GB1503479A – Trazino benzodiazepines
– Google Patents
GB1503479A – Trazino benzodiazepines
– Google Patents
Trazino benzodiazepines
Info
Publication number
GB1503479A
GB1503479A
GB1409/77A
GB140977A
GB1503479A
GB 1503479 A
GB1503479 A
GB 1503479A
GB 1409/77 A
GB1409/77 A
GB 1409/77A
GB 140977 A
GB140977 A
GB 140977A
GB 1503479 A
GB1503479 A
GB 1503479A
Authority
GB
United Kingdom
Prior art keywords
triazinobenzodiazepines
benzodiazepin
dihydro
chloro
alkyl
Prior art date
1976-02-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1409/77A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1976-02-09
Filing date
1977-01-13
Publication date
1978-03-08
1977-01-13
Application filed by Upjohn Co
filed
Critical
Upjohn Co
1978-03-08
Publication of GB1503479A
publication
Critical
patent/GB1503479A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 – C07D477/00
C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 – C07D477/00 in which the condensed system contains two hetero rings
C07D487/04—Ortho-condensed systems
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P21/00—Drugs for disorders of the muscular or neuromuscular system
A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/00—Drugs for disorders of the nervous system
A61P25/20—Hypnotics; Sedatives
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
C07D243/20—Nitrogen atoms
Abstract
1503479 Triazinobenzodiazepines UPJOHN CO 13 Jan 1977 [9 Feb 1976] 01409/77 Heading C2C Triazinobenzodiazepines and their acid addition salts are prepared by the following route (R, R 1 =H, C 1-3 alkyl; R 2 =H, Me; R 3 =H, F, Cl, Br, CF 3 , NO 2 ; Ar=2-Py, Ph, o-chloro or fluorophenyl, 2,6-difluorophenyl; Y = Cl, Br, I, OSO 2 R 4 ; R 4 = C 1-3 alkyl, Ph, tolyl) or cyclizing a corresponding (1,3-dihydro-1-(2,2-dialkoxyethyl) – 5 – aryl – 2H – 1,4 – benzodiazepin – 2- yl)hydrazine with sulphuric acid. The preparation of 7-chloro-1,3-dihydro-1-(2,2- dimethoxyethyl) – 5 – phenyl – 2H – 1,4 – benzodiazepin-2-one is described. The above compounds are sedatives, hypnotics, anticonvulsants, tranquillizers and muscle relaxants, and increase growth rate and feed efficiency of livestock. They may be administered in the form of pharmaceutical and veterinary preparations containing them in association with a carrier.
GB1409/77A
1976-02-09
1977-01-13
Trazino benzodiazepines
Expired
GB1503479A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
US05/656,371
US4016165A
(en)
1976-02-09
1976-02-09
Triazino benzodiazepines
Publications (1)
Publication Number
Publication Date
GB1503479A
true
GB1503479A
(en)
1978-03-08
Family
ID=24632739
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB1409/77A
Expired
GB1503479A
(en)
1976-02-09
1977-01-13
Trazino benzodiazepines
Country Status (5)
Country
Link
US
(1)
US4016165A
(en)
JP
(1)
JPS5297998A
(en)
DE
(1)
DE2700539A1
(en)
FR
(1)
FR2340319A1
(en)
GB
(1)
GB1503479A
(en)
Families Citing this family (3)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US4086230A
(en)
*
1977-03-09
1978-04-25
The Upjohn Company
1,5-Dihydro-7-aryl-as-triazine[4,3,-α][1,4]benzodiazepin-1-ols
US4073784A
(en)
*
1977-03-09
1978-02-14
The Upjohn Company
Certain as-triazino 4,3-a! 1,4!benzodiazepine-1,2-dione compounds
US4073785A
(en)
*
1977-03-09
1978-02-14
The Upjohn Company
Certain as-triazino 4,3-a! 1,4!benzodiazepine derivatives
Family Cites Families (2)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
BE793629A
(en)
*
1972-01-03
1973-07-03
Upjohn Co
NEW BENZODIAZEPINE DERIVATIVES AND THEIR PREPARATION
US3933816A
(en)
*
1974-09-12
1976-01-20
The Upjohn Company
3-(Substituted aminomethyl)-7-substituted-3,5-dihydro-as-triazino[4,3-a][1,5]benzodiazepines
1976
1976-02-09
US
US05/656,371
patent/US4016165A/en
not_active
Expired – Lifetime
1977
1977-01-07
DE
DE19772700539
patent/DE2700539A1/en
not_active
Withdrawn
1977-01-13
GB
GB1409/77A
patent/GB1503479A/en
not_active
Expired
1977-02-08
FR
FR7703489A
patent/FR2340319A1/en
active
Granted
1977-02-09
JP
JP1349777A
patent/JPS5297998A/en
active
Granted
Also Published As
Publication number
Publication date
US4016165A
(en)
1977-04-05
DE2700539A1
(en)
1977-08-11
FR2340319A1
(en)
1977-09-02
FR2340319B1
(en)
1980-02-08
JPS6228145B2
(en)
1987-06-18
JPS5297998A
(en)
1977-08-17
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Legal Events
Date
Code
Title
Description
1978-07-19
PS
Patent sealed [section 19, patents act 1949]
1987-09-03
PCNP
Patent ceased through non-payment of renewal fee
