GB1294733A – 4-aryl-4-hydroxypiperidine derivatives and processes for the preparation thereof
– Google Patents
GB1294733A – 4-aryl-4-hydroxypiperidine derivatives and processes for the preparation thereof
– Google Patents
4-aryl-4-hydroxypiperidine derivatives and processes for the preparation thereof
Info
Publication number
GB1294733A
GB1294733A
GB39975/70A
GB3997570A
GB1294733A
GB 1294733 A
GB1294733 A
GB 1294733A
GB 39975/70 A
GB39975/70 A
GB 39975/70A
GB 3997570 A
GB3997570 A
GB 3997570A
GB 1294733 A
GB1294733 A
GB 1294733A
Authority
GB
United Kingdom
Prior art keywords
phenyl
general formula
methyl
oxo
prepared
Prior art date
1969-09-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB39975/70A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1969-09-03
Filing date
1970-08-19
Publication date
1972-11-01
1970-08-19
Application filed by Janssen Pharmaceutica NV
filed
Critical
Janssen Pharmaceutica NV
1972-11-01
Publication of GB1294733A
publication
Critical
patent/GB1294733A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C17/00—Preparation of halogenated hydrocarbons
C07C17/35—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction
C07C17/354—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction by hydrogenation
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
C07C271/06—Esters of carbamic acids
C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
C07D211/02—Preparation by ring-closure or hydrogenation
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C07D211/40—Oxygen atoms
C07D211/44—Oxygen atoms attached in position 4
C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
C07D211/74—Oxygen atoms
Abstract
1294733 4 – Phenyl – 1 – (4,4 – diphenylbutyl)- 4-hydroxy-piperidines JANSSEN PHARMACEUTICA NV 19 Aug 1970 [3 Sept 1969] 39975/70 Heading C2C Novel 4 – phenyl – 1 – (4,4 – diphenylbutyl). 4-hydroxy-piperidines of the general formula wherein R is a hydrogen atom or a methyl group, Ar 1 is a halophenyl group, Ar 2 is a phenyl or halophenyl group and Ar 3 is a phenyl, C 1-5 alkyl-phenyl, trifluoromethyl-phenyl, halophenyl, dihalophehyl, C 1-5 alkyl-halophenyl or trifluoromethyl-halophenyl group, and therapeutically acceptable acid addition salts thereof are prepared by heating a reactive ester of a 4,4- diphenyl-butan-1-ol of the general formula Ar 1 Ar 2 CH(CH 2 ) 3 OH with a 4-phenyl-4-hydroxypiperidine of the general formula followed optionally by salification of the product. 4-Phenyl-4-hydroxypiperidines of the third general formula above are prepared by condensing a 1-alkoxycarbonyl-4-oxo-piperidine of the general formula with a phenyl magnesium bromide of the general formula BrMgAr 3 under Grignard conditions and heating the resulting 1-alkoxycarbonyl-4-phenyl-4-hydroxypiperidine of the general formula with an alkali. Methyl 3-methyl-4-oxo-1-piperidine-carboxylate is prepared by reacting dimethyl 3,3
GB39975/70A
1969-09-03
1970-08-19
4-aryl-4-hydroxypiperidine derivatives and processes for the preparation thereof
Expired
GB1294733A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
US85501669A
1969-09-03
1969-09-03
Publications (1)
Publication Number
Publication Date
GB1294733A
true
GB1294733A
(en)
1972-11-01
Family
ID=25320131
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB39975/70A
Expired
GB1294733A
(en)
1969-09-03
1970-08-19
4-aryl-4-hydroxypiperidine derivatives and processes for the preparation thereof
Country Status (22)
Country
Link
US
(1)
US3575990A
(en)
JP
(1)
JPS4932543B1
(en)
AT
(1)
AT299201B
(en)
BE
(1)
BE755589A
(en)
BR
(1)
BR6915392D0
(en)
CH
(1)
CH520671A
(en)
CS
(1)
CS159779B2
(en)
DE
(1)
DE2040231C3
(en)
DK
(1)
DK127424B
(en)
ES
(1)
ES383006A1
