GB1421104A

GB1421104A – Process for preparing aryloxyacetic thiolesters and aryloxyacetic thiolesters
– Google Patents

GB1421104A – Process for preparing aryloxyacetic thiolesters and aryloxyacetic thiolesters
– Google Patents
Process for preparing aryloxyacetic thiolesters and aryloxyacetic thiolesters

Info

Publication number
GB1421104A

GB1421104A
GB1857674A
GB1857674A
GB1421104A
GB 1421104 A
GB1421104 A
GB 1421104A
GB 1857674 A
GB1857674 A
GB 1857674A
GB 1857674 A
GB1857674 A
GB 1857674A
GB 1421104 A
GB1421104 A
GB 1421104A
Authority
GB
United Kingdom
Prior art keywords
mercaptan
aryloxyacetic
group
thiolesters
acid halide
Prior art date
1973-05-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB1857674A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Individual

Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1973-05-04
Filing date
1974-04-29
Publication date
1976-01-14

1974-04-29
Application filed by Individual
filed
Critical
Individual

1976-01-14
Publication of GB1421104A
publication
Critical
patent/GB1421104A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C327/00—Thiocarboxylic acids

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K31/00—Medicinal preparations containing organic active ingredients

A61K31/21—Esters, e.g. nitroglycerine, selenocyanates

A61K31/265—Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic, or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid

Abstract

1421104 Aryloxyacetic thiolesters J BLUM 29 April 1974 [4 May 1973] 18576/74 Heading C2C The invention comprises novel compounds of the general Formula (I): where Ph is an optionally substituted aryl group; R is an organic radical containing neither phenol nor mercaptan groups; R1 is a hydrogen atom or hydrocarbon radical, preferably aliphatic; and R11 is an aliphatic, cycloaliphatic, aromatic or heteroaromatic group, which is not aliphatic, when R1 is hydrogen. In particular, the group SR is a group derived from (N-acetyl) homocystein, (N-acetyl) cystein, beta-mercaptoethanol, parachlorophenoxy-2-isobutyryl-O-mercaptoethanol or carboxymethylmercaptan. The compounds are made by process (a) in which an aqueous solution of a metallic salt of a mercaptan reacts with an optionally substituted aryloxyacetic acid halide of the formula PhOCR1R11COX, where X is halogen, or process (b) in which a substituted aryloxyacetic acid halide reacts with a mercaptan in an inert, neutral or basic organic medium, and the mercaptan and possibly phenol group or groups contained in the mercaptan react with the substituted aryloxyacetic acid halide. Pharmaceutical preparations having hypolipemic, hypocholesteiolemic, hepatoprotective, tonic, healing and mucolytic effects contain (I) as active ingredient. Administration is orally, rectally or parenterally.

GB1857674A
1973-05-04
1974-04-29
Process for preparing aryloxyacetic thiolesters and aryloxyacetic thiolesters

Expired

GB1421104A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

FR7316162A

FR2227863B1
(en)

1973-05-04
1973-05-04

Publications (1)

Publication Number
Publication Date

GB1421104A
true

GB1421104A
(en)

1976-01-14

Family
ID=9118832
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB1857674A
Expired

GB1421104A
(en)

1973-05-04
1974-04-29
Process for preparing aryloxyacetic thiolesters and aryloxyacetic thiolesters

Country Status (12)

Country
Link

JP
(1)

JPS5025536A
(en)

AT
(1)

AT333723B
(en)

BE
(1)

BE814365A
(en)

BR
(1)

BR7403549D0
(en)

DE
(1)

DE2420667A1
(en)

ES
(1)

ES425992A1
(en)

FR
(1)

FR2227863B1
(en)

GB
(1)

GB1421104A
(en)

HU
(1)

HU168005B
(en)

LU
(1)

LU69968A1
(en)

NL
(1)

NL7406077A
(en)

OA
(1)

OA04703A
(en)

1973

1973-05-04
FR
FR7316162A
patent/FR2227863B1/fr
not_active
Expired

1974

1974-04-29
BE
BE6044563A
patent/BE814365A/en
unknown

1974-04-29
GB
GB1857674A
patent/GB1421104A/en
not_active
Expired

1974-04-29
DE
DE2420667A
patent/DE2420667A1/en
not_active
Withdrawn

1974-04-30
LU
LU69968A
patent/LU69968A1/xx
unknown

1974-04-30
BR
BR3549/74A
patent/BR7403549D0/en
unknown

1974-05-02
JP
JP49050182A
patent/JPS5025536A/ja
active
Pending

1974-05-02
OA
OA55193A
patent/OA04703A/en
unknown

1974-05-03
AT
AT365374A
patent/AT333723B/en
not_active
IP Right Cessation

1974-05-03
HU
HUBU715A
patent/HU168005B/hu
unknown

1974-05-04
ES
ES425992A
patent/ES425992A1/en
not_active
Expired

1974-05-06
NL
NL7406077A
patent/NL7406077A/xx
not_active
Application Discontinuation

Also Published As

Publication number
Publication date

ES425992A1
(en)

1976-07-01

OA04703A
(en)

1980-08-31

NL7406077A
(en)

1974-11-06

AT333723B
(en)

1976-12-10

FR2227863B1
(en)

1976-07-02

DE2420667A1
(en)

1974-11-21

BE814365A
(en)

1974-08-16

FR2227863A1
(en)

1974-11-29

JPS5025536A
(en)

1975-03-18

BR7403549D0
(en)

1974-11-19

LU69968A1
(en)

1974-08-06

HU168005B
(en)

1976-02-28

ATA365374A
(en)

1976-04-15

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Legal Events

Date
Code
Title
Description

1976-05-26
PS
Patent sealed

1981-01-14
PCNP
Patent ceased through non-payment of renewal fee

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