GB1389227A

GB1389227A – Chromone-2-carboxylic acid derivatives methods for their preparation and compositions containing them
– Google Patents

GB1389227A – Chromone-2-carboxylic acid derivatives methods for their preparation and compositions containing them
– Google Patents
Chromone-2-carboxylic acid derivatives methods for their preparation and compositions containing them

Info

Publication number
GB1389227A

GB1389227A
GB4313671A
GB4313671A
GB1389227A
GB 1389227 A
GB1389227 A
GB 1389227A
GB 4313671 A
GB4313671 A
GB 4313671A
GB 4313671 A
GB4313671 A
GB 4313671A
GB 1389227 A
GB1389227 A
GB 1389227A
Authority
GB
United Kingdom
Prior art keywords
carboxylic acid
chromone
group
compound
hydrogen
Prior art date
1971-09-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB4313671A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Fisons Ltd

Original Assignee
Fisons Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1971-09-16
Filing date
1971-09-16
Publication date
1975-04-03

1971-09-16
Application filed by Fisons Ltd
filed
Critical
Fisons Ltd

1971-09-16
Priority to GB4313671A
priority
Critical
patent/GB1389227A/en

1972-09-07
Priority to JP47089175A
priority
patent/JPS4836174A/ja

1972-09-08
Priority to US287546A
priority
patent/US3860617A/en

1972-09-11
Priority to DE2244471A
priority
patent/DE2244471A1/en

1972-09-15
Priority to FR7232701A
priority
patent/FR2154518B1/fr

1975-04-03
Publication of GB1389227A
publication
Critical
patent/GB1389227A/en

1981-05-13
Priority to JP7087181A
priority
patent/JPS574983A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system

C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings

C07D493/04—Ortho-condensed systems

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P11/00—Drugs for disorders of the respiratory system

A61P11/08—Bronchodilators

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P37/00—Drugs for immunological or allergic disorders

A61P37/08—Antiallergic agents

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds

C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition

C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates

C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring

C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups

C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings

C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems

C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring

C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4

C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings

C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems

C07D311/78—Ring systems having three or more relevant rings

C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings

C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems

C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Abstract

1389227 Chromone-2-carboxylic acid derivatives FISONS Ltd 8 Aug 1972 [16 Sept 1971] 43136/71 Heading C2C Novel compounds of Formula I in which Q and R are hydrogen or alkyl and P forms a 3 or 4 membered saturated alkylene chain or a 3 or 4 membered saturated or unsaturated chain containing an oxygen atom and an alkylene group either of which chains may carry an alkyl substituent and their pharmaceutically acceptable derivatives are prepared by (1) oyclizing a compound of formula II in which A1 is COCH 2 COCOR11 and A2 is OM or A1 is hydrogen and A 2 is in which R is hydroxyl or a group hydrolysable thereto and M is hydrogen or an alkali metal and if required hydrolysing the group R11 (2) hydrolysing a derivative of a compound I preferably an ester acid halide, amide or nitrile to the carboxylic acid, (3) cyclizing a compound IV in which T is hydroxyl and G is a 2-3 membered hydrocarbon chain substituted by an anion forming group and optionally by an alkyl group to form a compound I in which P represents a 3 or 4 membered chain containing oxygen and an alkylene group in which the oxygen is adjacent to the benzene ring . Reaction (I) with A1 representing COCH 2 COCOR11 is carried out in the presence of an acid and in an inert solvent. Reaction (1) with A2 representing OC(COOM)=CH-COOM is carried out in the presence of a dehydrating agent in anhydrous conditions or by converting the free carboxy groups to acyl halide groups and carrying out an intramolecular Friedal-Crafts reaction. 10- ethyl – cyclohexano[f] – chromone – 2 – carboxylic acid- 10 – ethyl – 2,3 – dihydropyrano[3,2 – f]- chromone – 2 – carboxylic acid; 2 – methyl – 9- oxo – 9 – H – 2,3 – dihydrofuro[2,3 – -f[[1] – benzopyran – 7 – carboxylic acid; 3- methyl – 9 – oxo- 9H – furo[2,3 – -f][1] – benzopyran – 7 – carboxylic acid are prepared. Compounds I inhibit the release or action of mediators which result from certain antibodyantigen reactions. Compounds I form with an adjuvant, diluent or carrier a pharmaceutical composition which may be administered orally or by inhalation.

