GB1040724A

GB1040724A – Process for the preparation of amino alcohols
– Google Patents

GB1040724A – Process for the preparation of amino alcohols
– Google Patents
Process for the preparation of amino alcohols

Info

Publication number
GB1040724A

GB1040724A
GB13874/66A
GB1387466A
GB1040724A
GB 1040724 A
GB1040724 A
GB 1040724A
GB 13874/66 A
GB13874/66 A
GB 13874/66A
GB 1387466 A
GB1387466 A
GB 1387466A
GB 1040724 A
GB1040724 A
GB 1040724A
Authority
GB
United Kingdom
Prior art keywords
hydrogen
methyl
optically active
chlorine
products
Prior art date
1962-03-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB13874/66A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Evonik Operations GmbH

Original Assignee
Degussa GmbH
Deutsche Gold und Silber Scheideanstalt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1962-03-31
Filing date
1963-03-25
Publication date
1966-09-01

1963-03-25
Application filed by Degussa GmbH, Deutsche Gold und Silber Scheideanstalt
filed
Critical
Degussa GmbH

1966-09-01
Publication of GB1040724A
publication
Critical
patent/GB1040724A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K31/00—Medicinal preparations containing organic active ingredients

A61K31/13—Amines

A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton

C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton

C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated

C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings

C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids

C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom

C—CHEMISTRY; METALLURGY

C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON

C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS

C08F10/00—Homopolymers and copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C2603/00—Systems containing at least three condensed rings

C07C2603/02—Ortho- or ortho- and peri-condensed systems

C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings

C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members

C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings

C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring

C07C2603/18—Fluorenes; Hydrogenated fluorenes

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C2603/00—Systems containing at least three condensed rings

C07C2603/02—Ortho- or ortho- and peri-condensed systems

C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings

C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings

C07C2603/24—Anthracenes; Hydrogenated anthracenes

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C2603/00—Systems containing at least three condensed rings

C07C2603/02—Ortho- or ortho- and peri-condensed systems

C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings

C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings

C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes

Abstract

Novel aminoalcohols of the formula wherein R1, R2 and R3 are each hydrogen or chlorine or a hydroxy, nitro or methoxy radical, R4 is hydrogen, methyl or ethyl, R5, R6 and R7 are hydrogen or methyl, R8 is hydrogen or hydroxyl and R9 and R10 are hydrogen or chlorine or a methyl or methoxy radical, are made by reducing the corresponding b -phenyl-alkylamino -propiophenone, preferably by means of hydrogen in the presence of a catalyst, or with sodium borohydride, lithium borohydride or alkali-metal, alkaline-earth-metal or aluminium alcoholates. The products may be converted into their salts and quaternary compounds. The products may be obtained in optically active forms by reaction with an optically active acid and fractional crystallization or precipitation or by the use of an optically active starting material.

GB13874/66A
1962-03-31
1963-03-25
Process for the preparation of amino alcohols

Expired

GB1040724A
(en)

Applications Claiming Priority (5)

Application Number
Priority Date
Filing Date
Title

DED0038551

1962-03-31

DED0038868

1962-05-09

DED0039477

1962-07-27

DED0040705

1963-01-17

DED0040704

1963-01-17

Publications (1)

Publication Number
Publication Date

GB1040724A
true

GB1040724A
(en)

1966-09-01

Family
ID=27511988
Family Applications (3)

Application Number
Title
Priority Date
Filing Date

GB13874/66A
Expired

GB1040724A
(en)

1962-03-31
1963-03-25
Process for the preparation of amino alcohols

GB11723/63A
Expired

GB1040722A
(en)

1962-03-31
1963-03-25
Process for the preparation of new amino-ketones

GB13873/66A
Expired

GB1040723A
(en)

1962-03-31
1963-03-25
Process for the preparation of new amino ketones

Family Applications After (2)

Application Number
Title
Priority Date
Filing Date

GB11723/63A
Expired

GB1040722A
(en)

1962-03-31
1963-03-25
Process for the preparation of new amino-ketones

GB13873/66A
Expired

GB1040723A
(en)

1962-03-31
1963-03-25
Process for the preparation of new amino ketones

Country Status (11)

