GB1503116A – Sustained release drug delivery devices
– Google Patents
GB1503116A – Sustained release drug delivery devices
– Google Patents
Sustained release drug delivery devices
Info
Publication number
GB1503116A
GB1503116A
GB2809376A
GB2809376A
GB1503116A
GB 1503116 A
GB1503116 A
GB 1503116A
GB 2809376 A
GB2809376 A
GB 2809376A
GB 2809376 A
GB2809376 A
GB 2809376A
GB 1503116 A
GB1503116 A
GB 1503116A
Authority
GB
United Kingdom
Prior art keywords
pharmaceutical
polymer
environment
release
soluble substance
Prior art date
1975-07-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2809376A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1975-07-28
Filing date
1976-07-06
Publication date
1978-03-08
1976-07-06
Application filed by Alza Corp
filed
Critical
Alza Corp
1978-03-08
Publication of GB1503116A
publication
Critical
patent/GB1503116A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K9/00—Medicinal preparations characterised by special physical form
A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
Abstract
The device for delayed pharmaceutical release is used in an aqueous environment in the human or animal body. It essentially releases the pharmaceutical by diffusion. It displays an integral solid structure of such a shape and size that it can be introduced into the environment in which it is to be used and can be held there. It consists of a mixture which contains a non-ionic pharmaceutical, a polymer and, in addition, 0.1 to 15% by weight of a soluble substance with osmotic activity. The pharmaceutical has a solubility in water of from 200 to 10,000 ppm. The polymer is permeable to water and to the pharmaceutical, is insoluble in the aqueous environment at least for the duration of the pharmaceutical release and is impermeable to the soluble substance. The soluble substance is in the form of single depots which have a number average diameter of 1 to 250 mu m which are dispersed in the polymer so that they are surrounded essentially singly by a polymer layer. When the device is introduced into the aqueous environment, the depots absorb water and rupture the surrounding polymer layers. This results in a network of mutually connected pores inside the device. There is thus an in situ enlargement of the surface area on which the pharmaceutical can be released from the polymer to the environment. This in situ enlargement of the surface area increases the rate of release of the pharmaceutical from the device.
GB2809376A
1975-07-28
1976-07-06
Sustained release drug delivery devices
Expired
GB1503116A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
US59979575A
1975-07-28
1975-07-28
Publications (1)
Publication Number
Publication Date
GB1503116A
true
GB1503116A
(en)
1978-03-08
Family
ID=24401120
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB2809376A
Expired
GB1503116A
(en)
1975-07-28
1976-07-06
Sustained release drug delivery devices
Country Status (8)
Country
Link
JP
(1)
JPS5215810A
(en)
CA
(1)
CA1083041A
(en)
CH
(1)
CH623232A5
(en)
DE
(1)
DE2633987A1
(en)
FR
(1)
FR2319380A1
(en)
GB
(1)
GB1503116A
(en)
IT
(1)
IT1069521B
(en)
SE
(1)
SE7608161L
(en)
Cited By (3)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
EP0080330A2
(en)
*
1981-11-18
1983-06-01
Stc Plc
Composite materials
WO1997037640A2
(en)
*
1996-04-05
1997-10-16
Alza Corporation
Uniform drug delivery therapy
US6096339A
(en)
*
1997-04-04
2000-08-01
Alza Corporation
Dosage form, process of making and using same
Families Citing this family (3)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
GB2048710B
(en)
*
1979-05-07
1983-03-09
Alza Corp
Osmotically driven fluid dispenser
JPS60139222U
(en)
*
1984-02-28
1985-09-14
株式会社東芝
foldable recorder
DE19537090A1
(en)
*
1995-10-05
1997-04-10
Lohmann Therapie Syst Lts
Osmotic device for the continuous release of active substances into the fluids of the gastrointestinal tract
Family Cites Families (2)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US3892842A
(en)
*
1971-09-01
1975-07-01
Alza Corp
Intrauterine contraceptive device for releasing steroid having double bond functionality
GB1425550A
(en)
*
1973-04-25
1976-02-18
Alza Corp
Device for releasing active agent and process for producing the same
1976
1976-07-06
GB
GB2809376A
patent/GB1503116A/en
not_active
Expired
1976-07-16
SE
SE7608161A
patent/SE7608161L/en
not_active
Application Discontinuation
1976-07-20
CA
CA257,322A
patent/CA1083041A/en
not_active
Expired
1976-07-27
FR
FR7622829A
patent/FR2319380A1/en
active
Granted
1976-07-27
IT
IT6887676A
patent/IT1069521B/en
active
1976-07-27
JP
JP8960076A
patent/JPS5215810A/en
active
Pending
1976-07-28
DE
DE19762633987
patent/DE2633987A1/en
not_active
Withdrawn
1976-07-28
CH
CH967576A
patent/CH623232A5/en
not_active
IP Right Cessation
Cited By (5)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
EP0080330A2
(en)
*
1981-11-18
1983-06-01
Stc Plc
Composite materials
EP0080330A3
(en)
*
1981-11-18
1983-07-13
Standard Telephones And Cables Public Limited Company
Composite materials
WO1997037640A2
(en)
*
1996-04-05
1997-10-16
Alza Corporation
Uniform drug delivery therapy
WO1997037640A3
(en)
*
1996-04-05
1997-11-13
Alza Corp
Uniform drug delivery therapy
US6096339A
(en)
*
1997-04-04
2000-08-01
Alza Corporation
Dosage form, process of making and using same
Also Published As
Publication number
Publication date
FR2319380A1
(en)
1977-02-25
DE2633987A1
(en)
1977-02-10
FR2319380B1
(en)
1978-11-17
CH623232A5
(en)
1981-05-29
SE7608161L
(en)
1977-01-29
JPS5215810A
(en)
1977-02-05
CA1083041A
(en)
1980-08-05
IT1069521B
(en)
1985-03-25
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Legal Events
Date
Code
Title
Description
1978-07-19
PS
Patent sealed
1983-02-09
PCNP
Patent ceased through non-payment of renewal fee