GB4313671A
1971-09-16
1971-09-16
Chromone-2-carboxylic acid derivatives methods for their preparation and compositions containing them

Expired

GB1389227A
(en)

Priority Applications (6)

Application Number
Priority Date
Filing Date
Title

GB4313671A

GB1389227A
(en)

1971-09-16
1971-09-16
Chromone-2-carboxylic acid derivatives methods for their preparation and compositions containing them

JP47089175A

JPS4836174A
(en)

1971-09-16
1972-09-07

US287546A

US3860617A
(en)

1971-09-16
1972-09-08
Benzopyrans

DE2244471A

DE2244471A1
(en)

1971-09-16
1972-09-11

NEW CHROMONE COMPOUND AND METHOD FOR MAKING IT

FR7232701A

FR2154518B1
(en)

1971-09-16
1972-09-15

JP7087181A

JPS574983A
(en)

1971-09-16
1981-05-13
Manufacture of substituted chromone compound

Applications Claiming Priority (2)

Application Number
Priority Date
Filing Date
Title

GB4313671A

GB1389227A
(en)

1971-09-16
1971-09-16
Chromone-2-carboxylic acid derivatives methods for their preparation and compositions containing them

US287546A

US3860617A
(en)

1971-09-16
1972-09-08
Benzopyrans

Publications (1)

Publication Number
Publication Date

GB1389227A
true

GB1389227A
(en)

1975-04-03

Family
ID=26265058
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB4313671A
Expired

GB1389227A
(en)

1971-09-16
1971-09-16
Chromone-2-carboxylic acid derivatives methods for their preparation and compositions containing them

Country Status (5)

Country
Link

US
(1)

US3860617A
(en)

JP
(2)

JPS4836174A
(en)

DE
(1)

DE2244471A1
(en)

FR
(1)

FR2154518B1
(en)

GB
(1)

GB1389227A
(en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

GB1488707A
(en)

*

1974-07-10
1977-10-12
Fisons Ltd
5-(2-hydroxy-propoxy)-4-oxo-8-propyl-4h-1-benzopyran-2-carboxylic acid and derivatives thereof

CA1065329A
(en)

*

1974-11-30
1979-10-30
Richard Hazard
Chromone derivatives

US4159273A
(en)

*

1974-11-30
1979-06-26
Fisons Limited
Tricyclic mono-chromone-2-carboxylic acids

GB1560489A
(en)

*

1976-05-21
1980-02-06
Fisons Ltd
Pharmaceutical compositions

Family Cites Families (3)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

BE654149A
(en)

*

1964-10-08
1965-04-08

GB1230087A
(en)

*

1967-08-17
1971-04-28

CA960223A
(en)

*

1970-02-05
1974-12-31
Mervyn E. Peel
Tetrazolyl chromones

1971

1971-09-16
GB
GB4313671A
patent/GB1389227A/en
not_active
Expired

1972

1972-09-07
JP
JP47089175A
patent/JPS4836174A/ja
active
Pending

1972-09-08
US
US287546A
patent/US3860617A/en
not_active
Expired – Lifetime

1972-09-11
DE
DE2244471A
patent/DE2244471A1/en
not_active
Withdrawn

1972-09-15
FR
FR7232701A
patent/FR2154518B1/fr
not_active
Expired

1981

1981-05-13
JP
JP7087181A
patent/JPS574983A/en
active
Granted

Also Published As

Publication number
Publication date

DE2244471A1
(en)

1973-03-22

JPS5727111B2
(en)

1982-06-08

US3860617A
(en)

1975-01-14

JPS574983A
(en)

1982-01-11

FR2154518A1
(en)

1973-05-11

JPS4836174A
(en)

1973-05-28

FR2154518B1
(en)

1976-04-23

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Legal Events

Date
Code
Title
Description

1975-08-13
PS
Patent sealed [section 19, patents act 1949]

1983-03-09
PCNP
Patent ceased through non-payment of renewal fee

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