GB1481650A – Chemical processes and products
– Google Patents
GB1481650A – Chemical processes and products
– Google Patents
Chemical processes and products
Info
Publication number
GB1481650A
GB1481650A
GB18978/75A
GB1897875A
GB1481650A
GB 1481650 A
GB1481650 A
GB 1481650A
GB 18978/75 A
GB18978/75 A
GB 18978/75A
GB 1897875 A
GB1897875 A
GB 1897875A
GB 1481650 A
GB1481650 A
GB 1481650A
Authority
GB
United Kingdom
Prior art keywords
virus
cell
attenuated
preparing
glutamic acid
Prior art date
1975-05-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB18978/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1975-05-06
Filing date
1975-05-06
Publication date
1977-08-03
1975-05-06
Application filed by Merck and Co Inc
filed
Critical
Merck and Co Inc
1975-05-06
Priority to GB18978/75A
priority
Critical
patent/GB1481650A/en
1977-08-03
Publication of GB1481650A
publication
Critical
patent/GB1481650A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K39/00—Medicinal preparations containing antigens or antibodies
A61K39/12—Viral antigens
A61K39/245—Herpetoviridae, e.g. herpes simplex virus
A61K39/25—Varicella-zoster virus
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K39/00—Medicinal preparations containing antigens or antibodies
A61K39/12—Viral antigens
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K39/00—Medicinal preparations containing antigens or antibodies
A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
A61K2039/525—Virus
A61K2039/5254—Virus avirulent or attenuated
C—CHEMISTRY; METALLURGY
C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
C12N2710/00011—Details
C12N2710/16011—Herpesviridae
C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
C—CHEMISTRY; METALLURGY
C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
C12N2710/00011—Details
C12N2710/16011—Herpesviridae
C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
C12N2710/16761—Methods of inactivation or attenuation
C12N2710/16764—Methods of inactivation or attenuation by serial passage
Abstract
1481650 Preparing an attenuated cell-free varicella virus MERCK & CO INC 6 May 1975 18978/75 Heading A5B A method of preparing a live attenuated, cell-free varicella virus useful as an antigen in a vaccine comprises serially passaging the virulent virus at 30‹-38‹C in a tissue culture preparation selected from human and animal diploid cell strains and primary cells of simian origin a sufficient number of times to attenuate the virus followed by release of the attenuated virus from the infected cell by sonication in the presence of a stabiliser comprising sucrose, albumin and phosphate together with glutamine, glutamic acid or a salt of glutamic acid.
GB18978/75A
1975-05-06
1975-05-06
Chemical processes and products
Expired
GB1481650A
(en)
Priority Applications (1)
Application Number
Priority Date
Filing Date
Title
GB18978/75A
GB1481650A
(en)
1975-05-06
1975-05-06
Chemical processes and products
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
GB18978/75A
GB1481650A
(en)
1975-05-06
1975-05-06
Chemical processes and products
Publications (1)
Publication Number
Publication Date
GB1481650A
true
GB1481650A
(en)
1977-08-03
Family
ID=10121704
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB18978/75A
Expired
GB1481650A
(en)
1975-05-06
1975-05-06
Chemical processes and products
Country Status (1)
Country
Link
GB
(1)
GB1481650A
(en)
Cited By (4)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
EP0043847A1
(en)
*
1980-01-25
1982-01-20
The Wistar Institute Of Anatomy And Biology
Highly attenuated varicella virus vaccine and production thereof
EP0290197A2
(en)
*
1987-05-04
1988-11-09
Merck & Co. Inc.
Stable lyophilized live herpes virus vaccine
WO1993024616A1
(en)
*
1992-06-04
1993-12-09
Merck & Co., Inc.
Process for attenuated varicella zoster virus vaccine production
US5360736A
(en)
*
1992-06-04
1994-11-01
Merck & Co., Inc.
Process for attenuated varicella zoster virus vaccine production
1975
1975-05-06
GB
GB18978/75A
patent/GB1481650A/en
not_active
Expired
Cited By (7)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
EP0043847A1
(en)
*
1980-01-25
1982-01-20
The Wistar Institute Of Anatomy And Biology
Highly attenuated varicella virus vaccine and production thereof
EP0043847A4
(en)
*
1980-01-25
1982-07-06
Wistar Inst
Highly attenuated varicella virus vaccine and production thereof.
EP0290197A2
(en)
*
1987-05-04
1988-11-09
Merck & Co. Inc.
Stable lyophilized live herpes virus vaccine
EP0290197A3
(en)
*
1987-05-04
1989-10-18
Merck & Co. Inc.
Stable lyophilized live herpes virus vaccine
WO1993024616A1
(en)
*
1992-06-04
1993-12-09
Merck & Co., Inc.
Process for attenuated varicella zoster virus vaccine production
US5360736A
(en)
*
1992-06-04
1994-11-01
Merck & Co., Inc.
Process for attenuated varicella zoster virus vaccine production
US5607852A
(en)
*
1992-06-04
1997-03-04
Merch & Co., Inc.
Process for attenuated varicella zoster virus vaccine production
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Legal Events
Date
Code
Title
Description
1977-12-21
PS
Patent sealed
1987-12-23
PCNP
Patent ceased through non-payment of renewal fee
