GB1574684A – M-bromo-benzotrifluorides
– Google Patents
GB1574684A – M-bromo-benzotrifluorides
– Google Patents
M-bromo-benzotrifluorides
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Publication number
GB1574684A
GB1574684A
GB6645/78A
GB664578A
GB1574684A
GB 1574684 A
GB1574684 A
GB 1574684A
GB 6645/78 A
GB6645/78 A
GB 6645/78A
GB 664578 A
GB664578 A
GB 664578A
GB 1574684 A
GB1574684 A
GB 1574684A
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GB
United Kingdom
Prior art keywords
process according
bromination
effected
bromo
catalyst
Prior art date
1977-02-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB6645/78A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1977-02-25
Filing date
1978-02-20
Publication date
1980-09-10
1978-02-20
Application filed by Bayer AG
filed
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Bayer AG
1980-09-10
Publication of GB1574684A
publication
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patent/GB1574684A/en
Status
Expired
legal-status
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Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
C07C25/02—Monocyclic aromatic halogenated hydrocarbons
C07C25/13—Monocyclic aromatic halogenated hydrocarbons containing fluorine
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C17/00—Preparation of halogenated hydrocarbons
C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
C07C17/12—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the ring of aromatic compounds
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C17/00—Preparation of halogenated hydrocarbons
C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
C07C17/20—Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms
C07C17/202—Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms two or more compounds being involved in the reaction
C07C17/206—Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms two or more compounds being involved in the reaction the other compound being HX
Description
PATENT SPECIFICATION ( 11) 1 574 684
E ( 21) Application No 6645/78 ( 22) Filed 20 Feb 1978 ( 31) Convention Application No 2708190 ( 32) Filed 25 Feb1977 in 1 K ( 33) Federal Republic of Germany (DE) ( 44) Complete Specification published 10 Sept 1980 ( 51) INT CL 3 C 07 C 21/00 17/20 ( 52) Index at acceptance C 2 C 220 227 22 Y 311 313 314 31 Y 338 440 441 442 443 444 445 564 565 694 73 Y 776 AB HK ( 72) Inventors ALBRECHT MARHOLD and ERICH KLAUKE ( 54) m-B ROMO-BENZOTRIFLUORIDES ( 71) We, BAYER AKTIENGESELLSCHAFT, a body corporate, organised under the laws of Germany, of Leverkusen, Federal Republic of Germany, do hereby declare the invention, for which we pray that a patent may be granted to us, and the method by which it is to be performed to be particularly described in and by the following statement: 5
The invention relates to a process for the preparation of m bromo benzotrifluorides.
It is known to prepare 3 bromo 4 chloro benzotrifluoride by brominating 4 chloro benzotrifluoride, using iron as a catalyst (J Am Chem.
Soc 71, 2659 ( 1949)) The yield of the process is about 55 %; a large proportion of 10 the 4-chlorobenzotrifluoride employed is saponified to the corresponding carboxylic acid during the process The 4 chlorobenzotrifluoride must in turn be prepared by fluorinating 4 chlorobenzotrichloride.
It is also known to carry out the bromination of trifluoromethylbenzenes in the presence of antimony pentachloride as a catalyst (J Am Chem Soc 72, 1651 15 ( 1950)) In this reaction, the yield is only about 30 to 35 %.
A process has been found for the preparation of m bromobenzotrifluorides, in which a benzotrichloride of the formula c Ct 3 (I) X wherein 20 X denotes hydrogen, halogen or a C,-C 4 alkyl radical, is first brominated in the presence of a catalyst, and the product is then reacted with hydrofluoric acid at elevated temperature and under elevated pressure.
The process according to the invention is illustrated with the aid of the following equation for the preparation of 3 bromo 4 chloto 25 benzotrifluorode; CCL 3 CCL 3 CF 3 ó$ ó) HF 8 r Sr CI Ct Ca Halogens (X) for the process according to the invention can be fluoride, chlorine, bromine or iodine, preferably fluorine or chlorine.
An alkyl radical (X) can be a straight-chain or branched aliphatic hydrocarbon 30 radical with 1 to 4 carbon atoms In detail, there may be mentioned methyl, ethyl, propyl, isopropyl, butyl and isobutyl, preferably methyl and ethyl.
