GB1153130A – Anti-Diabetically Effective Sulphonyl-Ureas and Sulphonyl-Semicarbazides
– Google Patents
GB1153130A – Anti-Diabetically Effective Sulphonyl-Ureas and Sulphonyl-Semicarbazides
– Google Patents
Anti-Diabetically Effective Sulphonyl-Ureas and Sulphonyl-Semicarbazides
Info
Publication number
GB1153130A
GB1153130A
GB12220/68A
GB1222068A
GB1153130A
GB 1153130 A
GB1153130 A
GB 1153130A
GB 12220/68 A
GB12220/68 A
GB 12220/68A
GB 1222068 A
GB1222068 A
GB 1222068A
GB 1153130 A
GB1153130 A
GB 1153130A
Authority
GB
United Kingdom
Prior art keywords
radical
sulphonamide
compounds
formula
carbons
Prior art date
1967-03-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB12220/68A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1967-03-15
Filing date
1968-03-13
Publication date
1969-05-21
1968-03-13
Application filed by Boehringer Mannheim GmbH
filed
Critical
Boehringer Mannheim GmbH
1969-05-21
Publication of GB1153130A
publication
Critical
patent/GB1153130A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
C07D295/28—Nitrogen atoms
C07D295/32—Nitrogen atoms acylated with carboxylic or carbonic acids, or their nitrogen or sulfur analogues
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
C07D209/56—Ring systems containing three or more rings
C07D209/80—[b, c]- or [b, d]-condensed
C07D209/82—Carbazoles; Hydrogenated carbazoles
C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
C07D311/78—Ring systems having three or more relevant rings
C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
C07D311/82—Xanthenes
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
C07D313/02—Seven-membered rings
C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
C07D313/12—[b,e]-condensed
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
C07D337/02—Seven-membered rings
C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
C07D337/12—[b,e]-condensed
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
C07D337/16—Eight-membered rings
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C2603/00—Systems containing at least three condensed rings
C07C2603/02—Ortho- or ortho- and peri-condensed systems
C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
C07C2603/18—Fluorenes; Hydrogenated fluorenes
Abstract
1,153,130. Sulphonamide derivatives. BOEHRINGER MANNHEIM G.m.b.H. 13 March, 1968 [15 March, 1967], No. 12220/68. Heading C2C. Novel anti-diabetically effective compounds of the general formula wherein X is -O- -S-, -O-CH 2 – – S-CH 2 -, -S-CH 2 -CH 2 -, -NH.CH 2 – which may be alkylated or acylated), -NH.CO- (which may be alkylated), a, saturated or unsaturated, straight- or branchedchain alkylene radical containing up to 3 carbons, or a valency bond; R 1 is H, CF 3 , halogen, alkyl or alkoxy; Y is a saturated or unsaturated straight- or branched-chain alkylene radical containing up to 6 carbons which may also contain an oxygen or nitrogen atom; Z is a straight- or branched-chain alkylene radical containing up to 4 carbons; and R 2 is a straight- or branched-chain, saturated or unsaturated aliphatic hydrocarbon radical or a cycloalkyl radical (may be substituted, e.g. by Me or MeO) which can also be interrupted by oxygen or sulphur atoms or can contain an endo-alkylene radical, or is an unsubstituted or substituted aryl or aralkyl radical or an unsubstituted or substituted, saturated or unsaturated alkylene-imino radical containing 3 to 7 carbons which can also contain an endoalkylene radical, are prepared: (a) by reacting the appropriate sulphonamide or sulphonylisocyanate with compounds of the formula R 2 NCO or R 2 .NH 2 respectively; acylamino derivatives may also be utilized; (b) by hydrolysing compounds of the general formulµ Q.NH.Z.C 6 H 4 .SO 2 NH.C: SNHR 2 , Q.NHZ.C 6 H 4 .SO 2 .NH.C(: NH)NHR 2 or QNHZ.C 6 H 4 .SO 2 NH.C(: NR 2 )-A-Alkyl (A is oxygen or sulphur and Q is the tricyclic radical shown in the formula illustrated above with a -CO- group attached to Y); (c) by acylating, using, for example Q.COCl, compounds of the formula NH 2 .Z.C 6 H 4 .SO 2 .NH.CO.NH.R 2 ; or (d) by reacting a corresponding benzenesulphonyl halide with a compound of the formula H 2 N.CONHR 2 or parabanic acid derivative thereof; in the latter case a final hydrolysis step is necessary. Acylaminoethyl – benzene – sulphonamides corresponding to the above novel compounds are obtained by the interaction of QCOCI and 4 – (#- aminoethyl) – benzene – sulphonamide (prepared by the chlorosulphonation of N-acetyl-#- phenyl-ethylamine, followed by amination of the sulphochloride obtained to give 4-(#-N- acetylaminoethyl) – benzene – sulphonamide and subsequent deacetylation) in the presence of sodium carbonate; the sodium salt precipitates out which is converted to the sulphonamide. Treatment of the sulphonamides with pyrocarbonic acid diethyl ester in the presence of dimethyl formamide and sodium hydride followed by acidification affords the corresponding arylaminoethyl – benzenesulphonylcarbamic acid esters, e.g. the ethyl esters.
