GB2030860A - Creation of Inventions and Patents with Artificial Intelligence

GB2030860A – Surgical dressings
– Google Patents

GB2030860A – Surgical dressings
– Google Patents
Surgical dressings

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Publication number
GB2030860A

GB2030860A
GB7910440A
GB7910440A
GB2030860A
GB 2030860 A
GB2030860 A
GB 2030860A
GB 7910440 A
GB7910440 A
GB 7910440A
GB 7910440 A
GB7910440 A
GB 7910440A
GB 2030860 A
GB2030860 A
GB 2030860A
Authority
GB
United Kingdom
Prior art keywords
dressing
backing
insoluble
water
film
Prior art date
1978-02-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Application number
GB7910440A
Other versions

GB2030860B
(en

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Individual

Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1978-02-20
Filing date
1979-03-26
Publication date
1980-04-16

1979-03-26
Application filed by Individual
filed
Critical
Individual

1980-04-16
Publication of GB2030860A
publication
Critical
patent/GB2030860A/en

1982-08-18
Application granted
granted
Critical

1982-08-18
Publication of GB2030860B
publication
Critical
patent/GB2030860B/en

Status
Expired
legal-status
Critical
Current

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Classifications

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES

A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads

A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons

A61L15/42—Use of materials characterised by their function or physical properties

A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices

A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials

A61L2300/202—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with halogen atoms, e.g. triclosan, povidone-iodine

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices

A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action

A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

Abstract

Sterilisable surgical dressings comprise (A) a water-insoluble absorbant backing and, adhered thereto using an adherent means, a water-insoluble, perforated, pliable film of a synthetic polymer, these being incorporated into one or more of the backing, the film and the adherent means, from 0.01 to 5% by weight, based on the total dressing, of a compound of formula: wherein X1 and X3 are each halogen and X2 is hydrogen or halogen.

