GB1506309A - Creation of Inventions and Patents with Artificial Intelligence

GB1506309A – 2-substituted-9-phenyl-2,3,4,4a,9,9a-hexahydro-1h-indeno(2,1-c)pyridines and related compounds
– Google Patents

GB1506309A – 2-substituted-9-phenyl-2,3,4,4a,9,9a-hexahydro-1h-indeno(2,1-c)pyridines and related compounds
– Google Patents
2-substituted-9-phenyl-2,3,4,4a,9,9a-hexahydro-1h-indeno(2,1-c)pyridines and related compounds

Info

Publication number
GB1506309A

GB1506309A
GB24981/76A
GB2498176A
GB1506309A
GB 1506309 A
GB1506309 A
GB 1506309A
GB 24981/76 A
GB24981/76 A
GB 24981/76A
GB 2498176 A
GB2498176 A
GB 2498176A
GB 1506309 A
GB1506309 A
GB 1506309A
Authority
GB
United Kingdom
Prior art keywords
compounds
indeno
alk
cis
june
Prior art date
1975-06-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB24981/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

GD Searle LLC

Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1975-06-16
Filing date
1976-06-16
Publication date
1978-04-05

1976-06-16
Application filed by GD Searle LLC
filed
Critical
GD Searle LLC

1978-04-05
Publication of GB1506309A
publication
Critical
patent/GB1506309A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings

C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom

C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members

C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

C07D211/40—Oxygen atoms

C07D211/44—Oxygen atoms attached in position 4

C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P9/00—Drugs for disorders of the cardiovascular system

A61P9/08—Vasodilators for multiple indications

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P9/00—Drugs for disorders of the cardiovascular system

A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 – C07D219/00

C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 – C07D219/00 condensed with carbocyclic rings or ring systems

C07D221/04—Ortho- or peri-condensed ring systems

C07D221/06—Ring systems of three rings

C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered

Abstract

1506309 Indeno[2,1-c]pyridenes G D SEARLE & CO 16 June 1976 [16 June 1975] 24981/76 Heading C2C The invention comprises compounds of formula and their pharmaceutically acceptable acid addition and quaternary ammonium salts, wherein Alk is C 2-6 alkylene of which at least 2C separate the N atoms; NRR1 is di(C 1-6 alkyl)amino, pyrrolidino, piperidono or hexamethyleneimino; and the dotted lines indicate the optional simultaneous presence of these two double bonds. In Examples, the dihydro compounds (A) prepared by cyclizing with HBr 1 – aminoalkyl – 3 – benzoyl – 4 – phenylpiperidin – 4 – ols (B), are reduced with H 2 /Pd to the cis-phenyl hexahydro compounds, and the latter are converted to the transisomers by heating with KOH/BuOH; alternatively, the cis- and trans-isomers may each be obtained by reacting the respective-ring-N- unsubstituted analogues [obtained by corresponding synthetic route from (B), 1-benzyl analogue and (A), ring-N-benzyl analogue] with RR1N-Alk-halide. Therapeutic compositions having antiarrhythmic and antibacterial activity, as well as disinfectant compositions, comprise compounds of the above formula. The usual modes of administration and application are mentioned.

GB24981/76A
1975-06-16
1976-06-16
2-substituted-9-phenyl-2,3,4,4a,9,9a-hexahydro-1h-indeno(2,1-c)pyridines and related compounds

Expired

GB1506309A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

US05/587,405

US3981875A
(en)

1975-06-16
1975-06-16
2-Substituted-9-phenyl-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-c]pyridines and related compounds

Publications (1)

Publication Number
Publication Date

GB1506309A
true

GB1506309A
(en)

1978-04-05

Family
ID=24349661
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB24981/76A
Expired

GB1506309A
(en)

1975-06-16
1976-06-16
2-substituted-9-phenyl-2,3,4,4a,9,9a-hexahydro-1h-indeno(2,1-c)pyridines and related compounds

Country Status (7)

Country
Link

US
(1)

US3981875A
(en)

JP
(1)

JPS52276A
(en)

CA
(1)

CA1070686A
(en)

DE
(1)

DE2626677A1
(en)

FR
(1)

FR2314716A1
(en)

GB
(1)

GB1506309A
(en)

NL
(1)

NL7606454A
(en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

GB8503749D0
(en)

1985-02-14
1985-03-20
Craig Med Prod Ltd
Gas filter

US4753573A
(en)

1987-03-23
1988-06-28
Mcknight Charles A
Filtering means for ceiling fan blades

Family Cites Families (4)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US2470109A
(en)

1949-05-17

Heterocyclic amines

FR1018758A
(en)

1947-01-11
1953-01-13
Hoffmann La Roche

Process for the preparation of heterocyclic amines

US2546652A
(en)

1949-07-30
1951-03-27
Hoffmann La Roche
Pyridindenes and process for their manufacture

GB1175676A
(en)

1966-02-04
1969-12-23
Prizer Ltd
Indeno-Pyridine Derivatives

1975

1975-06-16
US
US05/587,405
patent/US3981875A/en
not_active
Expired – Lifetime

1976

1976-06-15
NL
NL7606454A
patent/NL7606454A/en
not_active
Application Discontinuation

1976-06-15
CA
CA254,837A
patent/CA1070686A/en
not_active
Expired

1976-06-15
FR
FR7618136A
patent/FR2314716A1/en
active
Granted

1976-06-15
JP
JP51070334A
patent/JPS52276A/en
active
Pending

1976-06-15
DE
DE19762626677
patent/DE2626677A1/en
not_active
Withdrawn

1976-06-16
GB
GB24981/76A
patent/GB1506309A/en
not_active
Expired

Also Published As

Publication number
Publication date

JPS52276A
(en)

1977-01-05

FR2314716B1
(en)

1978-10-20

US3981875A
(en)

1976-09-21

CA1070686A
(en)

1980-01-29

FR2314716A1
(en)

1977-01-14

DE2626677A1
(en)

1977-01-20

NL7606454A
(en)

1976-12-20

Información de contacto