GB12220/68A
1967-03-15
1968-03-13
Anti-Diabetically Effective Sulphonyl-Ureas and Sulphonyl-Semicarbazides
Expired
GB1153130A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
DEB0091627
1967-03-15
Publications (1)
Publication Number
Publication Date
GB1153130A
true
GB1153130A
(en)
1969-05-21
Family
ID=6985951
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB12220/68A
Expired
GB1153130A
(en)
1967-03-15
1968-03-13
Anti-Diabetically Effective Sulphonyl-Ureas and Sulphonyl-Semicarbazides
Country Status (6)
Country
Link
US
(2)
US3646009A
(en)
AT
(4)
AT281052B
(en)
CH
(1)
CH516535A
(en)
FR
(1)
FR1556173A
(en)
GB
(1)
GB1153130A
(en)
NL
(1)
NL6803656A
(en)
Families Citing this family (7)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
DE2413514C3
(en)
*
1974-03-21
1982-03-04
Hoechst Ag, 6000 Frankfurt
N-Acylaminoathylbenzenesulfonyl-N’-methylureas, process for their preparation and their use
GB1472382A
(en)
*
1975-01-16
1977-05-04
Wyeth John & Brother Ltd
Dibenzopyrimidoazepines
DE2629752A1
(en)
*
1976-07-02
1978-01-05
Boehringer Mannheim Gmbh
NEW CARBONIC ACID DERIVATIVES AND THE PROCESS FOR THEIR PRODUCTION
DE2951135A1
(en)
*
1979-12-19
1981-06-25
Hoechst Ag, 6230 Frankfurt
SULFONYL UREAS, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS BASED ON THESE COMPOUNDS AND THEIR USE
EP0031088A1
(en)
*
1979-12-19
1981-07-01
Hoechst Aktiengesellschaft
Benzene-sulfonyl ureas, processes for their preparation, pharmaceutical compositions based on these compounds and their use
JPS56166180A
(en)
1980-05-28
1981-12-21
Chugai Pharmaceut Co Ltd
Dibenzoxazepine derivative and its preparation
US4518776A
(en)
*
1982-07-19
1985-05-21
Ciba Geigy Corporation
Process for producing sulfonylureas
1968
1968-03-11
US
US711840A
patent/US3646009A/en
not_active
Expired – Lifetime
1968-03-13
CH
CH367568A
patent/CH516535A/en
not_active
IP Right Cessation
1968-03-13
GB
GB12220/68A
patent/GB1153130A/en
not_active
Expired
1968-03-14
AT
AT254568A
patent/AT281052B/en
not_active
IP Right Cessation
1968-03-14
AT
AT584469A
patent/AT281062B/en
not_active
IP Right Cessation
1968-03-14
AT
AT584369A
patent/AT281061B/en
not_active
IP Right Cessation
1968-03-14
AT
AT05845/69A
patent/AT281063B/en
not_active
IP Right Cessation
1968-03-14
NL
NL6803656A
patent/NL6803656A/xx
unknown
1968-03-15
FR
FR1556173D
patent/FR1556173A/fr
not_active
Expired
1971
1971-09-21
US
US00182516A
patent/US3752851A/en
not_active
Expired – Lifetime
Also Published As
Publication number
Publication date
NL6803656A
(en)
1968-09-16
DE1618112A1
(en)
1972-05-10
US3752851A
(en)
1973-08-14
AT281062B
(en)
1970-05-11
CH516535A
(en)
1971-12-15
AT281061B
(en)
1970-05-11
FR1556173A
(en)
1969-01-31
DE1618112B2
(en)
1975-06-12
AT281052B
(en)
1970-05-11
US3646009A
(en)
1972-02-29
AT281063B
(en)
1970-05-25
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Legal Events
Date
Code
Title
Description
1969-10-15
PS
Patent sealed [section 19, patents act 1949]
1978-10-18
PCNP
Patent ceased through non-payment of renewal fee