Description

SPECIFICATION
Surgical dressings
The present invention relates to surgical dressings.
There are already many surgical dressings which are known and which have been successfully marketed. These known dressings are normally sterilisable and function to protect a wound and to provide a buffer against external impacts upon the wounded area.
It has been suggested that surgical dressings could include a bacteriocidal agent to combat any infection of the wound. However, the use of bacteriocides in dressings has proved inconvenient and, moreover, concern has been expressed that bacteriocides may interfere with the complex process of natural healing.
Nonetheless, there is a need for an effective healing aid for use in surgical dressings and a particular group of compounds which are ideal for this purpose has now been found. The compounds in question have proven bacteriostatic properties which they can exert in the vapour phase, thus obviating the need for direct contact between the compound and the wounded area. Still further, the said compounds have been shown to exert an excellent bacteriostatic effect when used in dressings and applied directly on to the wounded area.
Accordingly, the present invention comprises a sterilisable surgical dressing comprising (A) a water-insoluble absorbent backing and, adhered thereto, using an adherent means, a water-insoluble, perforated, pliable film of a synthetic polymer, there being incorporated into one or more of the backing, the film and the adherent means, from 0.01 to 5% by weight, based on the total dressing, of a compound of formula:
wherein X1 and X3 are the same or different and each represents a halogen atom, and X2 is hydrogen or a halogen atom; or (B) a water-insoluble nonabsorbent backing and an absorbent pad, there being incorporated into the pad from 0.01 to 5% by weight, based on the total dressing, of a compound of formula I.
Specific examples of compounds of formula I are:
3-, 4,4′ – trichloro – 2 – hydroxydiphenyl ether 4,4′ – dichloro – 2 – hydroxydiphenyl ether 4 – chloro – 4′ – bromo – 2 – hydroxydiphenyl ether
4 – chloro – 4′ – iodo – 2 – hydroxydiphenyl ether 4 – chloro – 4′ – fluoro – 2 – hydroxydiphenyl ether
4 – bromo – 4′ – chloro – 2 – hydroxydiphenyl ether
4 – bromo – 4′ – chloro – 2 – hydroxydiphenyl ether
4 – bromo – 2′, 4′ – dichloro – 2 – hydroxydiphenyl ether
4, 4′ – dibromo – 2 – hydroxydiphenyl ether and, especially,
2′, 4,4′ – trichloro – 2 – hydroxydiphenyl ether
The water-insoluble backings for the new surgical dressings are preferably capillary, sheeted, nonwoven, fibrous absorbent materials referred to in
British Patent Specification No.778,813, e.g. the product marketed as “Cellucotton”. Preferred water-insoluble film components and adherent compounds are likewise those described at length in Specification 778,813, e.g. “Mylar” film or films of vinyl acetate-crotonic acid plasticised with dibutyl phthalate; and polyvinyl acetate/dibutyl phthalate cements.
The non-absorbent backings may be of conventional type, e.g. an elasticated fabric backing, an opaque plastics backing or a transparent plastics backing. The plastics backing may be waterproof and/or perforated to facilitate aeration of the wounded area. The absorbent pad may be e.g. of lint or gauze.
Advantages of the dressings of the present invention are e.g.:
a) that in the case of a severe wound containing foreign bodies, painful cleaning of the wound can be avoided since the bacteriostatic agent in the dressing successfully controls the bacteria in the wound; and
b) even in the case of sterile wounds e.g. burns, the bacterial situation can be controlled by the use of the new dressings.
The following Examples further illustrate the present invention.
Example 1
A sterile surgical dressing sold under the Trade
Name “Melolin” was modified by incorporating into:
(a) the absorbent backing
(b) the polymer film, or
(c) the cement (or the plasticizer component thereof) adhering the backing to the film, 0.1% by weight, based on the total dressing, of 2′, 4, 4′ – trichloro – 2 – hydroxy diphenyl ether (Irgasan DP 300).
The dressings proved very effective in controlling the development of bacteria present in wounds covered by the dressings.
Example 2
Samples of “Band Aid” plasters were impregnated with 0.1% of 2′, 4,4′ – trichloro – 2 – hydroxydiphenyl ether (IRGASAN DP 300) in the lint padding. The lint padding portions of the plasters so treated were then
placed on agar plates seeded with pure cultures of the bacteria Staphylococcus aureus A TCC 6538,
Escherichia coliNCTC8196, Proteus vulgaris NCIB 4175 and Salmonella typhiNCTC 786. “Band Aid”
plasters containing no IRGASAN DP 300 were used
as controls. The plates were incubated at 37″C for 18
hours and then examined for zones of growth inhibition around the plaster padding. The results are set
out in the following Table:
Plaster S. Aureus E. Coli P. vulgaris S. typhi Sample TCC6538 NCTC 8196 Nib 4175 NCTC786 halo GUS halo GUS halo GUS halo GUS Band Aid 14 – 12 22 11 +DP 300 15 – 13 23 – 12 Band Aid 4 0 + 0 + 0 + No DP 300 4 0 + 0 + 0 + In these results, halos denote zones of growth inhibition (in mm.) and GUS denotes an estimation of
Growth Under the Sample. GUS is assessed as:
+ = no reduction in growth + = slight reduction in growth
– = complete suppression of growth
The results obtained clearly demonstrate that the plasters containing 0.1% of IRGASAN DP 300 showed an excellent bacteriostatic effect against both Gram-positive and Gram-negative organisms, representative of types likely to be associated with wound infection. In contrast, the control samples showed a much lower level of stasis.

Claims (10)

1. Asterilisablesurgical dressing comprising (A) a water-insoluble absorbent backing and, adhered thereto using an adherent means, a water-insoluble, perforated, pliable film of a synthetic polymer, these being incorporated into one or more of the backing, the film and the adherent means, from 0.01 to 5% by weight, based on the total dressing, of a compound of formula:
wherein X, and X3 are the same or different and each represents a halogen atom, and X2 is hydrogen or a halogen atom; or (B) a water-insoluble, nonabsorbent backing and an absorbent pad, there being incorporated into the pad from 0.01 to 5% by weight, based on the total dressing, of a compound of formula I.