2 1,574,684 2 Friedel-Crafts catalysts may be mentioned as catalysts for the bromination All the catalysts customary for Friedel-Crafts reactions can be used as the FriedelCrafts catalysts Examples which may be mentioned are iron powder, iron sulphide, iron chloride, iron bromide, aluminium bromide and aluminium chloride, preferably iron sulphide and iron 5 The amount of catalyst can vary from 0 2 to 1 /, by weight, preferably 0 3 to 0.5 % by weight, relative to the benzotrichloride The bromination step of the process according to the invention can be carried out in the temperature range from 0 to 1000 C, preferably 20 to 700 C, and particularly preferably from 30 to 600 C 10 The bromination step can be carried out under normal pressure or under excess pressure In general, the bromination step is carried out under normal pressure In order to prevent the bromine from distilling off, it can be advantageous to carry out the process under elevated pressure.
The process according to the invention is preferably carried out without a 15 solvent or diluent However, it is also possible to carry out the process in solvents or diluents which are inert under the reaction conditions Examples of these which may be mentioned are: chlorinated hydrocarbons, such as chloroform, carbon tetrachloride and tetrachloroethylene.
In general, the flurorination step of the process according to the invention is 20 carried out in the temperature range of about -10 to 1200 C, preferably of 60 to 1000 C A lower temperature is employed when using an additional fluorinating catalyst, for example antimony pentachloride, an elevated temperature is employed when using anhydrous hydrofluoric acid only.
The fluorination step of the process according to the invention is carried out 25 under elevated pressure In general, the fluorination step is carried out in the pressure range of 3 to 40 bars, preferably of 6 to 10 bars.
Antimony trifluoride and, in particular, anhydrous hydrofluoric acid, have proved to be suitable fluorinating agents.
The process according to the invention is generally carried out as a “onepot 30 process”, that is to say without isolating the bromination product obtained during the bromination The bromination product predominantly consists of optionally substituted m bromo benzotrichloride, which is a new chemical compound.
However, it is, of course, also possible to isolate the bromination product.
The process according to the invention can be carried out as follows: 35 The benzotrichloride and the catalyst are initially introduced into the reaction vessel, appropriately an autoclave, and the bromine is added dropwise at the chosen reaction temperature After the bromination has ended, an inert gas, for example nitrogen, is passed through the reaction mixture in order to expel excess bromine 40 The reaction mixture is then cooled, the hydrofluoric acid is added and excess pressure is established in the autoclave with the aid of the inert gas It is warmed up to the reaction temperature of the fluorination stage The hydrogen chloride gas formed is let down via a regulating valve, with the aid of which the reaction pressure can be adjusted 45 After the reaction has ended, the reaction mixture is let down and is worked up in the customary manner by steam distillation or fractional distillation.
Compared with the known processes for the preparation of m bromo benzotrifluorides, the process according to the invention has the considerable advantages that it gives a substantially improved yield, that is to say 70-84 /, of 50 theory instead of the 30-50 % achieved hitherto, and that m bromo benzotrifluorides which have not yet hitherto been obtained, for example 4 fluoro 3 bromo benzotrifluoride and 4 methyl 3 bromo benzotrifluoride, can be prepared using it.
Compounds of the formula 55 CF 3 wherein X denotes hydrogen, halogen or a C,-C 4 alkyl radical, are formed by the process according to the invention.
The m bromo benzotrifluorides can be reacted with copper cyanide to give the corresponding 3 trifluoromethylbenzonitriles (literature: U S Patent Specification 2,195,076), which are agents for combating parasites (DT-OS (German Published Specification) 2,344,603) Moreover, the 3 trifluoromethyl benzonitriles are important intermediate products for plant protection agents and 5 pharmaceuticals (DT-AS (German Published Specification) 1,286,871 and U S.
Patent Specification 3,133,081).
Example 1
920 g of 4 chlorobenzotrichloride are initially introduced into an autoclave, 4 g of iron sulphide are added and 690 g of bromine are added dropwise at 50 C in 10 the source of 4 hours The mixture is then subsequently stirred for 4 hours at 60 C, excess bromine is expelled with nitrogen and the mixture is cooled to -10 C I kg of anhydrous hydrofluoric acid is added to the reaction mixture obtained, the autoclave is closed and the pressure is increased to 2 bars of nitrogen The mixture is then warmed to 60 C and the hydrogen chloride formed is let down via a reflux 15 condenser with a regulating valve at about 7 bars After 30 minutes; the mixture is heated to 80 to 85 C for 6 hours and, after the evolution of gas has ended, is cooled and excess hydrofluoric acid is distilled off The residue is fractionated in vacuo.
