GB1301366A

GB1301366A – – Google Patents

GB1301366A – – Google Patents

Info

Publication number
GB1301366A

GB1301366A

GB1301366DA
GB1301366A
GB 1301366 A
GB1301366 A
GB 1301366A

GB 1301366D A
GB1301366D A
GB 1301366DA
GB 1301366 A
GB1301366 A
GB 1301366A
Authority
GB
United Kingdom
Prior art keywords
compound
alkyl
reacting
prepared
compounds
Prior art date
1969-08-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1969-08-07
Filing date
1970-08-07
Publication date
1972-12-29

1970-08-07
Application filed
filed
Critical

1972-12-29
Publication of GB1301366A
publication
Critical
patent/GB1301366A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom

C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems

C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines

C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines

Abstract

1301366 Dibenzazepine derivatives RHONEPOULENC SA 7 Aug 1970 [7 Aug 1969] 38279/70 Heading C2C Novel compounds I: (in which each of R and R1 is H, C 1-5 alkyl, C 1-5 hydroxyalkyl, hydroxyalkoxyalkyl of 1-5 carbon atoms in each alkyl residue, or phenyl-C 1-5 alkyl optionally substituted in the phenyl nucleus by one or more of halogen, C 1-5 alkyl, C 1-5 alkoxy, NH 2 or CF 3 , R 1 is H or C 1-5 alkyl and one of the symbols X is Cl and the other symbols X are each H) and acid addition salts and quaternary ammonium derivatives thereof, are prepared by (a) reducing a compound II: or (b) reducing a compound III: (in which CH 2 R 2 has the same meaning as R1 and R3 is H, C 1-5 alkyl or phenyl-C 1-5 alkyl optionally substituted by one or more of halogen, C 1-5 alkyl, C 1-5 alkoxy or CF 3 ), or (c) reacting a compound IV: with a compound of formula R 2 CHO, or (d) reacting a compound V: (in which Ac is acyl) with a compound of formula R 2 CHO, and removing the acyl group in the resulting product by hydrolysis, or (e) reacting a compound IV with a compound of formula R 4 -Z (in which R 4 has the same meaning as R1 but is not H, and Z is a reactive ester residue) or (f) replacing the radical Y in a compound VI: (in which Y is CN, alkoxycarbonyl, alkanoyl alkanesulphonyl or arylsulphonyl) by a hydrogen atom, or (g) reducing a compound VII: (in which R 5 is H or C 1-5 alkyl and R 6 is C 1-5 alkyl), and, if desired, converting a resulting compound into an acid addition salt or quaternary ammonium derivative. Compounds II are prepared by reacting a compound C: with hydroxylamine. Compounds X and intermediates therefor are prepared by the following reacting schemes A and B: Compounds III are prepared by acylation of com unds VIII: 2 – Chloro – 5 – methyl – 10 – ethoxycarbonylamino – 10,11 – dihydro – dibenzo[b,f]azepine is prepared by reacting ethyl chloroformate with 2 – chloro – 5 – methyl – 10 – amino – 10,11 – dihydrodibenzo[b,f]azepine. Pharmaceutical compositions for oral, rectal, parenteral or topical administration, comprise a compound I or a non-toxic acid addition salt or quaternary ammonium derivative thereof, together with a pharmaceutical carrier. The active ingredients have antidepressant, analgesic, anticonvulsive and tranquillizing activity.

GB1301366D
1969-08-07
1970-08-07

Expired

GB1301366A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

FR6927226A

FR2069831A1
(en)

1969-08-07
1969-08-07

Publications (1)

Publication Number
Publication Date

GB1301366A
true

GB1301366A
(en)

1972-12-29

Family
ID=9038789
Family Applications (2)

Application Number
Title
Priority Date
Filing Date

GB1301367D
Expired

GB1301367A
(en)

1969-08-07
1970-08-07

GB1301366D
Expired

GB1301366A
(en)

1969-08-07
1970-08-07

Family Applications Before (1)

Application Number
Title
Priority Date
Filing Date

GB1301367D
Expired

GB1301367A
(en)

1969-08-07
1970-08-07

Country Status (17)

Country
Link

JP
(1)

JPS4939275B1
(en)

AT
(2)

AT301556B
(en)

BE
(1)

BE754532A
(en)

CH
(1)

CH516560A
(en)

CS
(2)

CS163772B2
(en)

DE
(2)

DE2064879A1
(en)

ES
(2)

ES382564A1
(en)

FR
(1)

