GB1420788A – Injectable preparations
– Google Patents
GB1420788A – Injectable preparations
– Google Patents
Injectable preparations
Info
Publication number
GB1420788A
GB1420788A
GB2163973A
GB2163973A
GB1420788A
GB 1420788 A
GB1420788 A
GB 1420788A
GB 2163973 A
GB2163973 A
GB 2163973A
GB 2163973 A
GB2163973 A
GB 2163973A
GB 1420788 A
GB1420788 A
GB 1420788A
Authority
GB
United Kingdom
Prior art keywords
solution
metal hydroxide
iii
metal
acid
Prior art date
1972-05-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2163973A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ICN Switzerland AG
Original Assignee
Solco Basel AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1972-05-08
Filing date
1973-05-07
Publication date
1976-01-14
1972-05-08
Priority claimed from CH688172A
external-priority
patent/CH566138A5/en
1973-05-07
Application filed by Solco Basel AG
filed
Critical
Solco Basel AG
1976-01-14
Publication of GB1420788A
publication
Critical
patent/GB1420788A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
A61K51/04—Organic compounds
A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K2123/00—Preparations for testing in vivo
Abstract
1420788 Radioactive preparations SOLCO BASEL AG 7 May 1973 [8 May 1972 8 Feb 1973] 21639/73 Heading G6R An injectable preparation of Tc99m or In113m of high specific activity per unit volume is made by mixing a sparingly soluble metal hydroxide with a low activity solution of the radionuclide, separating the metal hydroxide with the radionuclide concentrated therein, and dissolving the metal hydroxide in a small volume of an aqueous solution of a compound which will form a chelate with the metal. The metal hydroxide may be ready-formed or may be precipitated in the low activity solution by adding a solution of a metal compound followed by an alkali. Hydroxides of Fe(II), Fe(III), Ca, Mg and Al are prepared, but hydroxides of Cr(III), Yb(III) and Co(III) are also referred to. The chelating agent may be ascorbic, citric, or lactic acid, or alternatively, ethylenediaminetetraacetic acid or diethylenetriaminepentaacetic acid, together with hydrochloric and/or acetic acid. Further examples of suitable chelating agents are given. A solution of a citrate, citrate/phosphate, or tris-(hydroxymethyl) aminomethane may be added as a buffer solution to the separated metal hydroxide either before or together with the chelateforming solution.
GB2163973A
1972-05-08
1973-05-07
Injectable preparations
Expired
GB1420788A
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
CH688172A
CH566138A5
(en)
1972-05-08
1972-05-08
Diagnostic solns contg technetium 99 or indium 113 – from solns of low concn
CH181073
1973-02-08
Publications (1)
Publication Number
Publication Date
GB1420788A
true
GB1420788A
(en)
1976-01-14
Family
ID=25688734
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB2163973A
Expired
GB1420788A
(en)
1972-05-08
1973-05-07
Injectable preparations
Country Status (16)
Country
Link
US
(1)
US3961038A
(en)
JP
(1)
JPS4954521A
(en)
AT
(1)
AT332541B
(en)
AU
(1)
AU5527973A
(en)
BE
(1)
BE799253A
(en)
DD
(1)
DD104716A5
(en)
DE
(1)
DE2322758A1
(en)
DK
(1)
DK131546C
(en)
FI
(1)
FI51547C
(en)
FR
(1)
FR2184648B1
(en)
GB
(1)
GB1420788A
(en)
HU
(1)
HU167378B
(en)
IL
(1)
IL42204A
(en)
IT
(1)
IT999520B
(en)
NL
(1)
NL7306336A
(en)
RO
(1)
RO62634A
(en)
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
DE102005031920A1
(en)
*
2005-07-07
2007-01-11
Isotopen Technologien München AG
Apparatus and method for producing a small amount of a radioactive compound
Families Citing this family (19)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US4364920A
(en)
*
1975-04-30
1982-12-21
Medi-Physics, Inc.
Stable diagnostic reagents
ZA761944B
(en)
*
1975-04-30
1977-03-30
Procter & Gamble
Stable radiographic scanning agents
US4363793A
(en)
*
1979-08-30
1982-12-14
State University Of New York
Diagnostic radiopharmaceuticals for localization in target tissues exhibiting a regional pH shift relative to surrounding tissues
JPS56125317A
(en)
1980-03-08
1981-10-01
Nippon Mejifuijitsukusu Kk
Stable radioactive diagnosticum with radioactive metallic mark
US4489054A
(en)
*
1980-04-18
1984-12-18
Research Corporation
Cationic lipophilic complexes of 99m Tc and their use for myocardial and hepatobiliary imaging
US4387087A
(en)
*
1980-04-18
1983-06-07
Research Corporation
Cationic lipophilic complexes of 99m Tc and their use for myocardial and hepatobiliary imaging
US4454106A
(en)
*
1982-06-07
1984-06-12
Gansow Otto A
Use of metal chelate conjugated monoclonal antibodies
US4472509A
(en)
*
1982-06-07
1984-09-18
Gansow Otto A
Metal chelate conjugated monoclonal antibodies
US4485086A
(en)
*
1983-04-11
1984-11-27
Wong Dennis W
Radiolabeled tumor imaging agent and method of preparation
US5061475A
(en)
*
1985-06-07
1991-10-29
Cadema Medical Products, Inc.
