GB1087243A

GB1087243A – Improvements in or relating to naphthalene derivatives and the manufacture thereof
– Google Patents

GB1087243A – Improvements in or relating to naphthalene derivatives and the manufacture thereof
– Google Patents
Improvements in or relating to naphthalene derivatives and the manufacture thereof

Info

Publication number
GB1087243A

GB1087243A
GB6087/67A
GB608767A
GB1087243A
GB 1087243 A
GB1087243 A
GB 1087243A
GB 6087/67 A
GB6087/67 A
GB 6087/67A
GB 608767 A
GB608767 A
GB 608767A
GB 1087243 A
GB1087243 A
GB 1087243A
Authority
GB
United Kingdom
Prior art keywords
agents
alkyl
halogen
compounds
alkylenedioxy
Prior art date
1963-10-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB6087/67A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pharmacia and Upjohn Co

Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1963-10-16
Filing date
1964-09-15
Publication date
1967-10-18

1964-09-15
Application filed by Upjohn Co
filed
Critical
Upjohn Co

1967-10-18
Publication of GB1087243A
publication
Critical
patent/GB1087243A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates

C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring

C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds

C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation

C07C45/46—Friedel-Crafts reactions

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds

C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups

C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton

C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds

C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups

C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton

C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms

C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups

C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates

C07C49/587—Unsaturated compounds containing a keto groups being part of a ring

C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups

C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates

C07C49/587—Unsaturated compounds containing a keto groups being part of a ring

C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups

C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring

Abstract

Compounds of the general formula (I) are prepared by the following route: The intermediates of Formula (V) may alternatively be prepared by the following route: Compounds (I) may be converted to acid addition and quaternary ammonium salts and the latter may be converted to different salts, e.g. via the corresponding hydroxide. In the above formulae R1 is C1- 8 alkyl, halogen, tri-fluoromethyl or C1- 8 alkylenedioxy, and when more than one R1 substituent is present these can be the same or different, x is 0-4 (provided that when R1 is alkylenedioxy, x does not represent 3 or 4), R2 is hydrogen, C1- 8 alkyl, phenyl or phenyl substituted by at least one radical selected from C1- 8 alkyl and halogen, CnH2n is a C2- 6 alkylene radical, R3 and R4 are C1- 8 alkyl or are linked together to form, with the attached nitrogen atom, a 5-7 ring atom saturated heterocyclic radical, and Hal is halogen. The compounds of the invention are antifertility agents, anti-oestrogenic agents, gonadotrophin-inhibiting agents, agents for lowering lipid and cholesterol blood levels, anti-inflammatory agents and central nervous system stimulants, and may be administered in the form of pharmaceutical or veterinary preparations containing them together with a carrier.

GB6087/67A
1963-10-16
1964-09-15
Improvements in or relating to naphthalene derivatives and the manufacture thereof

Expired

GB1087243A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

US316549A

US3313853A
(en)

1963-10-16
1963-10-16
2-(tertiaryaminoalkoxyphenyl)-3, 4-dihydronaphthalenes and 2-(tertiaryaminoalkoxyphenyl) -3, 4- dihydro -1(2h)-naphthalenones

Publications (1)

Publication Number
Publication Date

GB1087243A
true

GB1087243A
(en)

1967-10-18

Family
ID=23229511
Family Applications (2)

Application Number
Title
Priority Date
Filing Date

GB37662/64A
Expired

GB1087242A
(en)

1963-10-16
1964-09-15
Improvements in or relating to naphthalene derivatives and the manufacture thereof

GB6087/67A
Expired

GB1087243A
(en)

1963-10-16
1964-09-15
Improvements in or relating to naphthalene derivatives and the manufacture thereof

Family Applications Before (1)

Application Number
Title
Priority Date
Filing Date

GB37662/64A
Expired

GB1087242A
(en)

1963-10-16
1964-09-15
Improvements in or relating to naphthalene derivatives and the manufacture thereof

Country Status (9)

Country
Link

US
(1)

US3313853A
(en)

BE
(1)

BE654469A
(en)

BR
(1)

BR6463480D0
(en)

CH
(1)

CH472369A
(en)

DE
(1)

DE1493340A1
(en)

