GB1486832A

GB1486832A – Prostanoic acid derivatives
– Google Patents

GB1486832A – Prostanoic acid derivatives
– Google Patents
Prostanoic acid derivatives

Info

Publication number
GB1486832A

GB1486832A
GB34334/74A
GB3433474A
GB1486832A
GB 1486832 A
GB1486832 A
GB 1486832A
GB 34334/74 A
GB34334/74 A
GB 34334/74A
GB 3433474 A
GB3433474 A
GB 3433474A
GB 1486832 A
GB1486832 A
GB 1486832A
Authority
GB
United Kingdom
Prior art keywords
alkoxy
vinylene
alkylidene
pharmaceutically
compounds
Prior art date
1974-08-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB34334/74A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Imperial Chemical Industries Ltd

Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1974-08-05
Filing date
1974-08-05
Publication date
1977-09-28

1974-08-05
Application filed by Imperial Chemical Industries Ltd
filed
Critical
Imperial Chemical Industries Ltd

1974-08-05
Priority to GB34334/74A
priority
Critical
patent/GB1486832A/en

1975-07-11
Priority to IE1550/75A
priority
patent/IE43198B1/en

1975-07-14
Priority to ZA00754491A
priority
patent/ZA754491B/en

1975-07-15
Priority to CA231,547A
priority
patent/CA1067490A/en

1975-07-16
Priority to IN1391/CAL/75A
priority
patent/IN141386B/en

1975-07-16
Priority to AU83102/75A
priority
patent/AU502146B2/en

1975-07-30
Priority to NL7509078A
priority
patent/NL7509078A/en

1975-07-31
Priority to FI752196A
priority
patent/FI752196A/fi

1975-08-04
Priority to SE7508779A
priority
patent/SE7508779L/en

1975-08-04
Priority to FR7524249A
priority
patent/FR2281101A1/en

1975-08-04
Priority to NO752734A
priority
patent/NO752734L/no

1975-08-04
Priority to BE158923A
priority
patent/BE832098A/en

1975-08-05
Priority to AT606175A
priority
patent/ATA606175A/en

1975-08-05
Priority to DK354575A
priority
patent/DK354575A/en

1975-08-05
Priority to DE19752534989
priority
patent/DE2534989A1/en

1975-08-05
Priority to JP50095328A
priority
patent/JPS51125042A/en

1975-08-05
Priority to DD187691A
priority
patent/DD124595A5/xx

1977-09-28
Publication of GB1486832A
publication
Critical
patent/GB1486832A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom

C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems

C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered

C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins Analogues or derivatives thereof

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins Analogues or derivatives thereof

C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups

C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins Analogues or derivatives thereof

C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups

C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings

C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

C07D309/10—Oxygen atoms

C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers

Abstract

1486832 Compositions containing prostaglandins IMPERIAL CHEMICAL INDUSTRIES Ltd 7 July 1975 [5 Aug 1974] 34334/74 Heading A5B [Also in Divisions C2 and C3] Pharmaceutically and veterinary compositions in a form suitable for oral, parenteral, rectal, vaginal administration or for inhalation, contain prostaglandins of the formula I wherein either R’ is carboxy hydroxymethyl or (C 1-10 alkoxy) carbonyl, R4 is OH and R5 is H 1 or R1 is carboxy or (C 1-10 alkoxy) carbonyl and R4 and R5 together form an oxo radical; R2 is OH or C 1-4 alkoxy; Y is ethylene or trans-vinylene, either A is ethylene or vinylene and X is C 1-6 alkylidene-oxy wherein the alkylidene is bonded to CHR and the oxygen is bonded to R3, or C 1-6 alkylidene, or A is vinylene and X is a direct bond; and R3 is phenyl or naphthyl optionally substituted by one or two halogen atoms, NO2, OH, CF 3 , phenyl, C 1-5 alkyl, di(C 1-5 alkyl) amino, C 2-5 alkenyl or C 1-5 alkoxy radicals, or for these compounds wherein R’ is carboxy the pharmaceutically or veterinary acceptable salts thereof together with pharmaceutically or veterinarily acceptable diluents or carriers. The compounds may be used in combination, or concurrently with uterine stimulants, for example, oxytosin, or gonadotrophins, for example pregnant mare serum gonadotrophin or human chorionic gonadotrophin. The compounds are used in the induction of labour, the control of the oestrus cycle, as contraceptives, as hypotensives, for the relief of bronchospasm, or as inhibitors of gastric secretion or blood platelet aggregation.

