GB1365806A – Phtalazone derivatives
– Google Patents
GB1365806A – Phtalazone derivatives
– Google Patents
Phtalazone derivatives
Info
Publication number
GB1365806A
GB1365806A
GB811672A
GB811672A
GB1365806A
GB 1365806 A
GB1365806 A
GB 1365806A
GB 811672 A
GB811672 A
GB 811672A
GB 811672 A
GB811672 A
GB 811672A
GB 1365806 A
GB1365806 A
GB 1365806A
Authority
GB
United Kingdom
Prior art keywords
formula
reacting
phthalazinones
alkyl
compounds
Prior art date
1935-11-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB811672A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1935-11-11
Filing date
1972-02-22
Publication date
1974-09-04
1971-02-23
Priority claimed from JP836871A
external-priority
patent/JPS5017072B1/ja
1971-02-27
Priority claimed from JP983571A
external-priority
patent/JPS5010867B1/ja
1971-02-27
Priority claimed from JP983671A
external-priority
patent/JPS5010868B1/ja
1971-02-27
Priority claimed from JP983771A
external-priority
patent/JPS5010869B1/ja
1971-08-05
Priority claimed from JP5864471A
external-priority
patent/JPS5030623B2/ja
1971-08-10
Priority claimed from JP5990471A
external-priority
patent/JPS5030624B2/ja
1971-08-10
Priority claimed from JP5990571A
external-priority
patent/JPS5030625B2/ja
1971-08-16
Priority claimed from JP46061636A
external-priority
patent/JPS5030626B2/ja
1971-08-21
Priority claimed from JP6334071A
external-priority
patent/JPS5030627B2/ja
1971-09-08
Priority claimed from JP6894071A
external-priority
patent/JPS5030628B2/ja
1971-09-09
Priority claimed from JP6925071A
external-priority
patent/JPS5030629B2/ja
1972-02-22
Application filed by Individual
filed
Critical
Individual
1972-02-23
Priority claimed from AT443873A
external-priority
patent/AT318636B/en
1974-09-04
Publication of GB1365806A
publication
Critical
patent/GB1365806A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
A—HUMAN NECESSITIES
A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
A01N57/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing heterocyclic radicals
Abstract
1365806 1(2H)-Phthalazinones M INOUE M ISHIKAWA T TSUCHIYA and T SHIMAMOTO 22 Feb 1972 [23 Feb 1971 27 Feb 1971 (3) 5 Aug 1971 10 Aug 1971 (2) 16 Aug 1971 21 Aug 1971 8 Sept 1971 9 Sept 1971] 8116/72 Heading C2C Novel 1(2H)-phthalazinones of the formula wherein R 1 is H or alkyl; R 2 is H, alkyl, cycloalkyl, alkenyl, aryl, aralkyl, dialkylaminoalkyl, furfuryl, 3-furylmethyl, pyridylmethyl or pyridyl; R 3 is H, alkyl, aryl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylsulphonyl, or arylsulphonyl; R 4 is H, halogen, alkyl or alkoxy; R 5 is H, halogen, alkyl, alkoxy, NH 2 , acylamino, alkoxycarbonyl, or carbamoyl; or R 1 and R 2 , together with the N atom to which they are attached, form a saturated heterocyclic ring optionally containing a further heteroatom; are prepared by one of the following methods: (a) compounds in which R 1 is H and R 2 is not H by reacting the appropriate 4- hydroxymethyl-1(2H)-phthalazinones with isocyanates of the formula R 2 NCO (R 2 not equal to H); (b) reacting compounds of Formula IV with compounds of the formula HNR 1 R 2 ; (c) reacting the appropriate 4-hydroxymethyl- 1(2H)-phthalazinones with phosgene and treating the resulting chloroformates with ammonia or amines of the formula HNR 1 R 2 ; (d) reacting the appropriate 4-hydroxymethyl-1(2H)-phthalazinones with carbamic acid derivatives of the formula R 1 R 2 NCOY, wherein Y is halogen, alkoxy, aryloxy, alkylthio or arylthio; (e) reacting compounds of the Formula VIII with hydrazines of the formula H 2 NNNR 3 . 4 – Phenoxycarbonyloxymethyl – 1(2H) – phthalazinone is obtained by reacting 4-hydroxymethyl-1(2H)-phthalazinone with phenyl chloroformate. o-Carbamoylbenzoylmethyl methylcarbamate is prepared by reacting methyl isocyanate with o-hydroxyacetyl benzamide resulting from the reaction between ammonia and 3,4-dihydro-4- oxo-isocoumarine. Pharmaceutical compositions comprise the novel compounds and pharmaceutically acceptable diluents or carriers. The compositions are suitable for the treatment of atherosclerotic and thrombotic diseases.
