GB1353598A – Preparation of 11-hydroxy-ring a aromatic steroids
– Google Patents
GB1353598A – Preparation of 11-hydroxy-ring a aromatic steroids
– Google Patents
Preparation of 11-hydroxy-ring a aromatic steroids
Info
Publication number
GB1353598A
GB1353598A
GB1353598DA
GB1353598A
GB 1353598 A
GB1353598 A
GB 1353598A
GB 1353598D A
GB1353598D A
GB 1353598DA
GB 1353598 A
GB1353598 A
GB 1353598A
Authority
GB
United Kingdom
Prior art keywords
hydroxy
ring
aromatic steroids
preparation
steroids
Prior art date
1970-10-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1970-10-30
Filing date
1970-10-30
Publication date
1974-05-22
1970-10-30
Application filed by Glaxo Laboratories Ltd
filed
Critical
Glaxo Laboratories Ltd
1974-05-22
Publication of GB1353598A
publication
Critical
patent/GB1353598A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07J—STEROIDS
C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07J—STEROIDS
C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
C07J1/0051—Estrane derivatives
C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07J—STEROIDS
C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
C07J1/0051—Estrane derivatives
C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07J—STEROIDS
C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16
Abstract
1353598 Preparation of 11-hydroxy-ring A aromatic steroids GLAXO LABORATORIES Ltd 29 Oct 1971 [30 Oct 1970] 51792/70 Heading C2U 3-Hydroxy-9α-H-11α-OH ring A aromatic steroids are prepared by borohydride reduction of 3-hydroxy or acyloxy-9α-OH-11#-nitro-oxy ring A aromatic steroids. Use of epimerie 9#-ols gives mixtures of 9#-H-11#-OH and 9α-H-11#- OH products from which the latter may be isolated by chromatography. The starting materials can contain other double bonds and substituents; the latter may be concomitantly reduced. In one example a product 3-ol is etherified to give 3-methoxy-estra-1,3,5(10)- triene-11α-17#-diol which is subsequently oxidized to the corresponding 17-one. Specification 1,332,784 is referred to.
GB1353598D
1970-10-30
1970-10-30
Preparation of 11-hydroxy-ring a aromatic steroids
Expired
GB1353598A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
GB5179270
1970-10-30
Publications (1)
Publication Number
Publication Date
GB1353598A
true
GB1353598A
(en)
1974-05-22
Family
ID=10461392
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB1353598D
Expired
GB1353598A
(en)
1970-10-30
1970-10-30
Preparation of 11-hydroxy-ring a aromatic steroids
Country Status (5)
Country
Link
DE
(1)
DE2154050A1
(en)
DK
(1)
DK130836B
(en)
FR
(1)
FR2113243A5
(en)
GB
(1)
GB1353598A
(en)
NL
(1)
NL7114743A
(en)
1970
1970-10-30
GB
GB1353598D
patent/GB1353598A/en
not_active
Expired
1971
1971-10-26
NL
NL7114743A
patent/NL7114743A/xx
unknown
1971-10-26
FR
FR7138383A
patent/FR2113243A5/fr
not_active
Expired
1971-10-28
DK
DK524771A
patent/DK130836B/en
unknown
1971-10-29
DE
DE19712154050
patent/DE2154050A1/en
active
Pending
Also Published As
Publication number
Publication date
FR2113243A5
(en)
1972-06-23
DK130836C
(en)
1975-11-03
NL7114743A
(en)
1972-05-03
DK130836B
(en)
1975-04-21
DE2154050A1
(en)
1972-05-04
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Legal Events
Date
Code
Title
Description
1974-10-02
PS
Patent sealed
1977-05-25
PLNP
Patent lapsed through nonpayment of renewal fees