GB34334/74A
1974-08-05
1974-08-05
Prostanoic acid derivatives

Expired

GB1486832A
(en)

Priority Applications (17)

Application Number
Priority Date
Filing Date
Title

GB34334/74A

GB1486832A
(en)

1974-08-05
1974-08-05
Prostanoic acid derivatives

IE1550/75A

IE43198B1
(en)

1974-08-05
1975-07-11
Prostanoic acid derivatives

ZA00754491A

ZA754491B
(en)

1974-08-05
1975-07-14
Prostanoic acid derivatives

CA231,547A

CA1067490A
(en)

1974-08-05
1975-07-15
Prostanoic acid derivatives

IN1391/CAL/75A

IN141386B
(en)

1974-08-05
1975-07-16

AU83102/75A

AU502146B2
(en)

1974-08-05
1975-07-16
11-epi-prostanoic acid derivatives

NL7509078A

NL7509078A
(en)

1974-08-05
1975-07-30

PROCESS FOR THE PREPARATION OF PROSTANIC ACID DERIVATIVES.

FI752196A

FI752196A
(en)

1974-08-05
1975-07-31

SE7508779A

SE7508779L
(en)

1974-08-05
1975-08-04

WAY TO PRODUCE PROSTANIC ACID DERIVATIVES

FR7524249A

FR2281101A1
(en)

1974-08-05
1975-08-04

PROSTANOIC ACID DERIVATIVES

NO752734A

NO752734L
(en)

1974-08-05
1975-08-04

BE158923A

BE832098A
(en)

1974-08-05
1975-08-04

PROSTANOIC ACID DERIVATIVES

AT606175A

ATA606175A
(en)

1974-08-05
1975-08-05

METHOD FOR PRODUCING NEW PROSTANIC ACID DERIVATIVES AND THEIR SALTS

DK354575A

DK354575A
(en)

1974-08-05
1975-08-05

PROSTANIC ACID DERIVATIVES

DE19752534989

DE2534989A1
(en)

1974-08-05
1975-08-05

PROSTANIC ACID DERIVATIVES

JP50095328A

JPS51125042A
(en)

1974-08-05
1975-08-05
Process for manufacture of 111epiiprostanic acid derivatives

DD187691A

DD124595A5
(en)

1974-08-05
1975-08-05

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

GB34334/74A

GB1486832A
(en)

1974-08-05
1974-08-05
Prostanoic acid derivatives

Publications (1)

Publication Number
Publication Date

GB1486832A
true

GB1486832A
(en)

1977-09-28

Family
ID=10364354
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB34334/74A
Expired

GB1486832A
(en)

1974-08-05
1974-08-05
Prostanoic acid derivatives

Country Status (17)

Country
Link

JP
(1)

JPS51125042A
(en)

AT
(1)

ATA606175A
(en)

AU
(1)

AU502146B2
(en)

BE
(1)

BE832098A
(en)

CA
(1)

CA1067490A
(en)

DD
(1)

DD124595A5
(en)

DE
(1)

DE2534989A1
(en)

DK
(1)

DK354575A
(en)

FI
(1)

FI752196A
(en)

FR
(1)

FR2281101A1
(en)

GB
(1)

GB1486832A
(en)

IE
(1)

IE43198B1
(en)

IN
(1)

IN141386B
(en)

NL
(1)

NL7509078A
(en)

NO
(1)

NO752734L
(en)

SE
(1)

SE7508779L
(en)

ZA
(1)

ZA754491B
(en)

Cited By (3)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

GB2197787A
(en)

*

1986-10-22
1988-06-02
Glaxo Group Ltd
Anti-inflammatory compositions

US5889052A
(en)

*

1993-08-03
1999-03-30
Alcon Laboraties, Inc.
Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension

