GB1084996A

GB1084996A – Dibenzocyclohepten-5-yl-acetic acid esters
– Google Patents

GB1084996A – Dibenzocyclohepten-5-yl-acetic acid esters
– Google Patents
Dibenzocyclohepten-5-yl-acetic acid esters

Info

Publication number
GB1084996A

GB1084996A
GB47786/63A
GB4778663A
GB1084996A
GB 1084996 A
GB1084996 A
GB 1084996A
GB 47786/63 A
GB47786/63 A
GB 47786/63A
GB 4778663 A
GB4778663 A
GB 4778663A
GB 1084996 A
GB1084996 A
GB 1084996A
Authority
GB
United Kingdom
Prior art keywords
formula
alkyl
radical
acid addition
group
Prior art date
1963-12-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB47786/63A
Inventor
Cordelis Van Der Stelt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Koninklijke Pharmaceutische Fabrieken NV

Original Assignee
Koninklijke Pharmaceutische Fabrieken NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1963-12-03
Filing date
1963-12-03
Publication date
1967-09-27

Priority to NL125839D
priority
Critical
patent/NL125839C/xx

1963-12-03
Priority to GB47786/63A
priority
patent/GB1084996A/en

1963-12-03
Application filed by Koninklijke Pharmaceutische Fabrieken NV
filed
Critical
Koninklijke Pharmaceutische Fabrieken NV

1964-07-27
Priority claimed from US385455A
external-priority
patent/US3324138A/en

1964-07-27
Priority to US385455A
priority
patent/US3324138A/en

1964-09-10
Priority to BR162496/64A
priority
patent/BR6462496D0/en

1964-10-09
Priority to FR990881A
priority
patent/FR1518578A/en

1964-11-01
Priority to IL22359A
priority
patent/IL22359A/en

1964-11-11
Priority to FI2362/64A
priority
patent/FI42825B/fi

1964-11-28
Priority to NO155795A
priority
patent/NO120680B/no

1964-12-01
Priority to BE656483A
priority
patent/BE656483A/xx

1964-12-02
Priority to DE19641468425
priority
patent/DE1468425A1/en

1964-12-02
Priority to CH1554664A
priority
patent/CH465596A/en

1964-12-02
Priority to SE14558/64A
priority
patent/SE318868B/xx

1964-12-02
Priority to NL6413980A
priority
patent/NL6413980A/xx

1964-12-02
Priority to ES0306937A
priority
patent/ES306937A1/en

1967-09-27
Publication of GB1084996A
publication
Critical
patent/GB1084996A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms

C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid

C07C57/50—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid containing condensed ring systems

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof

C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system

C07D451/06—Oxygen atoms

C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids

C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Abstract

Novel compounds of the Formula I, wherein X represents an ethylene or ethylene radical, each of R1 and R2 represents a hydrogen or halogen atom or a C1- 7 alkyl group and R3 represents (a) a group of the formula -A-B, wherein A represent a C1- 7 alkylene radical and B represents a C1- 7 alkylamino, di-(C1- 7 alkyl) amino, piperidino, pyrrolidino, morpholino or thiamorpholino radical or (b) a group of the Formula II (wherein R4 represents a hydrogen atom or a C1- 7 alkyl group and n represents 1 or 2), or (c) a saturated bicyclic nitrogen-containing heterocyclic radical of less than 12 carbon atoms, optionally carrying a C1- 7 alkyl or aryl-C1- 7 alkyl substituent, and non-toxic acid addition salts thereof, are prepared by reacting in an inert solvent under esterification conditions an acid of the Formula III or a reactive functional derivative thereof with an alcohol of the formula R3OH or by reacting in an inert solvent a salt of said acid with a reactive-functional derivative of said alcohol, and, if desired, converting a resultant product into a non-toxic acid addition salt thereof. Therapeutic compositions with cardiac regulatory properties in forms suitable for oral or parenteral administration comprise compounds of the Formula I or non-toxic acid addition salts thereof in association with pharmaceutically acceptable carriers.