(en)
FI
(1)
FI51176C
(en)
FR
(1)
FR2068536B1
(en)
GB
(1)
GB1294733A
(en)
IL
(1)
IL35211A
(en)
IT
(1)
IT1040516B
(en)
NL
(1)
NL172446C
(en)
NO
(1)
NO131173C
(en)
PL
(1)
PL71070B1
(en)
RO
(1)
RO57021A
(en)
SE
(1)
SE354066B
(en)
YU
(1)
YU34354B
(en)
ZA
(1)
ZA706024B
(en)
Families Citing this family (6)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US4039676A
(en)
*
1975-06-23
1977-08-02
Ciba-Geigy Corporation
2-piperidinoalkyl-1,4-benzodioxans
US4129655A
(en)
*
1976-04-26
1978-12-12
Ciba-Geigy Corporation
Neuroleptic 2-piperidinoalkyl-1,4-benzodioxans
US4383999A
(en)
*
1981-05-26
1983-05-17
Smithkline Beckman Corporation
Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters
US4514414A
(en)
*
1982-10-25
1985-04-30
Smithkline Beckman Corporation
N-Substituted pyrrolidineacetic acids and their esters
IL90858A
(en)
*
1988-07-07
1994-08-26
Rhone Poulenc Sante
Derivatives of (AZA) naphthalensultam, their preparation and compositions containing them
DE102004036349A1
(en)
*
2004-07-27
2006-03-23
Grünenthal GmbH
Substituted 3-phenylpiperidine derivatives
Family Cites Families (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
GB931788A
(en)
*
1960-01-14
1963-07-17
Sandoz Ltd
Improvements in or relating to benzhydryl esters
0
BE
BE755589D
patent/BE755589A/en
not_active
IP Right Cessation
1969
1969-09-03
US
US855016A
patent/US3575990A/en
not_active
Expired – Lifetime
1969-12-19
BR
BR215392/69A
patent/BR6915392D0/en
unknown
1970
1970-08-13
DE
DE2040231A
patent/DE2040231C3/en
not_active
Expired
1970-08-18
NL
NLAANVRAGE7012199,A
patent/NL172446C/en
not_active
IP Right Cessation
1970-08-19
GB
GB39975/70A
patent/GB1294733A/en
not_active
Expired
1970-08-24
CS
CS5805A
patent/CS159779B2/cs
unknown
1970-08-24
ES
ES383006A
patent/ES383006A1/en
not_active
Expired
1970-08-27
FR
FR707031281A
patent/FR2068536B1/fr
not_active
Expired
1970-08-28
CH
CH1293670A
patent/CH520671A/en
not_active
IP Right Cessation
1970-08-31
AT
AT788670A
patent/AT299201B/en
not_active
IP Right Cessation
1970-09-01
YU
YU2188/70A
patent/YU34354B/en
unknown
1970-09-01
IT
IT53154/70A
patent/IT1040516B/en
active
1970-09-02
IL
IL35211A
patent/IL35211A/en
unknown
1970-09-02
NO
NO3360/70A
patent/NO131173C/no
unknown
1970-09-02
ZA
ZA706024A
patent/ZA706024B/en
unknown
1970-09-02
FI
FI702426A
patent/FI51176C/en
active
1970-09-02
SE
SE11923/70A
patent/SE354066B/xx
unknown
1970-09-02
RO
RO64358A
patent/RO57021A/ro
unknown
1970-09-02
PL
PL1970142947A
patent/PL71070B1/pl
unknown
1970-09-03
JP
JP45077475A
patent/JPS4932543B1/ja
active
Pending
1970-09-03
DK
DK452570AA
patent/DK127424B/en
not_active
IP Right Cessation
Also Published As
Publication number
Publication date
RO57021A
(en)
1974-12-11
NL7012199A
(en)
1971-03-05
AT299201B
(en)
1972-06-12
NO131173B
(en)
1975-01-06
FI51176C
(en)
1976-11-10
FI51176B
(en)
1976-08-02
NO131173C
(en)
1975-04-16
US3575990A
(en)
1971-04-20
YU218870A
(en)
1978-12-31
JPS4932543B1
(en)
1974-08-31
DE2040231C3
(en)
1979-04-12
FR2068536A1
(en)
1971-08-27
SE354066B
(en)
1973-02-26
ES383006A1
(en)
1973-07-01
DE2040231A1
(en)
1971-03-18
CS159779B2
(en)
1975-01-31
BE755589A
(en)
1971-03-02
IT1040516B
(en)
1979-12-20
NL172446C
(en)
1983-09-01
YU34354B
(en)
1979-07-10
DK127424B
(en)
1973-11-05
ZA706024B
(en)
1972-04-26
IL35211A0
(en)
1970-11-30
DE2040231B2
(en)
1978-08-10
FR2068536B1
(en)
1973-07-13
CH520671A
(en)
1972-03-31
IL35211A
(en)
1973-11-28
PL71070B1
(en)
1974-04-30
BR6915392D0
(en)
1973-01-16
NL172446B
(en)
1983-04-05
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Legal Events
Date
Code
Title
Description
1973-03-14
PS
Patent sealed [section 19, patents act 1949]
1990-09-19
PE20
Patent expired after termination of 20 years