FR2069831A1
(en)

GB
(2)

GB1301367A
(en)

IE
(1)

IE34441B1
(en)

IL
(1)

IL35070A0
(en)

LU
(1)

LU61484A1
(en)

NL
(1)

NL7011296A
(en)

OA
(1)

OA03651A
(en)

PL
(1)

PL82685B1
(en)

SU
(2)

SU370777A3
(en)

ZA
(1)

ZA705448B
(en)

Cited By (2)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

GB2305177A
(en)

*

1995-09-16
1997-04-02
Agrevo Uk Ltd
Fungicidal amides

EP1765768B1
(en)

*

2004-07-08
2013-11-06
AstraZeneca AB
Substituted acids for the treatment of respiratory diseases

Families Citing this family (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

FR2198942B1
(en)

*

1972-09-12
1975-03-14
Rhone Poulenc Ind

0

BE
BE754532D
patent/BE754532A/en
unknown

1969

1969-08-07
FR
FR6927226A
patent/FR2069831A1/fr
not_active
Withdrawn

1970

1970-07-29
OA
OA53994A
patent/OA03651A/en
unknown

1970-07-30
NL
NL7011296A
patent/NL7011296A/xx
unknown

1970-08-03
SU
SU1466527A
patent/SU370777A3/ru
active

1970-08-03
SU
SU1663229A
patent/SU399124A3/ru
active

1970-08-04
CS
CS7446*A
patent/CS163772B2/cs
unknown

1970-08-04
CS
CS5442A
patent/CS163771B2/cs
unknown

1970-08-06
ZA
ZA705448A
patent/ZA705448B/en
unknown

1970-08-06
LU
LU61484D
patent/LU61484A1/xx
unknown

1970-08-06
IL
IL35070A
patent/IL35070A0/en
unknown

1970-08-06
CH
CH1186870A
patent/CH516560A/en
not_active
IP Right Cessation

1970-08-06
PL
PL1970142553A
patent/PL82685B1/en
unknown

1970-08-06
IE
IE1014/70A
patent/IE34441B1/en
unknown

1970-08-07
ES
ES382564A
patent/ES382564A1/en
not_active
Expired

1970-08-07
AT
AT581571A
patent/AT301556B/en
not_active
IP Right Cessation

1970-08-07
DE
DE19702064879
patent/DE2064879A1/de
active
Pending

1970-08-07
GB
GB1301367D
patent/GB1301367A/en
not_active
Expired

1970-08-07
DE
DE19702039396
patent/DE2039396A1/en
active
Pending

1970-08-07
GB
GB1301366D
patent/GB1301366A/en
not_active
Expired

1970-08-07
AT
AT721170A
patent/AT299211B/en
not_active
IP Right Cessation

1970-09-04
ES
ES383390A
patent/ES383390A1/en
not_active
Expired

1971

1971-04-13
JP
JP46022821A
patent/JPS4939275B1/ja
active
Pending

Cited By (2)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

GB2305177A
(en)

*

1995-09-16
1997-04-02
Agrevo Uk Ltd
Fungicidal amides

EP1765768B1
(en)

*

2004-07-08
2013-11-06
AstraZeneca AB
Substituted acids for the treatment of respiratory diseases

Also Published As

Publication number
Publication date

IE34441L
(en)

1971-02-07

JPS4939275B1
(en)

1974-10-24

OA03651A
(en)

1971-12-24

AT301556B
(en)

1972-09-11

ES382564A1
(en)

1973-05-01

IE34441B1
(en)

1975-05-14

DE2064879A1
(en)

1972-02-10

PL82685B1
(en)

1975-10-31

BE754532A
(en)

1971-02-08

SU399124A3
(en)

1973-09-27

AT299211B
(en)

1972-06-12

SU370777A3
(en)

1973-02-15

IL35070A0
(en)

1970-10-30

GB1301367A
(en)

1972-12-29

ES383390A1
(en)

1973-02-16

CH516560A
(en)

1971-12-15

LU61484A1
(en)

1971-07-15

CS163771B2
(en)

1975-11-07

ZA705448B
(en)

1971-04-28

NL7011296A
(en)

1971-02-09

CS163772B2
(en)

1975-11-07

DE2039396A1
(en)

1971-02-18

FR2069831A1
(en)

1971-09-10

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Legal Events

Date
Code
Title
Description

1973-05-09
PS
Patent sealed [section 19, patents act 1949]

1983-03-09
PCNP
Patent ceased through non-payment of renewal fee

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