Country
Link

US
(1)

US3225095A
(en)

BE
(1)

BE630296A
(en)

BR
(1)

BR6348069D0
(en)

CH
(2)

CH473089A
(en)

DE
(5)

DE1493574A1
(en)

DK
(3)

DK107686C
(en)

FI
(2)

FI42096C
(en)

FR
(1)

FR1353729A
(en)

GB
(3)

GB1040724A
(en)

IT
(1)

IT1061751B
(en)

SE
(3)

SE321241B
(en)

Cited By (15)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US3542870A
(en)

*

1967-01-10
1970-11-24
Houde Lab
1 – (3,5 – dihalo – 4 – hydroxy – phenyl) – 2 – (2-aryloxy or 2 – arylalkyl – isopropylamino)-propanols

FR2117942A1
(en)

*

1970-12-09
1972-07-28
Sumitomo Chemical Co
Substd omega-amino alkyl phenyl ketones prepn – – from corresp omega-acid amide

WO2001042193A1
(en)

*

1999-12-08
2001-06-14
Theravance, Inc.
β2-ADRENERGIC RECEPTOR AGONISTS

US6362371B1
(en)

1998-06-08
2002-03-26
Advanced Medicine, Inc.
β2- adrenergic receptor agonists

JP2003516381A
(en)

*

1999-12-08
2003-05-13
セラヴァンス インコーポレーテッド

β-adrenergic receptor agonist

US6593497B1
(en)

1999-06-02
2003-07-15
Theravance, Inc.
β2-adrenergic receptor agonists

US6653323B2
(en)

2001-11-13
2003-11-25
Theravance, Inc.
Aryl aniline β2 adrenergic receptor agonists

US6670376B1
(en)

2001-11-13
2003-12-30
Theravance, Inc.
Aryl aniline β2 adrenergic receptor agonists

US6683115B2
(en)

1999-06-02
2004-01-27
Theravance, Inc.
β2-adrenergic receptor agonists

US6713651B1
(en)

1999-06-07
2004-03-30
Theravance, Inc.
β2-adrenergic receptor agonists

US6747043B2
(en)

2002-05-28
2004-06-08
Theravance, Inc.
Alkoxy aryl β2 adrenergic receptor agonists

US7399863B2
(en)

2003-09-22
2008-07-15
Theravance, Inc.
Amino-substituted ethylamino β2 adrenergic receptor agonists

US7402673B2
(en)

2004-06-03
2008-07-22
Theravance, Inc.
Diamine β2 adrenergic receptor agonists

US7566785B2
(en)

2004-09-10
2009-07-28
Theravance, Inc.
Amidine substituted aryl aniline compounds

US7622467B2
(en)

2004-01-12
2009-11-24
Theravance, Inc.
Aryl aniline derivatives as β2 adrenergic receptor agonists

Families Citing this family (15)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

FR95908E
(en)

*

1963-11-09
1972-01-31
Degussa

Process for the preparation of novel aminoketones and corresponding secondary alcohols.

DE1234707B
(en)

*

1964-08-29
1967-02-23
Degussa

Process for the preparation of unsaturated amino compounds

US3525771A
(en)

*

1964-09-09
1970-08-25
Hoffmann La Roche
3-(3-hydroxy-3-phenyl-butylamino) propiophenones

DE1593836A1
(en)

*

1967-06-29
1971-08-19
Degussa

Process for the preparation of new aminoketones

FR2068435A1
(en)

*

1969-11-18
1971-08-27
Degussa
Phenethylamino-propiophenones

US4010191A
(en)

*

1969-12-18
1977-03-01
Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler
Acyl derivatives of substituted bis-arylalkylamino compounds

DE2008654A1
(en)

*

1970-02-25
1971-09-09
C H Boehnnger Sohn, 6507 Ingel heim

Ammoathanoldenvate

DE2116293A1
(en)

*

1971-04-02
1972-10-19
Cassella Farbwerke Mainkur Ag, 6000 Frankfurt

Ketone derivatives and processes for their preparation

FI70205C
(en)

*

1978-05-17
1986-09-15
Degussa

FOERFARANDE FOER FRAMSTAELLNING AV NYA TERAPEUTISKT ANVAENDBARA L- / 3-HYDROXI-3-PHENYLPROPYL- (2) / – / 3-OXO-PROPYL / AMINER

