GB1457022A – Esters of oxyalkyltheophyllines the preparation thereof and pharmaceutical compositions containint them
– Google Patents
GB1457022A – Esters of oxyalkyltheophyllines the preparation thereof and pharmaceutical compositions containint them
– Google Patents
Esters of oxyalkyltheophyllines the preparation thereof and pharmaceutical compositions containint them
Info
Publication number
GB1457022A
GB1457022A
GB804174A
GB804174A
GB1457022A
GB 1457022 A
GB1457022 A
GB 1457022A
GB 804174 A
GB804174 A
GB 804174A
GB 804174 A
GB804174 A
GB 804174A
GB 1457022 A
GB1457022 A
GB 1457022A
Authority
GB
United Kingdom
Prior art keywords
formula
oxyalkyltheophyllines
esters
hydrogen
pharmaceutical compositions
Prior art date
1973-02-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB804174A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ludwig Merckle GmbH and Co KG Chem Pharm Fabrik
Original Assignee
Ludwig Merckle GmbH and Co KG Chem Pharm Fabrik
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1973-02-22
Filing date
1974-02-21
Publication date
1976-12-01
1974-02-21
Application filed by Ludwig Merckle GmbH and Co KG Chem Pharm Fabrik
filed
Critical
Ludwig Merckle GmbH and Co KG Chem Pharm Fabrik
1976-12-01
Publication of GB1457022A
publication
Critical
patent/GB1457022A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D473/00—Heterocyclic compounds containing purine ring systems
C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
Abstract
1457022 Esters of oxyalkyltheophyllines LUDWIG MERCKLE KG 21 Feb 1974 [22 Feb 1973] 8041/74 Heading C2C Novel compounds of the Formula I wherein X is halogen or trifluoromethyl, R 2 is hydrogen, C 1-5 aliphatic hydrocarbon or a halophenoxy group of the formula where X is as defined above, R3 is hydrogen or a C 1-5 -aliphatic hydrocarbon, R 1 is hydrogen or a halophenoxyalkane carboxylic acid residue of the formula where R 2 , R 3 and X are as defined above and n is 0 or 1 may be prepared by esterifying an acid of the Formula II or a reactive derivative thereof with either (a) a 7-(2-hydroxyethyl)-theophylline or (b) 7-(2,3- dihydroxyprop) – theophylline or a reactive derivative of (a) or (b). Pharmaceutical compositions of the compounds I with the usual excipients have cholesterol and lipid lowering action and peripheral and vaso-dilatory effects when administered orally or rectally.
GB804174A
1973-02-22
1974-02-21
Esters of oxyalkyltheophyllines the preparation thereof and pharmaceutical compositions containint them
Expired
GB1457022A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
DE2308826A
DE2308826C3
(en)
1973-02-22
1973-02-22
Phenoxyalkanecarboxylic acid esters of oxyalkyl theophyllines, process for their preparation and pharmaceuticals
Publications (1)
Publication Number
Publication Date
GB1457022A
true
GB1457022A
(en)
1976-12-01
Family
ID=5872766
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB804174A
Expired
GB1457022A
(en)
1973-02-22
1974-02-21
Esters of oxyalkyltheophyllines the preparation thereof and pharmaceutical compositions containint them
Country Status (8)
Country
Link
US
(1)
US3984413A
(en)
AT
(1)
AT328463B
(en)
BE
(1)
BE811489A
(en)
CH
(1)
CH590864A5
(en)
DE
(1)
DE2308826C3
(en)
FR
(1)
FR2218885B1
(en)
GB
(1)
GB1457022A
(en)
NL
(1)
NL182145C
(en)
Families Citing this family (14)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
NL7416412A
(en)
1973-12-27
1975-07-01
Siegfried Ag
PROCESS FOR PREPARING NEW CHOLESTEROL-GENERAL COMPOUNDS.
