GB1389436A – 1,4-benzodiazepine derivatives and their preparation
– Google Patents
GB1389436A – 1,4-benzodiazepine derivatives and their preparation
– Google Patents
1,4-benzodiazepine derivatives and their preparation
Info
Publication number
GB1389436A
GB1389436A
GB3412574A
GB3412574A
GB1389436A
GB 1389436 A
GB1389436 A
GB 1389436A
GB 3412574 A
GB3412574 A
GB 3412574A
GB 3412574 A
GB3412574 A
GB 3412574A
GB 1389436 A
GB1389436 A
GB 1389436A
Authority
GB
United Kingdom
Prior art keywords
alkyl
compounds
preparation
benzodiazepine derivatives
imidazobenzodiazepines
Prior art date
1971-08-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3412574A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1971-08-04
Filing date
1972-07-13
Publication date
1975-04-03
1972-07-13
Application filed by Upjohn Co
filed
Critical
Upjohn Co
1975-04-03
Publication of GB1389436A
publication
Critical
patent/GB1389436A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 – C07D477/00
C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 – C07D477/00 in which the condensed system contains two hetero rings
C07D487/04—Ortho-condensed systems
A—HUMAN NECESSITIES
A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
A23K—FODDER
A23K20/00—Accessory food factors for animal feeding-stuffs
A23K20/10—Organic substances
A23K20/116—Heterocyclic compounds
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P21/00—Drugs for disorders of the muscular or neuromuscular system
A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/00—Drugs for disorders of the nervous system
A61P25/08—Antiepileptics; Anticonvulsants
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/00—Drugs for disorders of the nervous system
A61P25/20—Hypnotics; Sedatives
Abstract
1389436 Imidazobenzodiazepines UPJOHN CO 13 July 1972 [4 Aug 1971] 34125/74 Divided out of 1389434 Heading C2C Compounds of the general formula (R = H, Me, Et, Pr; R 1,6 = H, C 1-3 alkyl; R 5 =Py, 2-pyrimidyl, furyl, pyrryl, thienyl, C 1-3 alkyl, C 2-3 alkenyl, C 5-7 cycloalkyl or cycloalkenyl, R 8 R 9 Ph; R 3,4,8,9 =H, halogen, NO 2 , CN, NH 2 , CF 3 , C 1-3 alkyl, alkoxy, alkylthio, alkylsulphinyl alkylsulphonyl, or alkanoylamino, di(C 1-3 alkyl) amino), and their acid addition salts are prepared by reacting the corresponding desoxy compound with a peracid, optionally followed by salt formation. The above compounds are sedatives, hypnotics, anticonvulsants, tranquilizers and muscle relaxants, and increase growth rate, feed efficiency and milk and egg production in livestock. They may be administered in the form of pharmaceutical and veterinary preparations and feed additives containing them in associated with a carrier.
GB3412574A
1971-08-04
1972-07-13
1,4-benzodiazepine derivatives and their preparation
Expired
GB1389436A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
US16909171A
1971-08-04
1971-08-04
Publications (1)
Publication Number
Publication Date
GB1389436A
true
GB1389436A
(en)
1975-04-03
Family
ID=22614230
Family Applications (4)
Application Number
Title
Priority Date
Filing Date
GB3413874A
Expired
GB1389437A
(en)
1971-08-04
1972-07-13
1,4-benzodiazepine derivatives and their preparation
GB3412574A
Expired
GB1389436A
(en)
1971-08-04
1972-07-13
1,4-benzodiazepine derivatives and their preparation
GB3288572A
Expired
GB1389434A
(en)
1971-08-04
1972-07-13
1,4-benzodiazepine derivatives and their preparation
GB3412474A
Expired
GB1389435A
(en)
1971-08-04
1972-07-13
1,4-benzodiazepine derivatives and their preparation
Family Applications Before (1)
Application Number
Title
Priority Date
Filing Date
GB3413874A
Expired
GB1389437A
(en)
1971-08-04
1972-07-13
1,4-benzodiazepine derivatives and their preparation
Family Applications After (2)
Application Number
Title
Priority Date
Filing Date
GB3288572A
Expired
GB1389434A
(en)
1971-08-04
1972-07-13
1,4-benzodiazepine derivatives and their preparation
GB3412474A
Expired
GB1389435A
(en)
1971-08-04
1972-07-13
1,4-benzodiazepine derivatives and their preparation
Country Status (8)
Country
Link
JP
(3)
JPS5714351B1
(en)
AU
(1)
AU461139B2
(en)
BE
(1)
BE787251A
(en)
CH
(3)
CH574444A5
(en)
DE
(1)
DE2237592C2
(en)
FR
(1)
FR2150732B1
(en)
GB
(4)
GB1389437A
(en)
ZA
(1)
ZA724880B
(en)
Families Citing this family (12)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US3917627A
(en)
*
1971-08-04
1975-11-04
Upjohn Co
6-Substituted 4H-imidazo{8 1,2-a{9 {8 1,4{9 benzodiazepines and process for their production
FR2183716A1
(en)
*
1972-05-05
1973-12-21
Centre Etd Ind Pharma
Substd-6-phenyl-4h-imidazo (1,2-a)-1,4-benzo diazepines – – tranquillisers anxiolytics,sedatives and muscle-relaxants
ZA755418B
(en)
*
1974-09-11
1977-06-29
Hoffmann La Roche
Diazepine derivatives
US3910946A
(en)
*
1974-09-12
1975-10-07
Upjohn Co
4H-Imidazo{8 1,2-a{9 {8 1,4{9 benzodiazepines
GB1484968A
(en)
*
1974-11-06
1977-09-08
Parke Davis & Co
4-aryl-imidazo(1,2-alpha)pyrazolo(4,3-f)(1,4)diazepines and their production
AU509371B2
(en)
*
1975-08-07
1980-05-08
F. Hoffmann-La Roche Ag
Diazepine Derivatives
US4118386A
(en)
*
1977-04-04
1978-10-03
Hoffmann-La Roche Inc.