GB811672A
1935-11-11
1972-02-22
Phtalazone derivatives
Expired
GB1365806A
(en)
Applications Claiming Priority (13)
Application Number
Priority Date
Filing Date
Title
AT148072T
1935-11-11
JP836871A
JPS5017072B1
(en)
1971-02-23
1971-02-23
JP983771A
JPS5010869B1
(en)
1971-02-27
1971-02-27
JP983571A
JPS5010867B1
(en)
1971-02-27
1971-02-27
JP983671A
JPS5010868B1
(en)
1971-02-27
1971-02-27
JP5864471A
JPS5030623B2
(en)
1971-08-05
1971-08-05
JP5990471A
JPS5030624B2
(en)
1971-08-10
1971-08-10
JP5990571A
JPS5030625B2
(en)
1971-08-10
1971-08-10
JP46061636A
JPS5030626B2
(en)
1971-08-16
1971-08-16
JP6334071A
JPS5030627B2
(en)
1971-08-21
1971-08-21
JP6894071A
JPS5030628B2
(en)
1971-09-08
1971-09-08
JP6925071A
JPS5030629B2
(en)
1971-09-09
1971-09-09
AT443873A
AT318636B
(en)
1935-11-11
1972-02-23
Process for the preparation of new 4-carbamoxymethyl-1-phthalazone derivatives and their acid addition salts
Publications (1)
Publication Number
Publication Date
GB1365806A
true
GB1365806A
(en)
1974-09-04
Family
ID=27583880
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB811672A
Expired
GB1365806A
(en)
1935-11-11
1972-02-22
Phtalazone derivatives
Country Status (15)
Country
Link
AR
(3)
AR199548A1
(en)
AU
(1)
AU462374B2
(en)
BE
(1)
BE779626A
(en)
CA
(1)
CA1004673A
(en)
CH
(1)
CH575932A5
(en)
DE
(1)
DE2208325A1
(en)
DK
(1)
DK130642B
(en)
FI
(1)
FI52576C
(en)
FR
(1)
FR2126321B1
(en)
GB
(1)
GB1365806A
(en)
IE
(1)
IE36226B1
(en)
LU
(1)
LU64815A1
(en)
NL
(1)
NL7202373A
(en)
NO
(1)
NO134299C
(en)
SE
(1)
SE386167B
(en)
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
DE4333761A1
(en)
*
1993-10-04
1995-04-06
Luitpold Pharma Gmbh
Heterocyclic carbamates, process for their preparation and pharmaceuticals
1972
1972-02-08
IE
IE155/72A
patent/IE36226B1/en
unknown
1972-02-10
SE
SE7201580A
patent/SE386167B/en
unknown
1972-02-17
AR
AR240576A
patent/AR199548A1/en
active
1972-02-17
AU
AU39099/72A
patent/AU462374B2/en
not_active
Expired
1972-02-21
BE
BE779626A
patent/BE779626A/en
not_active
IP Right Cessation
1972-02-21
LU
LU64815D
patent/LU64815A1/xx
unknown
1972-02-22
NO
NO534/72A
patent/NO134299C/no
unknown
1972-02-22
FI
FI720476A
patent/FI52576C/en
active
1972-02-22
CA
CA135,307A
patent/CA1004673A/en
not_active
Expired
1972-02-22
DK
DK82272AA
patent/DK130642B/en
not_active
IP Right Cessation
1972-02-22
GB
GB811672A
patent/GB1365806A/en
not_active
Expired
1972-02-22
DE
DE19722208325
patent/DE2208325A1/de
active
Pending
1972-02-23
CH
CH258872A
patent/CH575932A5/xx
not_active
IP Right Cessation
1972-02-23
NL
NL7202373A
patent/NL7202373A/xx
not_active
Application Discontinuation
1972-02-23
FR
FR7206037A
patent/FR2126321B1/fr
not_active
Expired
1972-12-26
AR
AR245832A
patent/AR199653A1/en
active
1972-12-26
AR
AR245833A
patent/AR199654A1/en
active
Cited By (4)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
DE4333761A1
(en)
*
1993-10-04
1995-04-06
Luitpold Pharma Gmbh
Heterocyclic carbamates, process for their preparation and pharmaceuticals
WO1995009842A1
(en)
*
1993-10-04
1995-04-13
Luitpold Pharma Gmbh
Isoquinolinone-, phthalazinone-, quinazolinone- and benzotriazolinone derivatives, their preparation and their use as anti-thrombotics
EP0649839A1
(en)
*
1993-10-04
1995-04-26
LUITPOLD PHARMA GmbH
Isoquinolinone-, phthalazinone-, quinazolinone- and benzotriazolinone derivatives, their preparation and their use as anti-thrombotics
US5679677A
(en)
*
1993-10-04
1997-10-21
Luitpold Pharma Gmbh
Heterocyclic carbamates, process for their preparation and medicaments
Also Published As
Publication number
Publication date
DK130642C
(en)
1975-08-18
BE779626A
(en)
1972-06-16
IE36226B1
(en)
1976-09-15
NO134299C
(en)
1976-09-15
SE386167B
(en)
1976-08-02
FR2126321B1
(en)
1975-08-01
NO134299B
(en)
1976-06-08
AR199548A1
(en)
1974-09-13
CH575932A5
(en)
1976-05-31
DE2208325A1
(en)
1972-10-12
NL7202373A
(en)
1972-08-25
AU3909972A
(en)
1973-08-23
AR199653A1
(en)
1974-09-23
AR199654A1
(en)
1974-09-23
AU462374B2
(en)
1975-06-26
FR2126321A1
(en)
1972-10-06
LU64815A1
(en)
1972-07-05
IE36226L
(en)
1972-08-23
CA1004673A
(en)
1977-02-01
DK130642B
(en)
1975-03-17
FI52576C
(en)
1977-10-10
FI52576B
(en)
1977-06-30
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Legal Events
Date
Code
Title
Description
1975-01-15
PS
Patent sealed [section 19, patents act 1949]
1986-10-15
PCNP
Patent ceased through non-payment of renewal fee