US6184250B1
(en)

1993-08-03
2001-02-06
Alcon Laboratories, Inc.
Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension

Families Citing this family (3)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

GB1554030A
(en)

*

1976-05-10
1979-10-17
Upjohn Co
Prostaglandins

US5688819A
(en)

*

1992-09-21
1997-11-18
Allergan
Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents

US5352708A
(en)

*

1992-09-21
1994-10-04
Allergan, Inc.
Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents

1974

1974-08-05
GB
GB34334/74A
patent/GB1486832A/en
not_active
Expired

1975

1975-07-11
IE
IE1550/75A
patent/IE43198B1/en
unknown

1975-07-14
ZA
ZA00754491A
patent/ZA754491B/en
unknown

1975-07-15
CA
CA231,547A
patent/CA1067490A/en
not_active
Expired

1975-07-16
IN
IN1391/CAL/75A
patent/IN141386B/en
unknown

1975-07-16
AU
AU83102/75A
patent/AU502146B2/en
not_active
Expired

1975-07-30
NL
NL7509078A
patent/NL7509078A/en
not_active
Application Discontinuation

1975-07-31
FI
FI752196A
patent/FI752196A/fi
not_active
Application Discontinuation

1975-08-04
SE
SE7508779A
patent/SE7508779L/en
unknown

1975-08-04
BE
BE158923A
patent/BE832098A/en
unknown

1975-08-04
FR
FR7524249A
patent/FR2281101A1/en
active
Granted

1975-08-04
NO
NO752734A
patent/NO752734L/no
unknown

1975-08-05
AT
AT606175A
patent/ATA606175A/en
not_active
Application Discontinuation

1975-08-05
DK
DK354575A
patent/DK354575A/en
not_active
Application Discontinuation

1975-08-05
DD
DD187691A
patent/DD124595A5/xx
unknown

1975-08-05
JP
JP50095328A
patent/JPS51125042A/en
active
Pending

1975-08-05
DE
DE19752534989
patent/DE2534989A1/en
not_active
Withdrawn

Cited By (7)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

GB2197787A
(en)

*

1986-10-22
1988-06-02
Glaxo Group Ltd
Anti-inflammatory compositions

US4855293A
(en)

*

1986-10-22
1989-08-08
Glaxo Group Limited
Anti-inflammatory compositions comprising a systemic non-steroidal anti-inflammatory drug and a cyclopentyl ether

GB2197787B
(en)

*

1986-10-22
1990-11-21
Glaxo Group Ltd
Anti-inflammatory compositions

US5889052A
(en)

*

1993-08-03
1999-03-30
Alcon Laboraties, Inc.
Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension

US6184250B1
(en)

1993-08-03
2001-02-06
Alcon Laboratories, Inc.
Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension

US6344478B2
(en)

1993-08-03
2002-02-05
Alcon Manufacturing, Ltd.
Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension

US6723748B2
(en)

1993-08-03
2004-04-20
Alcon Manufacturing, Ltd.
Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension

Also Published As

Publication number
Publication date

ATA606175A
(en)

1978-05-15

FR2281101A1
(en)

1976-03-05

ZA754491B
(en)

1976-06-30

SE7508779L
(en)

1976-02-06

DK354575A
(en)

1976-02-06

NL7509078A
(en)

1976-02-09

IE43198B1
(en)

1981-01-14

IN141386B
(en)

1977-02-19

AU502146B2
(en)

1979-07-12

CA1067490A
(en)

1979-12-04

DE2534989A1
(en)

1976-02-26

BE832098A
(en)

1976-02-04

JPS51125042A
(en)

1976-11-01

FR2281101B1
(en)

1978-11-10

DD124595A5
(en)

1977-03-02

FI752196A
(en)

1976-02-06

AU8310275A
(en)

1977-01-20

IE43198L
(en)

1976-02-05

NO752734L
(en)

1976-02-06

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Legal Events

Date
Code
Title
Description

1978-02-08
PS
Patent sealed [section 19, patents act 1949]

1986-03-05
PCNP
Patent ceased through non-payment of renewal fee

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