GB1476698A – Quinazolinone derivatives and therapeutic compositions containing them
– Google Patents
GB1476698A – Quinazolinone derivatives and therapeutic compositions containing them
– Google Patents
Quinazolinone derivatives and therapeutic compositions containing them
Info
Publication number
GB1476698A
GB1476698A
GB4447974A
GB4447974A
GB1476698A
GB 1476698 A
GB1476698 A
GB 1476698A
GB 4447974 A
GB4447974 A
GB 4447974A
GB 4447974 A
GB4447974 A
GB 4447974A
GB 1476698 A
GB1476698 A
GB 1476698A
Authority
GB
United Kingdom
Prior art keywords
quinazolinone
nitrobenzoyl
fluoromethyl
tolyl
pharmaceutically acceptable
Prior art date
1973-10-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4447974A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1973-10-15
Filing date
1974-10-14
Publication date
1977-06-16
1974-10-14
Application filed by Tanabe Seiyaku Co Ltd
filed
Critical
Tanabe Seiyaku Co Ltd
1977-06-16
Publication of GB1476698A
publication
Critical
patent/GB1476698A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
C07D239/72—Quinazolines; Hydrogenated quinazolines
C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
C07D239/88—Oxygen atoms
C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
Abstract
1476698 Quinazolinone derivatives and pharmaceutical uses thereof TANABE SEIYAKU CO Ltd 14 Oct 1974 [15 Oct 1973] 44479/74 Heading C2C The invention comprises 2-fluoromethyl-3- (o – tolyl) – 6 – amino – 4(3H) – quinazolinone or a pharmaceutically acceptable acid addition salt thereof. This compound is obtained by reducing 2 – fluoromethyl – 3 – (o – tolyl) – 6 – nitro- 4(3H)-quinazolinone, and if required, further converting the product compound to a pharmaceutically acceptable acid addition salt thereof. The following intermediates are prepared. N – (2 – fluoroacetamido – 5 – nitrobenzoyl) – otoluidine by treating N – (2 – amino – 5 – nitrobenzoyl)-o-toluidine with fluoroacetyl chloride. 2 – Fluoromethyl – 3 – (o – tolyl) – 6 – nitro – 4- (3H)-quinazolinone by treating N-(2-fluoroacetamido – 5 – nitrobenzoyl) – o – toluidine with acetic anhydride and acetic acid. The invention also comprises a therapeutic composition which contains as an active ingredient a compound according to the invention in admixture with a pharmaceutically acceptable carrier therefor.
GB4447974A
1973-10-15
1974-10-14
Quinazolinone derivatives and therapeutic compositions containing them
Expired
GB1476698A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
JP48115512A
JPS5215599B2
(en)
1973-10-15
1973-10-15
Publications (1)
Publication Number
Publication Date
GB1476698A
true
GB1476698A
(en)
1977-06-16
Family
ID=14664345
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB4447974A
Expired
GB1476698A
(en)
1973-10-15
1974-10-14
Quinazolinone derivatives and therapeutic compositions containing them
Country Status (6)
Country
Link
US
(1)
US3966731A
(en)
JP
(1)
JPS5215599B2
(en)
BE
(1)
BE853031Q
(en)
CH
(1)
CH605831A5
(en)
FR
(1)
FR2247246B1
(en)
GB
(1)
GB1476698A
(en)
Families Citing this family (8)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
JPS5920670B2
(en)
*
1976-04-10
1984-05-15
田辺製薬株式会社
Production method of quinazolinone derivatives
JPS5587672U
(en)
*
1978-12-12
1980-06-17
JPS59128376A
(en)
*
1983-01-13
1984-07-24
Tanabe Seiyaku Co Ltd
Quinazolinone derivative and its preparation
JPS60178817A
(en)
*
1984-02-22
1985-09-12
Tanabe Seiyaku Co Ltd
Muscle relaxant
US4721714A
(en)
*
1985-07-12
1988-01-26
Tanabe Seiyaku Co., Ltd.
Anti-vertigo drug
JP3486752B2
(en)
*
1995-08-30
2004-01-13
株式会社大塚製薬工場
Method for producing quinazolin-4-one derivative
KR100345568B1
(en)
*
2000-04-28
2002-07-26
한올제약주식회사
A new method for the synthesis of 2-(fluoromethyl)-3-aryl-4(3h)-quinazolinone derivatives
CN103613549B
(en)
*
2013-10-11
2016-04-20
浙江工业大学
A kind of preparation method of afloqualone
Family Cites Families (3)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
FR882430A
(en)
*
1941-05-29
1943-06-02
Philips Nv
Artificial resin-based plastics and method of manufacturing them
FR947842A
(en)
*
1946-06-13
1949-07-13
Packing box
US3414573A
(en)
*
1962-06-27
1968-12-03
Squibb & Sons Inc
Certain 3-alkylphenyl-quinazolones
1973
1973-10-15
JP
JP48115512A
patent/JPS5215599B2/ja
not_active
Expired
1974
1974-09-30
US
US05/510,577
patent/US3966731A/en
not_active
Expired – Lifetime
1974-10-14
GB
GB4447974A
patent/GB1476698A/en
not_active
Expired
1974-10-14
FR
FR7434505A
patent/FR2247246B1/fr
not_active
Expired
1974-10-15
CH
CH1382274A
patent/CH605831A5/xx
not_active
IP Right Cessation
1977
1977-03-30
BE
BE176245A
patent/BE853031Q/en
not_active
IP Right Cessation
Also Published As
Publication number
Publication date
CH605831A5
(en)
1978-10-13
DE2449113B2
(en)
1976-05-20
US3966731A
(en)
1976-06-29
BE853031Q
(en)
1977-07-18
JPS5064283A
(en)
1975-05-31
DE2449113A1
(en)
1975-04-24
FR2247246A1
(en)
1975-05-09
FR2247246B1
(en)
1978-07-21
JPS5215599B2
(en)
1977-04-30
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Therapeutic compositions
Legal Events
Date
Code
Title
Description
1977-10-26
PS
Patent sealed [section 19, patents act 1949]
1989-02-08
704A
Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
1994-11-09
PE20
Patent expired after termination of 20 years
Effective date:
19941013
