GB1565767A – Substituted 1,2,4 – triazines processes for their preparation and pharmaceutical compositions containing them
– Google Patents
GB1565767A – Substituted 1,2,4 – triazines processes for their preparation and pharmaceutical compositions containing them
– Google Patents
Substituted 1,2,4 – triazines processes for their preparation and pharmaceutical compositions containing them
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Publication number
GB1565767A
GB1565767A
GB9393/78A
GB939378A
GB1565767A
GB 1565767 A
GB1565767 A
GB 1565767A
GB 9393/78 A
GB9393/78 A
GB 9393/78A
GB 939378 A
GB939378 A
GB 939378A
GB 1565767 A
GB1565767 A
GB 1565767A
Authority
GB
United Kingdom
Prior art keywords
oxo
triazine
dimethylaminophenyl
formula
methyl
Prior art date
1977-03-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB9393/78A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre SA
Original Assignee
Pierre Fabre SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1977-03-09
Filing date
1978-03-09
Publication date
1980-04-23
1977-03-09
Priority claimed from FR7707245A
external-priority
patent/FR2383176A1/en
1978-02-17
Priority claimed from FR7804822A
external-priority
patent/FR2417508A2/en
1978-03-09
Application filed by Pierre Fabre SA
filed
Critical
Pierre Fabre SA
1980-04-23
Publication of GB1565767A
publication
Critical
patent/GB1565767A/en
Status
Expired
legal-status
Critical
Current
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Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
C07D253/06—1,2,4-Triazines
C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
C07D253/06—1,2,4-Triazines
C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Description
PATENT SPECIFICATION ( 11) 1565 767
( 21) Application No 9393/78 ( 22) Filed 9 March 1978 ( 31) Convention Application No7 707 245 ( 19) Em ( 32) Filed 9 March 1977 e ( 31) Convention Application No 7 804 822 ( 32) Filed 17 Feb 1978 in ( 33) France (FR) ( 44) Complete Specification published 23 April 1980 ( 51) INT CL 3 C 07 D 253/06; A 61 K 31/535; C 07 D 413/06; (C 07 D 413/06, 253/06, 295/12) ( 52) Index at acceptance C 2 C 1562 1651 200 215 220 22 Y 246 250 252 255 25 Y 28 X 305 30 Y 313 31 Y 323 328 32 Y 338 351 352 372 620 625 630 640 650 660 680 699 758 761 768 802 80 Y AA LK RM A 5 B 180 190 20 X 20 Y 327 32 Y 361 36 Y 381 382 38 Y 392 413 41 Y 466 46 Y 471 47 Y 480 482 48 Y 491 49 Y 503 504 50 Y 542 544 54 Y 566 56 Y 586 58 Y 650 65 Y 671 H ( 54) SUBSTITUTED 1,2,4-TRIAZINES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM ( 71) We, PIERRE FABRE SA, a French Societe Anonyme, of 125 Rue de la Faisanderie, Paris 16, France, do hereby declare the invention for which we pray that a patent may be granted to us, and the method by which it is to be performed,
to be particularly described in and by the following statement:-
This invention relates to substituted 1,2,4-triazines, to processes for their 5 preparation, and to pharmaceutical compositions containing them.
5,6-Diaryl-l,2,4-triazines have been described by John G Erikson in ” 1,2, 3and 1,2,4-triazines, tetrazines and pentazines” (The Chemistry of Heterocyclic Compound, Vol 10, pp 44-84, Interscience Publishers, New York, 1956).
More recent publications (U S Patent No 3,948,894 and Belgian Patent No 10 839,469) describe compounds which are generally similar to those of the present invention but differ by the absence of a 2-substituent which endows the compounds with valuable pharmacological properties.
The present invention provides compounds of the general formula I? isH R R/
