GB1160933A – Improvements in or relating to New Derivatives of 5-Cycloalkanespiro Oxazolidines
– Google Patents
GB1160933A – Improvements in or relating to New Derivatives of 5-Cycloalkanespiro Oxazolidines
– Google Patents
Improvements in or relating to New Derivatives of 5-Cycloalkanespiro Oxazolidines
Info
Publication number
GB1160933A
GB1160933A
GB27238/67A
GB2723867A
GB1160933A
GB 1160933 A
GB1160933 A
GB 1160933A
GB 27238/67 A
GB27238/67 A
GB 27238/67A
GB 2723867 A
GB2723867 A
GB 2723867A
GB 1160933 A
GB1160933 A
GB 1160933A
Authority
GB
United Kingdom
Prior art keywords
radical
formula
cycloalkanespiro
straight
branched chain
Prior art date
1967-06-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB27238/67A
Inventor
Jacques Georges Maillard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Jacques Logeais SA
Original Assignee
Laboratoires Jacques Logeais SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1967-06-13
Filing date
1967-06-13
Publication date
1969-08-06
1967-06-13
Application filed by Laboratoires Jacques Logeais SA
filed
Critical
Laboratoires Jacques Logeais SA
1967-06-13
Priority to GB27238/67A
priority
Critical
patent/GB1160933A/en
1967-06-13
Priority to FR110072M
priority
patent/FR6720M/fr
1968-05-10
Priority to US728330A
priority
patent/US3528982A/en
1968-05-29
Priority to BE715840D
priority
patent/BE715840A/xx
1968-06-05
Priority to US734522A
priority
patent/US3565905A/en
1968-06-10
Priority to CH856568A
priority
patent/CH492728A/en
1968-06-11
Priority to FR7456D
priority
patent/FR7456M/fr
1968-06-12
Priority to DE19681770621
priority
patent/DE1770621A1/en
1969-08-06
Publication of GB1160933A
publication
Critical
patent/GB1160933A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
Abstract
1,160,933. 5 – Cycloalkanespiro oxazolidine derivatives. LABORATOIRES JACQUES LOGEAIS. 31 May, 1968 [13 June, 1967], No. 27238/67. Heading C2C. Novel 5-cycloalkanespiro oxazolidines having the general formula (I):- wherein n is an integer equal to 4, 5 or 6; R 1 is a straight or branched chain alkyl radical, a cycloalkyl radical, an aryl radical (optionally substituted with one or two halogen, hydroxy, alkyl, alkoxy, nitro, amino, alkylamino or -O-CH 2 -O groups), an aralkyl radical (optionally nuclearly substituted with one of the aforesaid substituents), a furyl, thienyl or pyridyl radical; R 2 is a straight or branched chain alkyl radical, or an aralkyl radical (optionally nuclearly substituted with one of the aforesaid substituents); R 3 is a straight or branched chain alkyl radical, an aryl radical (optionally substituted by a halogen, alkyl, alkoxy, or -N(CH 3 ) 2 group), or R 3 , together with R 2 , the carbon atom carrying R 3 and N forms a saturated ring having 4 or 5 carbon atoms; R 4 is hydrogen or a lower alkyl group having 1 to 6 carbon atoms; or their acid addition salts are prepared by reacting an aldehyde of the formula R 1 -CHO with an amine of the Formula (II): The reaction is preferably carried out under reflux in an anhydrous solvent such as benzene or toluene, the water formed being removed by means of a dehydrating agent such as driesite or p-toluene sulphonic acid. On completion of the reaction, the desired product may be separated from the reaction medium by evaporating the solvent under reduced pressure. The product may be purified with ether. Pharmaceutical compositions having coronary vasodilating properties which are of particular value therapeutically for the treatment of myocardial infarction and of angina pectoris and containing a compound defined above having the Formula (I) or their acid addition salts are administered parenterally or orally in association with a pharmaceutically administrable vehicle or excipient.
GB27238/67A
1967-06-13
1967-06-13
Improvements in or relating to New Derivatives of 5-Cycloalkanespiro Oxazolidines
Expired
GB1160933A
(en)
Priority Applications (8)
Application Number
Priority Date
Filing Date
Title
GB27238/67A
GB1160933A
(en)
1967-06-13
1967-06-13
Improvements in or relating to New Derivatives of 5-Cycloalkanespiro Oxazolidines
FR110072M
FR6720M
(en)
1967-06-13
1967-06-13
US728330A
US3528982A
(en)
1967-06-13
1968-05-10
N-dialkylaminoalkyl-3,4-dihydro-2(1h)-quinazolinones
BE715840D
BE715840A
(en)
1967-06-13
1968-05-29
US734522A
US3565905A
(en)
1967-06-13
1968-06-05
Derivatives of 5-cycloalkanespiro oxazolidines
CH856568A
CH492728A
(en)
1967-06-13
1968-06-10
Process for the preparation of derivatives of cycloalkanespiro-5 oxazolidines
FR7456D
FR7456M
(en)
1967-06-13
1968-06-11
DE19681770621
DE1770621A1
(en)
1967-06-13
1968-06-12
New derivatives of 5-cycloalkane spirooxazolidines and processes for their preparation
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
GB27238/67A
GB1160933A
(en)
1967-06-13
1967-06-13
Improvements in or relating to New Derivatives of 5-Cycloalkanespiro Oxazolidines
Publications (1)
Publication Number
Publication Date
GB1160933A
true
GB1160933A
(en)
1969-08-06
Family
ID=10256350
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB27238/67A
Expired
GB1160933A
(en)
1967-06-13
1967-06-13
Improvements in or relating to New Derivatives of 5-Cycloalkanespiro Oxazolidines
Country Status (5)
Country
Link
US
(1)
US3565905A
(en)
BE
(1)
BE715840A
(en)
DE
(1)
DE1770621A1
(en)
FR
(1)
FR7456M
(en)
GB
(1)
GB1160933A
(en)
Families Citing this family (2)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US3931212A
(en)
*
1973-07-19
1976-01-06
Warner-Lambert Company
Method for treating cardiovascular circulatory insufficiencies and hypotonia with 2-hydroxy-phenyl-1-oxa-4-azaspiroalkane derivatives
DE2804824A1
(en)
*
1978-02-04
1979-08-09
Bayer Ag
SPIRO DERIVATIVES OF 3- (3,5-DIHALOGENPHENYL) -OXAZOLIDIN-2,4-DIONES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS FUNGICIDES
1967
1967-06-13
GB
GB27238/67A
patent/GB1160933A/en
not_active
Expired
1968
1968-05-29
BE
BE715840D
patent/BE715840A/xx
unknown
1968-06-05
US
US734522A
patent/US3565905A/en
not_active
Expired – Lifetime
1968-06-11
FR
FR7456D
patent/FR7456M/fr
not_active
Expired
1968-06-12
DE
DE19681770621
patent/DE1770621A1/en
active
Pending
Also Published As
Publication number
Publication date
DE1770621A1
(en)
1972-03-09
US3565905A
(en)
1971-02-23
FR7456M
(en)
1969-11-24
BE715840A
(en)
1968-10-16
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Legal Events
Date
Code
Title
Description
1969-12-17
PS
Patent sealed [section 19, patents act 1949]
1972-06-07
435
Patent endorsed ‘licences of right’ on the date specified (sect. 35/1949)
1976-12-31
PLNP
Patent lapsed through nonpayment of renewal fees
