GB1072771A

GB1072771A – Pharmaceutical compositions comprising uricasuric agents and 3-indolyl aliphatic acid derivatives
– Google Patents

GB1072771A – Pharmaceutical compositions comprising uricasuric agents and 3-indolyl aliphatic acid derivatives
– Google Patents
Pharmaceutical compositions comprising uricasuric agents and 3-indolyl aliphatic acid derivatives

Info

Publication number
GB1072771A

GB1072771A
GB26806/64A
GB2680664A
GB1072771A
GB 1072771 A
GB1072771 A
GB 1072771A
GB 26806/64 A
GB26806/64 A
GB 26806/64A
GB 2680664 A
GB2680664 A
GB 2680664A
GB 1072771 A
GB1072771 A
GB 1072771A
Authority
GB
United Kingdom
Prior art keywords
alkyl
alkoxy
halo
amino
indolyl
Prior art date
1963-07-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB26806/64A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck and Co Inc

Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1963-07-15
Filing date
1964-06-29
Publication date
1967-06-21

1964-06-29
Application filed by Merck and Co Inc
filed
Critical
Merck and Co Inc

1967-06-21
Publication of GB1072771A
publication
Critical
patent/GB1072771A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom

C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring

C07D209/04—Indoles; Hydrogenated indoles

C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring

C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom

C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K31/00—Medicinal preparations containing organic active ingredients

A61K31/33—Heterocyclic compounds

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K31/00—Medicinal preparations containing organic active ingredients

A61K31/33—Heterocyclic compounds

A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins

A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil

A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole

A61K31/404—Indoles, e.g. pindolol

A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K31/00—Medicinal preparations containing organic active ingredients

A61K31/33—Heterocyclic compounds

A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins

A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole

A61K31/415—1,2-Diazoles

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K31/00—Medicinal preparations containing organic active ingredients

A61K31/33—Heterocyclic compounds

A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins

A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole

A61K31/42—Oxazoles

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K31/00—Medicinal preparations containing organic active ingredients

A61K31/33—Heterocyclic compounds

A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins

A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom

A61K31/47—Quinolines; Isoquinolines

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K31/00—Medicinal preparations containing organic active ingredients

A61K31/33—Heterocyclic compounds

A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins

A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines

A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim

A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

A61K31/52—Purines, e.g. adenine

Abstract

Compositions for treating gout comprise an a -3-indolyl C2-7 monocarboxylic aliphatic acid having an acyl radical of an aromatic carboxylic acid or an aromatic-substituted methyl group in the 1-indolyl position, or an amide, ester, or salt of such a compound, and a uricosuric agent together with a diluent or carrier. Preferred uricosuric agents are N,N-dialkyl-p-sulfamoyl benzoic acids and salts thereof; 2-phenyl-quinoline 4-carboxylic acid, its 6-methyl derivative, and the ethyl esters thereof; 2-amino-5-chloro-benzoxazole; and 1, 2-diaryl-4-alkyl-3,5-pyrazolidinediones e.g. 1,2-diphenyl-4-butyl-3,5-pyrazolidinedione. The compositions may be administered orally or parenterally. Preferred indolyl derivatives, of which many examples are given, include those of the general formula in which R1 is an aromatic radical of 1 or 2 fused 5- or 6-membered rings in which any hetero atoms present are O, N, or S, there being not more than 3 such hetero atoms present in no more than one of the rings, said aromatic radical being optionally substituted by 1 or more of the following radicals:-hydroxy, C1-5 alkyl, C1-5 alkoxy, phenoxy, nitro, halogen, C1-6 alkanoylamino, di C1-5 alkylamino, mercapto, C1-5 alkylthio, halo C1-5 alkylthio, benzylthio, benzyloxy, phenylthio, halo C1-5 alkyl, C1-6 alkanoyl, halo C1-6 alkanoyl, halo C1-5 alkoxy, cyano, di C1-5 alkyl sulfonamido, carb-C1-5-alkoxy, aldehyde, di C1-5 alkylcarboxamido, phenyl, C1-5 alkylsulfinyl, or C1-5 alkylsulfonyl; R2 is H or C1-5 alkyl; R3 is H or C1-5 alkyl; R4 is H or R3 and R4 together represent a methylene group or together with the a -carbon atom to which they are attached form a cyclopropyl ring; R5 is H or F or hydroxy, C1-5 alkyl, C1-5 alkoxy, C2-5 alkenyl, polyfluoromethyl, nitro, amino, morpholinyl, N-methyl piperazinyl, bis-(hydroxyethyl)amino, C1-6 alkanoylamino, C1-5 alkyl di C1-5 alkylamino, N-pyrrolidinyl, N-azacyclopropyl, cyano, aminomethyl, dimethyl-aminomethyl, dimethylsulfamoyl, or mercapto; and M is a hydroxy, amino, benzyloxy, C1-5 alkoxy or -OZ radical where Z is a cation.

GB26806/64A
1963-07-15
1964-06-29
Pharmaceutical compositions comprising uricasuric agents and 3-indolyl aliphatic acid derivatives

Expired

GB1072771A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

US29518763A

1963-07-15
1963-07-15

Publications (1)

Publication Number
Publication Date

GB1072771A
true

GB1072771A
(en)

1967-06-21

Family
ID=23136613
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB26806/64A
Expired

GB1072771A
(en)

1963-07-15
1964-06-29
Pharmaceutical compositions comprising uricasuric agents and 3-indolyl aliphatic acid derivatives

Country Status (5)

Country
Link

BE
(1)

BE650350A
(en)

FR
(1)

FR4143M
(en)

GB
(1)

GB1072771A
(en)

IL
(1)

IL21582A
(en)

NL
(4)

NL6408031A
(en)

Cited By (2)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

WO2001051489A2
(en)

*

2000-01-14
2001-07-19
The Institutes For Pharmaceutical Discovery, Llc
Methods for lowering uric acid levels

US20210393564A1
(en)

*

2020-04-10
2021-12-23
University Of Georgia Research Foundation, Inc.
Methods of using probenecid for treatment of coronavirus infections

1964

1964-06-23
IL
IL2158264A
patent/IL21582A/en
unknown

1964-06-29
GB
GB26806/64A
patent/GB1072771A/en
not_active
Expired

1964-07-09
BE
BE650350D
patent/BE650350A/en
unknown

1964-07-14
NL
NL6408031A
patent/NL6408031A/xx
unknown

1964-10-09
FR
FR990985A
patent/FR4143M/fr
not_active
Expired

1970

1970-06-17
NL
NL7008875A
patent/NL7008875A/xx
unknown

1970-06-17
NL
NL7008877A
patent/NL7008877A/xx
unknown

1970-06-17
NL
NL7008876A
patent/NL7008876A/xx
unknown

Cited By (3)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

WO2001051489A2
(en)

*

2000-01-14
2001-07-19
The Institutes For Pharmaceutical Discovery, Llc
Methods for lowering uric acid levels

WO2001051489A3
(en)

*

2000-01-14
2001-12-27
Inst For Pharm Discovery Inc
Methods for lowering uric acid levels

US20210393564A1
(en)

*

2020-04-10
2021-12-23
University Of Georgia Research Foundation, Inc.
Methods of using probenecid for treatment of coronavirus infections

Also Published As

Publication number
Publication date

FR4143M
(en)

1966-05-09

NL7008876A
(en)

1970-10-26

NL7008877A
(en)

1970-10-26

NL7008875A
(en)

1970-10-26

IL21582A
(en)

1968-08-22

BE650350A
(en)

1965-01-11

NL6408031A
(en)

1965-01-18

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