GB1479873A – Benzothienyl aminoethyl ketones method of preparation thereof and their application in therapeutics
– Google Patents
GB1479873A – Benzothienyl aminoethyl ketones method of preparation thereof and their application in therapeutics
– Google Patents
Benzothienyl aminoethyl ketones method of preparation thereof and their application in therapeutics
Info
Publication number
GB1479873A
GB1479873A
GB11973/76A
GB1197376A
GB1479873A
GB 1479873 A
GB1479873 A
GB 1479873A
GB 11973/76 A
GB11973/76 A
GB 11973/76A
GB 1197376 A
GB1197376 A
GB 1197376A
GB 1479873 A
GB1479873 A
GB 1479873A
Authority
GB
United Kingdom
Prior art keywords
acid
bromide
benzothienyl
compound
formula
Prior art date
1975-04-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB11973/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Innothera SAS
Original Assignee
Laboratoires Innothera SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1975-04-03
Filing date
1976-03-25
Publication date
1977-07-13
1976-03-25
Application filed by Laboratoires Innothera SAS
filed
Critical
Laboratoires Innothera SAS
1977-07-13
Publication of GB1479873A
publication
Critical
patent/GB1479873A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
C07D333/58—Radicals substituted by nitrogen atoms
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/00—Drugs for disorders of the nervous system
A61P25/04—Centrally acting analgesics, e.g. opioids
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P7/00—Drugs for disorders of the blood or the extracellular fluid
A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P9/00—Drugs for disorders of the cardiovascular system
A61P9/08—Vasodilators for multiple indications
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P9/00—Drugs for disorders of the cardiovascular system
A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
1479873 Benzothienyl aminoethylketones INNOTHERA 25 March 1976 [3 April 1975] 11973/76 Heading C2C Novel compounds of Formula I wherein R 1 and R 2 each designate an unsaturated or saturated alkyl radical, having from 1 to 4 carbon atoms, or together with the nitrogen atom to which they are attached, form a heterocyclic radical selected from: pyrrolidino, piperidino, perhydroazepino; and morpholino; and HX represents an acid compound selected from the following: hydrochloric acid, hydrobromic acid, sulphuric acid, phosphoric acid or boric acid; oxalic, maleic, malic, fumaric, citric, embonic, methane, sulphonic, acetylsalicylic, nicotinic, parachlorophenoxyacetic or parachlorophenoxyisobutyric acid; methyl bromide, methyl iodide, ethyl bromide, butyl bromide or benzyl bromide are prepared by reacting a compound of Formula II with an amine HNR 1 .R 2 and in a Mannich reaction. Pharmaceutical compositions in conventional forms and having spasmolytic, analgesic, antiinflammatory and vasodilatory activity comprise an above novel compound and a carrier or diluent.
GB11973/76A
1975-04-03
1976-03-25
Benzothienyl aminoethyl ketones method of preparation thereof and their application in therapeutics
Expired
GB1479873A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
FR7510421A
FR2305981A1
(en)
1975-04-03
1975-04-03
NEW BENZOTHIENYL AMINOETHYL KETONES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
Publications (1)
Publication Number
Publication Date
GB1479873A
true
GB1479873A
(en)
1977-07-13
Family
ID=9153480
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB11973/76A
Expired
GB1479873A
(en)
1975-04-03
1976-03-25
Benzothienyl aminoethyl ketones method of preparation thereof and their application in therapeutics
Country Status (6)
Country
Link
US
(1)
US4079140A
(en)
JP
(1)
JPS51143660A
(en)
CA
(1)
CA1070304A
(en)
DE
(1)
DE2614137C2
(en)
FR
(1)
FR2305981A1
(en)
GB
(1)
GB1479873A
(en)
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
EP0004000A1
(en)
*
1978-02-22
1979-09-19
Nippon Zoki Pharmaceutical Co. Ltd.
New propanone derivatives, process for producing thereof and pharmaceutical compositions containing these derivatives as active ingredients
Families Citing this family (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
FR2670492B1
(en)
*
1990-12-12
1994-11-04
Lafon Labor
NEW AMINOALKYLCETONE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATIONS.
Family Cites Families (4)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US3417087A
(en)
*
1965-12-27
1968-12-17
Research Corp
3(aminopropionyl)benzothiophenes
US3903092A
(en)
*
1966-03-02
1975-09-02
Aspro Nicholas Ltd
2-Tertiaryamino-1-(benzo{8 b{9 thienyl)ethanols
GB1174411A
(en)
*
1966-03-02
1969-12-17
Aspro Nicholas Ltd
Novel Benzothiophen Compounds, Compositions containing them and processes for their manufacture
US3514465A
(en)
*
1966-12-30
1970-05-26
Degussa
Certain thiazolyl- and pyridinylaminoketones
1975
1975-04-03
FR
FR7510421A
patent/FR2305981A1/en
active
Granted
1976
1976-03-25
GB
GB11973/76A
patent/GB1479873A/en
not_active
Expired
1976-03-31
US
US05/672,110
patent/US4079140A/en
not_active
Expired – Lifetime
1976-04-01
DE
DE2614137A
patent/DE2614137C2/en
not_active
Expired
1976-04-02
CA
CA249,477A
patent/CA1070304A/en
not_active
Expired
1976-04-02
JP
JP51037002A
patent/JPS51143660A/en
active
Granted
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
EP0004000A1
(en)
*
1978-02-22
1979-09-19
Nippon Zoki Pharmaceutical Co. Ltd.
New propanone derivatives, process for producing thereof and pharmaceutical compositions containing these derivatives as active ingredients
Also Published As
Publication number
Publication date
JPS6154797B2
(en)
1986-11-25
FR2305981B1
(en)
1979-08-10
FR2305981A1
(en)
1976-10-29
JPS51143660A
(en)
1976-12-10
US4079140A
(en)
1978-03-14
DE2614137A1
(en)
1976-10-14
CA1070304A
(en)
1980-01-22
DE2614137C2
(en)
1983-02-03
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Legal Events
Date
Code
Title
Description
1977-11-23
PS
Patent sealed [section 19, patents act 1949]
1989-11-22
PCNP
Patent ceased through non-payment of renewal fee
