GB1133107A

GB1133107A – Improvements in or relating to steroids and the manufacture thereof
– Google Patents

GB1133107A – Improvements in or relating to steroids and the manufacture thereof
– Google Patents
Improvements in or relating to steroids and the manufacture thereof

Info

Publication number
GB1133107A

GB1133107A
GB12855/66A
GB1285566A
GB1133107A
GB 1133107 A
GB1133107 A
GB 1133107A
GB 12855/66 A
GB12855/66 A
GB 12855/66A
GB 1285566 A
GB1285566 A
GB 1285566A
GB 1133107 A
GB1133107 A
GB 1133107A
Authority
GB
United Kingdom
Prior art keywords
hydrogen
compound
formula
defined above
treating
Prior art date
1965-03-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB12855/66A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pharmacia and Upjohn Co

Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1965-03-24
Filing date
1966-03-23
Publication date
1968-11-06

1966-03-23
Application filed by Upjohn Co
filed
Critical
Upjohn Co

1968-11-06
Publication of GB1133107A
publication
Critical
patent/GB1133107A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07J—STEROIDS

C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07J—STEROIDS

C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07J—STEROIDS

C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07J—STEROIDS

C07J75/00—Processes for the preparation of steroids in general

Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC

Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y10S435/00—Chemistry: molecular biology and microbiology

Y10S435/8215—Microorganisms

Y10S435/911—Microorganisms using fungi

Abstract

1,133,107. Steroids. UPJOHN CO. 23 March, 1966 [24 March, 1965], No. 12855/66. Heading C2U. [Also in Division A5] Novel compounds having the formulµ wherein R is hydrogen or the acyl radical of a hydrocarbon carboxylic acid of 1-16 carbon atoms inclusive; R 1 is hydrogen or methyl; R 2 is hydrogen, methyl, fluorine, chlorine or methoxy; X is Y is hydrogen or fluorine; -C 1 -C 2 – is a divalent radical selected from -CH 2 -CH 2 – and -CH = CH- and wherein when Y is Y is limited to hydrogen, R 4 is hydrogen or an alkyl radical of 1-8 carbon atoms, are obtained by treating a compound of the formula wherein R 1 , R 2 , R 4 and Y are as defined above and X 1 is with an organic sulphonic halide, treating the 6α-(21-orgaric sulphonyloxyethyl) derivative so obtained to treatment with a strong base to produce the corresponding 6,11-spirocyclopropyl compound, if desired when X1 is oxidizing to produce the corresponding 11-keto derivative, and/or hydrolysing with an aqueous organic acid to obtain a 17α,21-dihydroxypregn-20-one, which if desired may be acylated in 21-position, and if desired, dehydrogenating in 1,2-position. The 2-hydroxy methylene compounds are obtained from the corresponding compounds wherein R1 is hydrogen by treatment with an alkyl formate and sodium hydride. The starting compounds may be obtained (a) by treating a compound of the formula wherein R 1 , R 2 , X and R 4 are as defined above and -(N is a cyclic amino group with a reducing agent followed by hydrolysis, (b) by dehydrating a compound of the formula wherein R 1 , R 2 , R 4 , X and Y are as defined above and (c) by hydrolysing a compound of the formula wherein R 1 , R 2 , R 4 , X 1 and Y are as defined above and is an alkylenedioxy radical.

GB12855/66A
1965-03-24
1966-03-23
Improvements in or relating to steroids and the manufacture thereof

Expired

GB1133107A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

US44252065A

1965-03-24
1965-03-24

Publications (1)

Publication Number
Publication Date

GB1133107A
true

GB1133107A
(en)

1968-11-06

Family
ID=23757118
Family Applications (2)

Application Number
Title
Priority Date
Filing Date

GB12855/66A
Expired

GB1133107A
(en)

1965-03-24
1966-03-23
Improvements in or relating to steroids and the manufacture thereof

GB26179/68A
Expired

GB1133108A
(en)

1965-03-24
1966-03-23
Improvements in or relating to steroids and the manufacture thereof

Family Applications After (1)

Application Number
Title
Priority Date
Filing Date

GB26179/68A
Expired

GB1133108A
(en)

1965-03-24
1966-03-23
Improvements in or relating to steroids and the manufacture thereof

Country Status (6)

Country
Link

US
(1)

US3475417A
(en)

CH
(1)

CH530385A
(en)

DE
(1)

DE1593612A1
(en)

GB
(2)

GB1133107A
(en)

IL
(1)

IL25300A
(en)

NL
(1)

NL6603853A
(en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US3932388A
(en)

*

1974-04-22
1976-01-13
Schering Corporation
-Azido-4,6-pregnadieno(3,2-c)pyrazoles, processes for their preparation and intermediates useful therein

Family Cites Families (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US3412154A
(en)

*

1964-08-12
1968-11-19
Parke Davis & Co
Amino-substituted phenone compounds

1965

1965-03-24
US
US442520A
patent/US3475417A/en
not_active
Expired – Lifetime

1966

1966-03-03
IL
IL25300A
patent/IL25300A/en
unknown

1966-03-09
CH
CH332666A
patent/CH530385A/en
not_active
IP Right Cessation

1966-03-19
DE
DE19661593612
patent/DE1593612A1/en
active
Pending

1966-03-23
GB
GB12855/66A
patent/GB1133107A/en
not_active
Expired

1966-03-23
GB
GB26179/68A
patent/GB1133108A/en
not_active
Expired

1966-03-24
NL
NL6603853A
patent/NL6603853A/xx
unknown

Also Published As

Publication number
Publication date

NL6603853A
(en)

1966-09-26

DE1593612A1
(en)

1970-08-06

GB1133108A
(en)

1968-11-06

US3475417A
(en)

1969-10-28

CH530385A
(en)

1972-11-15

IL25300A
(en)

1970-03-22

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