US4279929A
(en)

*

1980-01-25
1981-07-21
Shell Oil Company
N-Phenethylaminopropiophenones as lipogenesis inhibitors

US4305960A
(en)

*

1980-01-25
1981-12-15
Shell Oil Company
N-Phenethylaminopropiophenones as lipogenesis inhibitors

US4279925A
(en)

*

1980-01-25
1981-07-21
Shell Oil Company
N-Phenethylaminopropiophenones as lipogenesis inhibitors

US4285970A
(en)

*

1980-01-25
1981-08-25
Shell Oil Company
N-Phenethylaminopropiophenones as lipogenesis inhibitors

US4276307A
(en)

*

1980-01-25
1981-06-30
Shell Oil Company
N-Phenethylaminopropiophenones as lipogenesis inhibitors

FR2845288B1
(en)

*

2002-10-03
2006-05-19
Oreal

COMPOSITION, PARTICULARLY COSMETIC, COMPRISING A CARBONYLATED SECONDARY OR TERTIARY AMINE

Family Cites Families (4)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US1911332A
(en)

*

1930-01-18
1933-05-30
Hoffmann La Roche
Aminoketoalcohol and process for the manufacture of same

US2489668A
(en)

*

1947-01-11
1949-11-29
Hoffmann La Roche
Process for preparing nu-di(beta benzoylethyl)-lower alkylamines

US2661373A
(en)

*

1953-03-02
1953-12-01
Kulz Ida
Certain amino alcohols and ketones

US2900415A
(en)

*

1954-12-14
1959-08-18
Lakeside Lab Inc
Synthesized antispasmodic compounds

0

BE
BE630296D
patent/BE630296A/xx
unknown

DE
DENDAT1250450D
patent/DE1250450B/en
active
Pending

1962

1962-03-31
DE
DE19621493574
patent/DE1493574A1/en
active
Pending

1962-07-27
DE
DE19621493576
patent/DE1493576A1/en
active
Pending

1963

1963-01-17
DE
DE19631493580
patent/DE1493580A1/en
active
Pending

1963-01-17
DE
DE19631493579
patent/DE1493579B1/en
active
Pending

1963-03-01
FR
FR926522A
patent/FR1353729A/en
not_active
Expired

1963-03-22
CH
CH367163A
patent/CH473089A/en
not_active
IP Right Cessation

1963-03-22
IT
IT05576/63A
patent/IT1061751B/en
active

1963-03-22
CH
CH1810066A
patent/CH499493A/en
not_active
IP Right Cessation

1963-03-25
GB
GB13874/66A
patent/GB1040724A/en
not_active
Expired

1963-03-25
GB
GB11723/63A
patent/GB1040722A/en
not_active
Expired

1963-03-25
GB
GB13873/66A
patent/GB1040723A/en
not_active
Expired

1963-03-28
US
US268579A
patent/US3225095A/en
not_active
Expired – Lifetime

1963-03-29
FI
FI630586A
patent/FI42096C/en
active

1963-03-29
BR
BR148069/63A
patent/BR6348069D0/en
unknown

1963-03-29
SE
SE13788/64A
patent/SE321241B/xx
unknown

1963-03-29
SE
SE3477/63A
patent/SE304278B/xx
unknown

1963-03-30
DK
DK116365AA
patent/DK107686C/en
active

1963-03-30
DK
DK116265AA
patent/DK107685C/en
active

1963-03-30
DK
DK148363AA
patent/DK107490C/en
active

1964

1964-11-16
SE
SE1378964A
patent/SE304017B/xx
unknown

1969

1969-01-14
FI
FI690100A
patent/FI42098C/en
active

Cited By (24)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US3542870A
(en)

*

1967-01-10
1970-11-24
Houde Lab
1 – (3,5 – dihalo – 4 – hydroxy – phenyl) – 2 – (2-aryloxy or 2 – arylalkyl – isopropylamino)-propanols

FR2117942A1
(en)

*

1970-12-09
1972-07-28
Sumitomo Chemical Co
Substd omega-amino alkyl phenyl ketones prepn – – from corresp omega-acid amide