This gives a fore-run of 60 g (boiling point 1:30 to 75 C), which consists predominantly of 4 chlorobenzotrifluoride, and then a main run (boiling 20 point 15:78 to 81 C) of 790 g of 4 chloro 3 bromo benzotrifluoride, which corresponds to a yield of 75 % of theory, relative to the 4 chlorobenzotrifluoride employed.
Example 2
920 g of 4 chlorobenzotrichloride and 3 g of iron powder are initially 25 introduced, at 30 C, into a reaction vessel, 690 g of bromine are added dropwise in the course of 1 hour and the mixture is subsequently stirred for 6 hours at 30 C.
The crude bromination product is freed from excess bromine at 40 C and under a pressure of I mm in a thin film evaporator The crude product is added, at 10 C, to 800 ml of anhydrous hydrofluoric acid, the autoclave is closed and fluorination is 30 carried out under a pressure of 3 bars as in Example 1.
Fractional distillation gives 840 g of 4 chloro 3 bromo benzotrifluoride as the main fraction at boiling point 15:77 to 81 C, which corresponds to a yield of 81 % of theory.
Example 3 35
690 g of bromine are added dropwise, at 30 C, to 920 g of 2 chlorobenzotrichloride and 3 g of iron sulphide in the course of I hour The mixture is then subsequently stirred for 6 hours at 30 C, excess bromine is separated off in a thin film evaporator and the reaction product is added to 800 g of anhydrous hydrofluoric acid in an autoclave The pressure is increased to 3 bars of nitrogen 40 and the mixture is heated to 70 C, the hydrochloric acid formed being removed at bars After 2 hours the reaction mixture is heated to ‘100 C and kept at this temperature until the evolution of gas has ceased After cooling, excess hydrofluoric acid is distilled off After steam distillation, 2 5 1 of a distillate are obtained, the organic phase of which is separated off; the organic phase is dried 45 with sodium bisulphate.
The 900 g of crude product consist of: 1 7 % of 2,5 dichlorobenzotrifluoride, 92.3 % of 2 chloro 5 bromo benzotrifluoride, 4 4 % of 2 chloro 3 bromo benzotrifluoride and 3 % of a dibromo compound The yield of chloro bromo benzotrifluorides is accordingly 84 % of theory 50 Pure 2 chloro 5 bromo benzotrifluoride is obtained by distillation, boiling point: 198 to 199 C; N 20: 1 5040.
Example 4
585 g of benzotrichloride are initially introduced into the reaction vessel at 50 C with 2 g of iron powder, 480 g of bromine are added dropwise in the course of 55 I hour, the mixture is stirred for 4 hours at 50 C, the bromine is expelled by passing nitrogen through and the catalyst is then filtered off.
600 ml of anhydrous hydrofluoric acid are initially introduced into an apparatus for the fluorination reaction, the crude bromination product is added dropwise at -4 C and the temperature is raised to 20 C until the hydrogen chloride 60 evolution has ended The pressure is then increased with nitrogen, the mixture is warmed to 70 C for 3 hours and cooled and excess hydrofluoric acid, is distilled 1,574,684 off The organic residue is washed with 100 ml of 40 % strength sodium bisulphide solution and then with 100 ml of water and the organic phase, which has been separated off, is dried with calcium chloride and subjected to fractional distillation.
After a fore-run of 50 g of benzotrifluoride 411 g ( 61 % of theory) of 3 bromo benzotrifluoride are obtained with a boiling point: 154 to 155 C 5 Example 5 g of bromine are added dropwise, at 50 to 55 C, to-157 g of 4 fluorobenzotrichloride and I g of iron sulphide in the course of 1 hour, the mixture is then subsequently stirred at 55 C for 5 hours, and finally excess bromine is expelled with nitrogen 10 The reaction mixture is then added dropwise to 160 ml of anhydrous hydrofluoric acid at O C in a fluorinating apparatus, the mixture is warmed to C, whilst stirring, the pressure is increased with nitrogen, the mixture is warmed to 70 C for 7 hours and the hydrogen chloride evolved is separated off at 7 5 bars.