Composition and method of treatment of arthritis and related diseases with holmium-166 radionuclides
US4849209A
(en)
*
1985-06-07
1989-07-18
Cadema Medical Products, Inc.
Treatment of arthritis, including rheumatoid arthritis with 166 Holmium radionuclide
US4752464A
(en)
*
1985-06-07
1988-06-21
Cadema Medical Products, Inc.
Treatment of arthritis, including rheumatoid arthritis, with radioactive isotopes
US5026538A
(en)
*
1985-06-07
1991-06-25
Cadema Medical Products, Inc.
Method of treating arthritis, including rheumatoid arthritis, with 166 Holmium radionuclide
US4863964A
(en)
*
1985-07-02
1989-09-05
Biomedical Frontiers, Inc.
Method for the stabilization of deferoxamine to chelate free ions in physiological fluid
US5217998A
(en)
*
1985-07-02
1993-06-08
Biomedical Frontiers, Inc.
Composition for the stabilization of deferoxamine to chelate free ions in physiological fluid
US5672334A
(en)
*
1991-01-16
1997-09-30
Access Pharmaceuticals, Inc.
Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans
US5707604A
(en)
*
1986-11-18
1998-01-13
Access Pharmaceuticals, Inc.
Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles
US6106866A
(en)
*
1995-07-31
2000-08-22
Access Pharmaceuticals, Inc.
In vivo agents comprising cationic drugs, peptides and metal chelators with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles, including tumor sites
US6713042B2
(en)
*
2001-02-26
2004-03-30
Bristol-Myers Squibb Pharma Company
Ascorbic acid analogs for metalloradiopharmaceuticals
1973
1973-05-04
HU
HUSO1075A
patent/HU167378B/hu
unknown
1973-05-04
IL
IL42204A
patent/IL42204A/en
unknown
1973-05-04
AU
AU55279/73A
patent/AU5527973A/en
not_active
Expired
1973-05-05
DE
DE2322758A
patent/DE2322758A1/en
active
Pending
1973-05-07
JP
JP48050544A
patent/JPS4954521A/ja
active
Pending
1973-05-07
RO
RO7300074701A
patent/RO62634A/en
unknown
1973-05-07
AT
AT398673A
patent/AT332541B/en
not_active
IP Right Cessation
1973-05-07
DD
DD170660A
patent/DD104716A5/xx
unknown
1973-05-07
DK
DK249973A
patent/DK131546C/en
active
1973-05-07
NL
NL7306336A
patent/NL7306336A/xx
unknown
1973-05-07
US
US05/357,701
patent/US3961038A/en
not_active
Expired – Lifetime
1973-05-07
FR
FR7316390A
patent/FR2184648B1/fr
not_active
Expired
1973-05-07
FI
FI731450A
patent/FI51547C/en
active
1973-05-07
GB
GB2163973A
patent/GB1420788A/en
not_active
Expired
1973-05-07
IT
IT68276/73A
patent/IT999520B/en
active
1973-05-08
BE
BE130880A
patent/BE799253A/en
unknown
Cited By (3)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
DE102005031920A1
(en)
*
2005-07-07
2007-01-11
Isotopen Technologien München AG
Apparatus and method for producing a small amount of a radioactive compound
DE102005031920B4
(en)
*
2005-07-07
2007-12-20
Isotopen Technologien München AG
Apparatus and method for producing a small amount of a radioactive compound
US7605384B2
(en)
2005-07-07
2009-10-20
Isotopen Technologien Munchen Ag
Apparatus for and method of preparing a small amount of a radioactive substance combination
Also Published As
Publication number
Publication date
ATA398673A
(en)
1976-01-15
FR2184648B1
(en)
1976-12-03
AT332541B
(en)
1976-10-11
BE799253A
(en)
1973-08-31
FI51547B
(en)
1976-11-01
FI51547C
(en)
1977-02-10
NL7306336A
(en)
1973-11-12
DE2322758A1
(en)
1973-11-22
DK131546C
(en)
1976-01-12
IL42204A
(en)
1976-09-30
HU167378B
(en)
1975-09-27
FR2184648A1
(en)
1973-12-28
IT999520B
(en)
1976-03-10
JPS4954521A
(en)
1974-05-27
DD104716A5
(en)
1974-03-20
US3961038A
(en)
1976-06-01
RO62634A
(en)
1978-05-15
AU5527973A
(en)
1974-11-07
DK131546B
(en)
1975-08-04
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Legal Events
Date
Code
Title
Description
1976-05-26
PS
Patent sealed [section 19, patents act 1949]
1977-12-07
PLNP
Patent lapsed through nonpayment of renewal fees