2. A dressing as claimed in Claim 1, wherein the compound of formula I is 2′, 4,4′ – trichloro – 2 hydroxydiphenyl ether.

3. A dressing as claimed in Claim 1 or 2, wherein the water-insoluble backing is a capillary, sheeted, non-woven, fibrous, absorbent material described in
British Patent Specification No.778,813.

4. A dressing as claimed in any of the preceding claims, wherein the water-insoluble film and the adherent means are those described in British Patent
Specification No.778,813.

5. A dressing as claimed in Claim 4, wherein the water-insoluble film is a “Mylar” film or is a film of vinyl acetate-crotonic acid plasticised with dibutyl phthalate.

6. A dressing as claimed in Claim 4 or 5, wherein the adherent means is a polyvinyl acetate/dibutyl
phthalate cement.

7. A dressing as claimed in Claim 1 or 2, wherein the non-absorbent backing is an elasticated fabric
backing, or an opaque- or transparent plastics backing.

8. A dressing as claimed in Claim 7, wherein the plastics backing is waterproof and/or perforated to facilitate aeration of the wound.

9. A dressing as claimed in any of Claims 1,2,7 and 8, wherein the absorbent pad is of lint or gauze.

10. A sterilisable surgical dressing substantially as described with reference to either of the Examples.

GB7910440A
1978-02-20
1979-03-26
Surgical dressings

Expired

GB2030860B
(en)

Applications Claiming Priority (2)

Application Number
Priority Date
Filing Date
Title

GB672778

1978-02-20

GB7829481

1978-07-11

Publications (2)

Publication Number
Publication Date

GB2030860A
true

GB2030860A
(en)

1980-04-16

GB2030860B

GB2030860B
(en)

1982-08-18

Family
ID=26240921
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB7910440A
Expired

GB2030860B
(en)

1978-02-20
1979-03-26
Surgical dressings

Country Status (1)

Country
Link

GB
(1)

GB2030860B
(en)

Cited By (4)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

GB2161073A
(en)

1984-06-29
1986-01-08
Alza Corp
Transdermal therapeutic systems

GB2185187A
(en)

1986-01-13
1987-07-15
Alza Corp
Transdermal drug delivery device

EP0889742A1
(en)

1996-03-07
1999-01-13
Leatherite Pty. Ltd.
Improvements in wound care management

WO2002045763A2
(en)

2000-12-07
2002-06-13
Bostik Findley, Inc.
Antimicrobial hot melt adhesive

1979

1979-03-26
GB
GB7910440A
patent/GB2030860B/en
not_active
Expired

Cited By (11)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

GB2161073A
(en)

1984-06-29
1986-01-08
Alza Corp
Transdermal therapeutic systems

US4704282A
(en)

1984-06-29
1987-11-03
Alza Corporation
Transdermal therapeutic system having improved delivery characteristics

US4725439A
(en)

1984-06-29
1988-02-16
Alza Corporation
Transdermal drug delivery device

GB2185187A
(en)

1986-01-13
1987-07-15
Alza Corp
Transdermal drug delivery device

GB2185187B
(en)

1986-01-13
1989-10-25
Alza Corp
Transdermal drug delivery device

EP0889742A1
(en)

1996-03-07
1999-01-13
Leatherite Pty. Ltd.
Improvements in wound care management

EP0889742A4
(en)

1996-03-07
2007-01-03
Leatherite Pty Ltd
Improvements in wound care management

WO2002045763A2
(en)

2000-12-07
2002-06-13
Bostik Findley, Inc.
Antimicrobial hot melt adhesive

WO2002045763A3
(en)

2000-12-07
2003-02-20
Bostik Findley Inc
Antimicrobial hot melt adhesive

US6664309B2
(en)

2000-12-07
2003-12-16
Bostik Findley, Inc.
Antimicrobial hot melt adhesive

CN100348274C
(en)

2000-12-07
2007-11-14
博斯蒂克芬德利公司
Antimicrobial hot melt adhesive

Also Published As

Publication number
Publication date

GB2030860B
(en)

1982-08-18

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