GB1363293A – Process for the preparation of 14-anhydrobutalin
– Google Patents
GB1363293A – Process for the preparation of 14-anhydrobutalin
– Google Patents
Process for the preparation of 14-anhydrobutalin
Info
Publication number
GB1363293A
GB1363293A
GB5050771A
GB5050771A
GB1363293A
GB 1363293 A
GB1363293 A
GB 1363293A
GB 5050771 A
GB5050771 A
GB 5050771A
GB 5050771 A
GB5050771 A
GB 5050771A
GB 1363293 A
GB1363293 A
GB 1363293A
Authority
GB
United Kingdom
Prior art keywords
bufa
oxo
trienolide
ethoxy
oct
Prior art date
1970-10-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5050771A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Farbwerke Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1970-10-30
Filing date
1971-10-29
Publication date
1974-08-14
1971-10-29
Application filed by Hoechst AG, Farbwerke Hoechst AG
filed
Critical
Hoechst AG
1974-08-14
Publication of GB1363293A
publication
Critical
patent/GB1363293A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07J—STEROIDS
C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
Abstract
1363293 14-Anhydrobufalin synthesis FARBWERKE HOECHST AG 29 Oct 1971 [30 Oct 1970] 50507/71 Heading C2U 3# – Hydroxy – 5# – bufa – 14,20,22 – trienolide (I) is prepared from 3-ethoxy-21,21-dimethoxypregna – 3,5,14 – trien – 20 – one (V) by the sequence: V # 3 – ethoxy – 20 – methylene- 21,21 – dimethoxy – pregna – 3,5,14 – triene # 3- oxo – 20 – methylenepregna – 4,14 – dien – 21 – al # 3,21 – dioxo – 23 – carboxychola – 4,14- dienic acid dimethyl ester # the free diacid # 3,21 – dioxochola – 4,14 – dienic acid # 3- oxo – bufa – 4,14,20 – trienolide (II) # 3 – oxo- 5# – bufa – 14,20 – dienolide (III) # 3 – oxo- 5# – bufa – 14,20,22 – trienolide (IV) #I. The invention comprises (a) the process sequence II # III # IV # I ; and (b) the process step IV # I when effected using trimethyl phosphite in isopropanol in the presence of H 2 IrCl 6 .
GB5050771A
1970-10-30
1971-10-29
Process for the preparation of 14-anhydrobutalin
Expired
GB1363293A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
DE2053310A
DE2053310C3
(en)
1970-10-30
1970-10-30
Process for the preparation of 14-anhydrobufalin
Publications (1)
Publication Number
Publication Date
GB1363293A
true
GB1363293A
(en)
1974-08-14
Family
ID=5786619
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB5050771A
Expired
GB1363293A
(en)
1970-10-30
1971-10-29
Process for the preparation of 14-anhydrobutalin
Country Status (16)
Country
Link
US
(1)
US3753980A
(en)
AT
(1)
AT310360B
(en)
BE
(1)
BE774716A
(en)
CA
(1)
CA951721A
(en)
CH
(1)
CH559217A5
(en)
CS
(1)
CS167333B2
(en)
DE
(1)
DE2053310C3
(en)
DK
(1)
DK126939B
(en)
FI
(1)
FI48076C
(en)
FR
(1)
FR2113458A5
(en)
GB
(1)
GB1363293A
(en)
HU
(1)
HU162808B
(en)
IL
(1)
IL38029A
(en)
NL
(1)
NL7114652A
(en)
PL
(1)
PL81407B1
(en)
SE
(1)
SE364269B
(en)
Families Citing this family (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US4096142A
(en)
*
1972-01-04
1978-06-20
Steele Chemicals Co. Ltd.
14,19-Dioxygenated steroid compounds and their 14-dehydro analogs and process for the preparation thereof
1970
1970-10-30
DE
DE2053310A
patent/DE2053310C3/en
not_active
Expired
1971
1971-10-01
CA
CA124,162,A
patent/CA951721A/en
not_active
Expired
1971-10-25
CS
CS7498A
patent/CS167333B2/cs
unknown
1971-10-25
NL
NL7114652A
patent/NL7114652A/xx
unknown
1971-10-27
CH
CH1565871A
patent/CH559217A5/xx
not_active
IP Right Cessation
1971-10-28
FI
FI713079A
patent/FI48076C/en
active
1971-10-28
IL
IL38029A
patent/IL38029A/en
unknown
1971-10-29
DK
DK531171AA
patent/DK126939B/en
unknown
1971-10-29
AT
AT937871A
patent/AT310360B/en
not_active
IP Right Cessation
1971-10-29
HU
HUHO1429A
patent/HU162808B/hu
unknown
1971-10-29
GB
GB5050771A
patent/GB1363293A/en
not_active
Expired
1971-10-29
SE
SE13757/71A
patent/SE364269B/xx
unknown
1971-10-29
US
US00194003A
patent/US3753980A/en
not_active
Expired – Lifetime
1971-10-29
BE
BE774716A
patent/BE774716A/en
unknown
1971-10-29
PL
PL1971151294A
patent/PL81407B1/pl
unknown
1971-11-02
FR
FR7139199A
patent/FR2113458A5/fr
not_active
Expired
Also Published As
Publication number
Publication date
AT310360B
(en)
1973-09-25
DE2053310B2
(en)
1973-07-05
PL81407B1
(en)
1975-08-30
FI48076C
(en)
1974-06-10
FR2113458A5
(en)
1972-06-23
BE774716A
(en)
1972-05-02
CS167333B2
(en)
1976-04-29
CA951721A
(en)
1974-07-23
DK126939B
(en)
1973-09-03
HU162808B
(en)
1973-04-28
NL7114652A
(en)
1972-05-03
DE2053310C3
(en)
1974-02-28
IL38029A
(en)
1974-07-31
US3753980A
(en)
1973-08-21
DE2053310A1
(en)
1972-05-10
FI48076B
(en)
1974-02-28
SE364269B
(en)
1974-02-18
IL38029A0
(en)
1971-12-29
CH559217A5
(en)
1975-02-28
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Legal Events
Date
Code
Title
Description
1974-12-27
PS
Patent sealed [section 19, patents act 1949]
1977-05-25
PLNP
Patent lapsed through nonpayment of renewal fees