After cooling to room temperature, excess hydrofluoric acid is distilled off and the 15 residue is subjected to fractional distillation under 35 mm After a forerun of 10 g (boiling point 35: 32 to 40 C), 94 g ( 52 % of theory) of 4 fluoro 3 bromo benzotrifluoride pass over at boiling point 35: 53 to 60 C.
Example 6
0 5 g or iron sulphide is added to 240 g of 4 methyl benzotrichloride and 20 g of bromine are added dropwise at 30 C The mixture is stirred for 6 hours at C and excess bromine is then separated off by passing nitrogen through.
g of anhydrous hydrofluoric acid are initially introduced, at -10 C, into a fluorinating apparatus and the crude bromination product is then added dropwise.
Thereafter, the hydrogen chloride evolution is allowed to subside in the course of 25 about 3 hours at 18 C, the pressure is increased to 5 bars of nitrogen and the mixture is warmed to 70 C, the hydrogen chloride being separated off at about 8 5 bars After about 2 hours, the mixture is cooled, excess hydrofluoric acid is distilled off and the crude product is subjected to fractional distillation After a fore-run of 4 methyl benzotrifluoride, 146 g (corresponding to 61 % of theory) of 3 30 bromo 4 methyl benzotrifluoride are obtained at boiling point 4: 62 to 68 C.
Claims (13)
WHAT WE CLAIM IS:-
1 A process for the preparation of a m bromo benzotrifluoride of the general formula (II) x Er in which X is hydrogen, halogen or C 1-C 4 alkyl, in which a benzotrichloride of the general formula X (I) in which 40 X has the meaning stated above, is first brominated in the presence of a catalyst and the bromination product is then reacted with a fluorinating agent at elevated temperature and under elevated pressure.
2 A process according to Claim 1, in which the bromination is effected in the 45 presence of a Friedel-Crafts catalyst.
3 A process according to Claim 2, in which the bromination catalyst is iron sulphide or iron 1.574684
4 A process according to Claim 1, 2 or 3 in which the bromination catalyst is present in an amount of from 0 2 to 1 / by weight.
A process according to Claim 4, in which the bromination catalyst is present in an amount of from 0 3 to 0
5 , by weight.
6 A process according to any of Claims 1 to 5, in which the bromination is 5 effected at from O to 100 C.
7 A process according to Claim 6, in which the bromination is effected at from to 70 C.
8 A process according to Claim 7, in which the bromination is effected at from 30 to 60 C 10
9 A process according to any of Claims I to 8, in which the fluorination is effected at from –
10 C to 120 C.
A process according to Claim 9, in which the fluorination is effected at from 60 C to 100 C with anhydrous hydrofluoric acid.
11 A process according to any of claims I to 10, in which the fluorination is 15 effected under a pressure of from 3 to 40 bars.
12 A process according to Claim 11, in which the fluorination is effected under a pressure of from 6 to 10 bars.
13 A process for the preparation of a m bromo benzotrifluoride, being a process substantially as described in any one of Examples I to 6 20 14 An optionally substituted m bromo benzotrifluoride whenever prepared by a process accroding to any of Claims I to 13.
An optionally substituted m bromo benzotrichloride whenever prepared by a process according to any of Claims 1 to 8.
For the Applicants, CARPMAELS & RANSFORD, Chartered Patent Agents, 43 Bloomsbury Square, London, W C I.
Printed for Her Majesty’s Stationery Office, by the Courier Press Leamineton Spa 1980 Published by The Patent Office, 25 Southampton Buildings London WCA l AY from which copies may be obtained.
1,574684 1
GB6645/78A
1977-02-25
1978-02-20
M-bromo-benzotrifluorides
Expired
GB1574684A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
DE2708190A
DE2708190C2
(en)
1977-02-25
1977-02-25
Process for the preparation of m-bromo-benzotrifluorides
Publications (1)
Publication Number
Publication Date
GB1574684A
true
GB1574684A
(en)
1980-09-10
Family
ID=6002158
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB6645/78A
Expired
GB1574684A
(en)
1977-02-25
1978-02-20
M-bromo-benzotrifluorides
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US
(1)
US4155940A
(en)
JP
(1)
JPS53105435A
(en)
BE
(1)
BE864280A
(en)
CH
(1)
CH633244A5
(en)
DE
(1)
DE2708190C2
(en)
FR
(1)
FR2381733A1
(en)
GB
(1)
GB1574684A
(en)
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
EP0216541A1
(en)
*
1985-09-19
1987-04-01
Imperial Chemical Industries Plc
Aryl pyridones
Families Citing this family (9)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US4393257A
(en)
*
1976-12-27
1983-07-12
Daikin Kogyo Co., Ltd.