US6541669B1
(en)

1998-06-08
2003-04-01
Theravance, Inc.
β2-adrenergic receptor agonists

US6919482B2
(en)

1998-06-08
2005-07-19
Theravance, Inc.
β2-adrenergic receptor agonists

US6362371B1
(en)

1998-06-08
2002-03-26
Advanced Medicine, Inc.
β2- adrenergic receptor agonists

US6593497B1
(en)

1999-06-02
2003-07-15
Theravance, Inc.
β2-adrenergic receptor agonists

US6916961B2
(en)

1999-06-02
2005-07-12
Theravance, Inc.
β2-adrenergic receptor agonists

US6683115B2
(en)

1999-06-02
2004-01-27
Theravance, Inc.
β2-adrenergic receptor agonists

US6713651B1
(en)

1999-06-07
2004-03-30
Theravance, Inc.
β2-adrenergic receptor agonists

US7211695B2
(en)

1999-06-07
2007-05-01
Theravance, Inc.
β2-adrenergic receptor agonists

US7105701B2
(en)

1999-06-07
2006-09-12
Theravance, Inc.
β2-adrenergic receptor agonists

WO2001042193A1
(en)

*

1999-12-08
2001-06-14
Theravance, Inc.
β2-ADRENERGIC RECEPTOR AGONISTS

US6576793B1
(en)

1999-12-08
2003-06-10
Theravance, Inc.
β2-adrenergic receptor agonists

JP2003516381A
(en)

*

1999-12-08
2003-05-13
セラヴァンス インコーポレーテッド

β-adrenergic receptor agonist

JP4703081B2
(en)

*

1999-12-08
2011-06-15
セラヴァンス， インコーポレーテッド

β-adrenergic receptor agonist

US6670376B1
(en)

2001-11-13
2003-12-30
Theravance, Inc.
Aryl aniline β2 adrenergic receptor agonists

US6653323B2
(en)

2001-11-13
2003-11-25
Theravance, Inc.
Aryl aniline β2 adrenergic receptor agonists

US6747043B2
(en)

2002-05-28
2004-06-08
Theravance, Inc.
Alkoxy aryl β2 adrenergic receptor agonists

US7399863B2
(en)

2003-09-22
2008-07-15
Theravance, Inc.
Amino-substituted ethylamino β2 adrenergic receptor agonists

US7964730B2
(en)

2003-09-22
2011-06-21
Theravance, Inc.
Amino-substituted ethylamino β2 adrenergic receptor agonists

US7622467B2
(en)

2004-01-12
2009-11-24
Theravance, Inc.
Aryl aniline derivatives as β2 adrenergic receptor agonists

US7994165B2
(en)

2004-01-12
2011-08-09
Theravance, Inc.
Aryl aniline derivatives as β2 adrenergic receptor agonists

US7402673B2
(en)

2004-06-03
2008-07-22
Theravance, Inc.
Diamine β2 adrenergic receptor agonists

US7566785B2
(en)

2004-09-10
2009-07-28
Theravance, Inc.
Amidine substituted aryl aniline compounds

Also Published As

Publication number
Publication date

DE1250450B
(en)

1967-09-21

CH499493A
(en)

1970-11-30

SE304017B
(en)

1968-09-16

DK107490C
(en)

1967-06-05

GB1040722A
(en)

1966-09-01

DE1493580A1
(en)

1969-03-27

DK107686C
(en)

1967-06-26

BR6348069D0
(en)

1973-06-12

CH473089A
(en)

1969-05-31

FR1353729A
(en)

1964-02-28

BE630296A
(en)

DE1493574A1
(en)

1969-03-06

DK107685C
(en)

1967-06-26

IT1061751B
(en)

1983-04-30

SE304278B
(en)

1968-09-23

FI42096B
(en)

1970-02-02

FI42098B
(en)

1970-02-02

FI42096C
(en)

1970-05-11

DE1493576A1
(en)

1969-03-27

DE1493579B1
(en)

1971-08-26

US3225095A
(en)

1965-12-21

FI42098C
(en)

1970-05-11

GB1040723A
(en)

1966-09-01

SE321241B
(en)

1970-03-02

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