into an acid addition salt. 3-Methylsulphinyl- or 3-ethylsulphinyl-10,11-dihydro – 5H – dibenz[b,f]azepine is prepared by oxidizing 3-methylthio- or 3-ethylthio-5-acetyl-10,11 – dihydro – 5H – dibenz[b,f]azepine with sodium metaperiodate and hydrolysing the resulting 3 – methylsulphinyl- or 3 – ethylsulphinyl – 5 – acetyl – 10,11 – dihydro – 5H – dibenz[b,f]azepine with potassium hydroxide in ethanol. 3 – Methylsulphinyl – 5 – (3 – chloropropyl) – 10,11 – dihydro – 5H – dibenz[b,f]azepine is prepared by reacting 3-methylsulphinyl-10,11-dihydro – 5H – dibenz[b,f]azepine with 1-chloro-3-bromo-propane. Pharmaceutical compositions, having chatecholamine-potentiating and reserpine-antagonistic activity, for oral, rectal or parenteral administration, comprise a compound of Formula I together with a carrier.

GB5740166A
1965-12-23
1966-12-22
New azepine derivatives and their production

Expired

GB1114970A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

CH1774965A

CH454875A
(en)

1965-12-23
1965-12-23

Process for the production of new azepine derivatives

Publications (1)

Publication Number
Publication Date

GB1114970A
true

GB1114970A
(en)

1968-05-22

Family
ID=4427789
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB5740166A
Expired

GB1114970A
(en)

1965-12-23
1966-12-22
New azepine derivatives and their production

Country Status (13)

Country
Link

AT
(1)

AT268289B
(en)

BE
(1)

BE691640A
(en)

CH
(1)

CH454875A
(en)

DE
(1)

DE1695002A1
(en)

DK
(1)

DK122764B
(en)

ES
(1)

ES334817A1
(en)

FI
(1)

FI44236B
(en)

FR
(1)

FR1506734A
(en)

GB
(1)

GB1114970A
(en)

IL
(1)

IL27124A
(en)

NL
(1)

NL6618038A
(en)

NO
(1)

NO118920B
(en)

SE
(1)

SE333736B
(en)

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US3931151A
(en)

*

1972-10-09
1976-01-06
Roussel-Uclaf
Dibenzo (b,f) azepines

1965

1965-12-23
CH
CH1774965A
patent/CH454875A/en
unknown

1966

1966-12-16
FI
FI334866A
patent/FI44236B/fi
active

1966-12-22
NL
NL6618038A
patent/NL6618038A/xx
unknown

1966-12-22
GB
GB5740166A
patent/GB1114970A/en
not_active
Expired

1966-12-22
BE
BE691640D
patent/BE691640A/xx
unknown

1966-12-22
SE
SE1757566A
patent/SE333736B/xx
unknown

1966-12-22
DE
DE19661695002
patent/DE1695002A1/en
active
Pending

1966-12-22
DK
DK663366A
patent/DK122764B/en
unknown

1966-12-22
AT
AT1180666A
patent/AT268289B/en
active

1966-12-22
ES
ES334817A
patent/ES334817A1/en
not_active
Expired

1966-12-22
NO
NO16611866A
patent/NO118920B/no
unknown

1966-12-22
IL
IL2712466A
patent/IL27124A/en
unknown

1966-12-23
FR
FR88632A
patent/FR1506734A/en
not_active
Expired

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US3931151A
(en)

*

1972-10-09
1976-01-06
Roussel-Uclaf
Dibenzo (b,f) azepines

Also Published As

Publication number
Publication date

CH454875A
(en)

1968-04-30

NO118920B
(en)

1970-03-02

FI44236B
(en)

1971-06-30

ES334817A1
(en)

1968-03-01

DE1695002A1
(en)

1971-03-25

NL6618038A
(en)

1967-06-26

AT268289B
(en)

1969-02-10

IL27124A
(en)

1970-10-30

SE333736B
(en)

1971-03-29

FR1506734A
(en)

1967-12-22

BE691640A
(en)

1967-06-22

DK122764B
(en)

1972-04-10

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