Synthesis of imidazo[1,5-a]diazepine-3-carboxylates
WO1994026723A2
(en)
*
1993-05-14
1994-11-24
Genentech, Inc.
ras FARNESYL TRANSFERASE INHIBITORS
WO1996023790A1
(en)
*
1995-02-02
1996-08-08
F. Hoffmann-La Roche Ag
Acetylimidazobenzodiazepines
US10266534B2
(en)
2014-06-26
2019-04-23
The Johns Hopkins University
Peripherally restricted GABA positive allosteric modulators for the treatment of irritable bowel syndrome and other ailments of the peripheral nervous system
WO2018083051A1
(en)
*
2016-11-01
2018-05-11
F. Hoffmann-La Roche Ag
1,3-dihydro-1,4-benzodiazepine-2-thiones for the treatment of cns related diseases
CN113717176B
(en)
*
2021-10-09
2022-07-05
上海再启生物技术有限公司
Method for preparing remazolam
Family Cites Families (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US3987052A
(en)
*
1969-03-17
1976-10-19
The Upjohn Company
6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines
0
BE
BE787251D
patent/BE787251A/en
not_active
IP Right Cessation
1972
1972-07-13
GB
GB3413874A
patent/GB1389437A/en
not_active
Expired
1972-07-13
GB
GB3412574A
patent/GB1389436A/en
not_active
Expired
1972-07-13
GB
GB3288572A
patent/GB1389434A/en
not_active
Expired
1972-07-13
GB
GB3412474A
patent/GB1389435A/en
not_active
Expired
1972-07-14
ZA
ZA724880A
patent/ZA724880B/en
unknown
1972-07-18
AU
AU44673/72A
patent/AU461139B2/en
not_active
Expired
1972-07-28
CH
CH1130272A
patent/CH574444A5/xx
not_active
IP Right Cessation
1972-07-28
CH
CH1435775A
patent/CH584206A5/xx
not_active
IP Right Cessation
1972-07-28
CH
CH1435675A
patent/CH591488A5/xx
not_active
IP Right Cessation
1972-07-31
DE
DE2237592A
patent/DE2237592C2/en
not_active
Expired
1972-08-03
FR
FR7228090A
patent/FR2150732B1/fr
not_active
Expired
1972-08-04
JP
JP7775772A
patent/JPS5714351B1/ja
active
Pending
1979
1979-08-02
JP
JP9817279A
patent/JPS5547686A/en
active
Granted
1980
1980-06-16
JP
JP8030780A
patent/JPS5726667A/en
active
Granted
Also Published As
Publication number
Publication date
DE2237592C2
(en)
1985-08-14
JPS5734277B2
(en)
1982-07-22
DE2237592A1
(en)
1973-02-15
FR2150732B1
(en)
1976-04-16
CH574444A5
(en)
1976-04-15
FR2150732A1
(en)
1973-04-13
JPS5732066B2
(en)
1982-07-08
JPS5714351B1
(en)
1982-03-24
CH584206A5
(en)
1977-01-31
JPS5547686A
(en)
1980-04-04
BE787251A
(en)
1973-02-05
GB1389434A
(en)
1975-04-03
GB1389437A
(en)
1975-04-03
AU4467372A
(en)
1974-01-24
AU461139B2
(en)
1975-05-15
CH591488A5
(en)
1977-09-30
GB1389435A
(en)
1975-04-03
JPS5726667A
(en)
1982-02-12
ZA724880B
(en)
1973-06-27
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Legal Events
Date
Code
Title
Description
1975-08-13
PS
Patent sealed
1985-03-06
PCNP
Patent ceased through non-payment of renewal fee