Process for preparing benzotrifluoride and its derivatives
DE2837499A1
(en)
*
1978-08-28
1980-03-20
Bayer Ag
METHOD FOR PRODUCING SUBSTITUTED BENZOTRIFLUORIDES AND NEW SUBSTITUTED BENZOTRIFLUORIDES
DE2928987A1
(en)
*
1979-07-18
1981-02-12
Bayer Ag
4-FLUOR-3-BROMO-BENZOYL FLUORIDE AND METHOD FOR THE PRODUCTION THEREOF
DE3109966A1
(en)
*
1981-03-14
1982-09-23
Bayer Ag, 5090 Leverkusen
METHOD FOR PRODUCING TRICHLORMETHYL-SUBSTITUTED AROMATIC COMPOUNDS AND TRICHLORMETHYL-SUBSTITUTED COMPOUNDS OBTAINED THEREOF
JPS58222040A
(en)
*
1982-06-18
1983-12-23
Central Glass Co Ltd
Preparation of m-chlorobenzotrifluoride
US4727187A
(en)
*
1984-06-15
1988-02-23
Ciba-Geigy Corporation
Process for the preparation of α, α-difluoroalkyl phenyl ether derivatives
US4966988A
(en)
*
1989-02-17
1990-10-30
Chevron Research Company
Process for preparing acetonitrile 3-trifluoromethyl benzene
CN108558597A
(en)
*
2018-06-07
2018-09-21
天门楚天精细化工有限公司
The synthetic method of 5 bromine benzotrifluoride between a kind of highly effective
CN111620778A
(en)
*
2020-05-28
2020-09-04
吴赣药业（苏州）有限公司
Preparation method of 5-bromo-2-chlorobenzoic acid
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Priority date
Publication date
Assignee
Title
US3258500A
(en)
*
1959-08-17
1966-06-28
Du Pont
Process for fluorinating halohydro-carbons
US3859372A
(en)
*
1969-12-03
1975-01-07
Hooker Chemicals Plastics Corp
Process for the preparation of organic fluorine compounds
DE1965782A1
(en)
*
1969-12-31
1971-07-08
Hoechst Ag
Improved process for the preparation of aromatic trifluoromethyl compounds of the benzene series
CH598163A5
(en)
*
1974-12-19
1978-04-28
Lonza Ag
US4045502A
(en)
*
1976-09-29
1977-08-30
Olin Corporation
Process for producing high purity para-chlorobenzotrifluoride
1977
1977-02-25
DE
DE2708190A
patent/DE2708190C2/en
not_active
Expired
1978
1978-02-10
US
US05/876,821
patent/US4155940A/en
not_active
Expired – Lifetime
1978-02-20
GB
GB6645/78A
patent/GB1574684A/en
not_active
Expired
1978-02-23
CH
CH198578A
patent/CH633244A5/en
not_active
IP Right Cessation
1978-02-23
JP
JP1914178A
patent/JPS53105435A/en
active
Pending
1978-02-24
BE
BE2056704A
patent/BE864280A/en
not_active
IP Right Cessation
1978-02-24
FR
FR7805430A
patent/FR2381733A1/en
active
Granted
Cited By (2)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
EP0216541A1
(en)
*
1985-09-19
1987-04-01
Imperial Chemical Industries Plc
Aryl pyridones
US4725607A
(en)
*
1985-09-19
1988-02-16
Imperial Chemical Industries Plc
Aryl pyridones and insecticidal use thereof
Also Published As
Publication number
Publication date
FR2381733A1
(en)
1978-09-22
FR2381733B1
(en)
1983-12-30
JPS53105435A
(en)
1978-09-13
CH633244A5
(en)
1982-11-30
US4155940A
(en)
1979-05-22
DE2708190A1
(en)
1978-08-31
DE2708190C2
(en)
1984-09-27
BE864280A
(en)
1978-08-24
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Legal Events
Date
Code
Title
Description
1980-11-26
PS
Patent sealed [section 19, patents act 1949]
1986-10-15
PCNP
Patent ceased through non-payment of renewal fee