US4060617A
(en)
*
1976-04-01
1977-11-29
Johann A. Wulfing
Esters of the ophyllinylacetic acid
GB1527543A
(en)
*
1976-04-15
1978-10-04
Degussa
Basically substituted xanthine derivatives
US4246264A
(en)
*
1980-01-17
1981-01-20
Ludwig Merckle, K.G., Chem. Pharm. Fabrik
Treatment of hyperuricaemia with etofylline clofibrate
US4263301A
(en)
*
1980-01-24
1981-04-21
Shell Oil Company
β-Phenyl-β-hydroxyethylaminoalkyltheophyllines as inhibitors of biosynthesis of triglycerides
DE3037391A1
(en)
*
1980-10-03
1982-05-19
King Consult GmbH, 5000 Köln
ESTERS OF 7-HYDROXYALKYL-1,3-DIMETHYLXANTHINES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A LIPID-REDUCING AGENT
ATE14584T1
(en)
*
1981-03-11
1985-08-15
Merckle Kg Chem Pharm L
PROCESS FOR THE PREPARATION OF PHENOXYALCANCARBONIC ACID ESTERS OF HYDROXYAETHYLTHEOPHYLLINE.
IT1203656B
(en)
*
1983-06-10
1989-02-15
Medosan Ind Biochimi
PLATELET, ANTI-INFLAMMATORY AND BRONCOLITICS ANTI-AGGREGATING ACTIVITY OF AROYLPIRROL AND PYRYLPHENYL ACETIC OF THE 7 (W-OSSIALCHIL) THEOPHYLLINE
WO1995022546A1
(en)
*
1994-02-18
1995-08-24
Cell Therapeutics, Inc.
Intracellular signalling mediators
US6083497A
(en)
1997-11-05
2000-07-04
Geltex Pharmaceuticals, Inc.
Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
NZ543741A
(en)
2003-05-30
2009-10-30
Ranbaxy Lab Ltd
Substituted pyrrole derivatives and their use as HMG-Co inhibitors
SG166829A1
(en)
2005-11-08
2010-12-29
Ranbaxy Lab Ltd
Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
TW201628625A
(en)
2015-02-06
2016-08-16
英特賽普醫藥品公司
Pharmaceutical compositions for combination therapy
CN114144185A
(en)
2019-05-30
2022-03-04
英特塞普特医药品公司
Pharmaceutical composition comprising an FXR agonist and a fibrate for the treatment of cholestatic liver diseases
Family Cites Families (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
DE1106327B
(en)
*
1955-12-14
1961-05-10
Lannacher Heilmittel
Process for the preparation of 7-ª-oxyaethyltheophylline nicotinic acid ester
1973
1973-02-22
DE
DE2308826A
patent/DE2308826C3/en
not_active
Expired
1974
1974-02-12
NL
NLAANVRAGE7401884,A
patent/NL182145C/en
active
Search and Examination
1974-02-19
CH
CH228274A
patent/CH590864A5/xx
not_active
IP Right Cessation
1974-02-19
AT
AT133174A
patent/AT328463B/en
not_active
IP Right Cessation
1974-02-21
FR
FR7405931A
patent/FR2218885B1/fr
not_active
Expired
1974-02-21
GB
GB804174A
patent/GB1457022A/en
not_active
Expired
1974-02-21
US
US05/444,666
patent/US3984413A/en
not_active
Expired – Lifetime
1974-02-22
BE
BE141319A
patent/BE811489A/en
not_active
IP Right Cessation
Also Published As
Publication number
Publication date
US3984413A
(en)
1976-10-05
FR2218885B1
(en)
1976-09-03
BE811489A
(en)
1974-06-17
NL182145C
(en)
1988-01-18
AT328463B
(en)
1976-03-25
DE2308826A1
(en)
1974-10-10
FR2218885A1
(en)
1974-09-20
CH590864A5
(en)
1977-08-31
ATA133174A
(en)
1975-06-15
DE2308826C3
(en)
1980-03-27
DE2308826B2
(en)
1979-07-26
NL7401884A
(en)
1974-08-26
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Legal Events
Date
Code
Title
Description
1977-04-14
PS
Patent sealed [section 19, patents act 1949]
1994-03-23
PE20
Patent expired after termination of 20 years
Effective date:
19940220