GB47786/63A
1963-12-03
1963-12-03
Dibenzocyclohepten-5-yl-acetic acid esters

Expired

GB1084996A
(en)

Priority Applications (14)

Application Number
Priority Date
Filing Date
Title

NL125839D

NL125839C
(en)

1963-12-03

GB47786/63A

GB1084996A
(en)

1963-12-03
1963-12-03
Dibenzocyclohepten-5-yl-acetic acid esters

US385455A

US3324138A
(en)

1963-12-03
1964-07-27
Quinuclidin-3-yl-ester of 10, 11-dihydro-5h-dibenzo[a, d]cyclohepten-5-yl-acetic acid

BR162496/64A

BR6462496D0
(en)

1963-12-03
1964-09-10

PROCESS TO PREPARE HEPTEY-5-IL-ACETIC DI-BENZO ACID ESTERS

FR990881A

FR1518578A
(en)

1963-12-03
1964-10-09

Process for the preparation of new esters of dibenzocyclohepten-5-yl-acetic acid

IL22359A

IL22359A
(en)

1963-12-03
1964-11-01
Dibenzocycloheptenyl acetic acids,their esters,and process for their preparation

FI2362/64A

FI42825B
(en)

1963-12-03
1964-11-11

NO155795A

NO120680B
(en)

1963-12-03
1964-11-28

BE656483A

BE656483A
(en)

1963-12-03
1964-12-01

DE19641468425

DE1468425A1
(en)

1963-12-03
1964-12-02

Process for the preparation of dibenzocyclohepten-5-ylessigic acid esters

CH1554664A

CH465596A
(en)

1963-12-03
1964-12-02

Process for the preparation of 5H-dibenzocyclohepten- or 10,11-dihydro-5H-dibenzocyclohepten-5-yl-acetic acid esters

SE14558/64A

SE318868B
(en)

1963-12-03
1964-12-02

NL6413980A

NL6413980A
(en)

1963-12-03
1964-12-02

ES0306937A

ES306937A1
(en)

1963-12-03
1964-12-02
Procedure for the preparation of acid steres dibenzociclohepten-5-il-acetico. (Machine-translation by Google Translate, not legally binding)

Applications Claiming Priority (2)

Application Number
Priority Date
Filing Date
Title

GB47786/63A

GB1084996A
(en)

1963-12-03
1963-12-03
Dibenzocyclohepten-5-yl-acetic acid esters

US385455A

US3324138A
(en)

1963-12-03
1964-07-27
Quinuclidin-3-yl-ester of 10, 11-dihydro-5h-dibenzo[a, d]cyclohepten-5-yl-acetic acid

Publications (1)

Publication Number
Publication Date

GB1084996A
true

GB1084996A
(en)

1967-09-27

Family
ID=26266134
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB47786/63A
Expired

GB1084996A
(en)

1963-12-03
1963-12-03
Dibenzocyclohepten-5-yl-acetic acid esters

Country Status (10)

Country
Link

BE
(1)

BE656483A
(en)

BR
(1)

BR6462496D0
(en)

CH
(1)

CH465596A
(en)

DE
(1)

DE1468425A1
(en)

FI
(1)

FI42825B
(en)

GB
(1)

GB1084996A
(en)

IL
(1)

IL22359A
(en)

NL
(2)

NL6413980A
(en)

NO
(1)

NO120680B
(en)

SE
(1)

SE318868B
(en)

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US4412999A
(en)

*

1982-04-14
1983-11-01
Merck & Co., Inc.
Anti-emetic esters of cyproheptadine-3-carboxylic acid and structurally related compounds

0

NL
NL125839D
patent/NL125839C/xx
active

1963

1963-12-03
GB
GB47786/63A
patent/GB1084996A/en
not_active
Expired

1964

1964-09-10
BR
BR162496/64A
patent/BR6462496D0/en
unknown

1964-11-01
IL
IL22359A
patent/IL22359A/en
unknown

1964-11-11
FI
FI2362/64A
patent/FI42825B/fi
active

1964-11-28
NO
NO155795A
patent/NO120680B/no
unknown

1964-12-01
BE
BE656483A
patent/BE656483A/xx
unknown

1964-12-02
SE
SE14558/64A
patent/SE318868B/xx
unknown

1964-12-02
CH
CH1554664A
patent/CH465596A/en
unknown

1964-12-02
DE
DE19641468425
patent/DE1468425A1/en
active
Pending

1964-12-02
NL
NL6413980A
patent/NL6413980A/xx
unknown

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US4412999A
(en)

*

1982-04-14
1983-11-01
Merck & Co., Inc.
Anti-emetic esters of cyproheptadine-3-carboxylic acid and structurally related compounds

Also Published As

Publication number
Publication date

NO120680B
(en)

1970-11-23

NL125839C
(en)

BE656483A
(en)

1965-04-01

NL6413980A
(en)

1965-06-04

FI42825B
(en)

1970-08-03

DE1468425A1
(en)

1969-05-29

CH465596A
(en)

1968-11-30

SE318868B
(en)

1969-12-22

IL22359A
(en)

1968-07-25

BR6462496D0
(en)

1973-08-07

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