GB
(2)

GB1087242A
(en)

IL
(1)

IL22059A
(en)

NL
(1)

NL6412097A
(en)

SE
(1)

SE345257B
(en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US3506653A
(en)

*

1966-09-12
1970-04-14
Syntex Corp
Non-steroid hormonal agents

US4179558A
(en)

*

1978-01-30
1979-12-18
E. R. Squibb & Sons, Inc.
Naphthalenone derivatives and analogs

US5225436A
(en)

*

1987-05-15
1993-07-06
Schering Corporation
Aryl substituted naphthalene derivatives

JPH02501737A
(en)

*

1987-05-15
1990-06-14
シェリング・コーポレーション

Aryl-substituted naphthalenes, benzoxepines, benzazepines, benzocycloheptene derivatives

US5416098A
(en)

*

1993-12-30
1995-05-16
Zymogenetics, Inc.
Method for treating dermatitis and related conditions

US7501441B1
(en)

1994-09-20
2009-03-10
Eli Lilly And Company
Naphthyl compounds, intermediates, processes, compositions, and methods

US6703407B1
(en)

1994-09-20
2004-03-09
Eli Lilly And Company
Benzofuran compounds, compositions, and methods

US5492921A
(en)

*

1994-09-20
1996-02-20
Eli Lilly And Company
Benzothiophene compounds, compositions, and methods for inhibiting aortal smooth muscle proliferation

US5446071A
(en)

*

1994-11-18
1995-08-29
Eli Lilly And Company
Methods for lowering serum cholesterol

US5998401A
(en)

1995-02-28
1999-12-07
Eli Lilly And Company
Naphthyl compounds, intermediates, compositions, and methods

US6391892B1
(en)

*

1995-03-10
2002-05-21
Eli Lilly And Company
Naphthyl pharmaceutical compounds

US6384053B1
(en)

1995-03-10
2002-05-07
Eli Lilly And Company
α-substituted-1-benzyl-napthyls

US6440958B1
(en)

1995-06-26
2002-08-27
Eli Lilly And Company
Acrylic and propionic acid compounds, intermediates, processes, compositions, and methods

US5811421A
(en)

*

1995-07-31
1998-09-22
Eli Lilly And Company
Naphthyl and dihydronaphthyl intermediates, compounds, compositions, and methods

US6350884B1
(en)

1996-06-25
2002-02-26
Eli Lilly And Company
Acrylic and propionic acid compounds, intermediates, processes, compositions, and method

US5916916A
(en)

*

1996-10-10
1999-06-29
Eli Lilly And Company
1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods

US5929090A
(en)

*

1997-09-12
1999-07-27
Eli Lilly And Company
2-aryl-3-aminoaryloxynaphthy1 compounds, intermediates, compositions and methods

Family Cites Families (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US3234211A
(en)

*

1962-10-24
1966-02-08
Ciba Geigy Corp
Tertiaryaminoalkoxy alkylene monocyclic carbocyclic aryltetrahydro naphthalenes, indanes, indenes and homologs thereof

1963

1963-10-16
US
US316549A
patent/US3313853A/en
not_active
Expired – Lifetime

1964

1964-09-10
IL
IL22059A
patent/IL22059A/en
unknown

1964-09-15
GB
GB37662/64A
patent/GB1087242A/en
not_active
Expired

1964-09-15
GB
GB6087/67A
patent/GB1087243A/en
not_active
Expired

1964-09-28
CH
CH1255364A
patent/CH472369A/en
not_active
IP Right Cessation

1964-10-13
DE
DE19641493340
patent/DE1493340A1/en
active
Pending

1964-10-15
SE
SE12428/64A
patent/SE345257B/xx
unknown

1964-10-16
BE
BE654469A
patent/BE654469A/xx
unknown

1964-10-16
NL
NL6412097A
patent/NL6412097A/xx
unknown

1964-10-16
BR
BR163480/64A
patent/BR6463480D0/en
unknown

Also Published As

Publication number
Publication date

IL22059A
(en)

1968-03-28

CH472369A
(en)

1969-05-15

GB1087242A
(en)

1967-10-18

SE345257B
(en)

1972-05-23

US3313853A
(en)

1967-04-11

DE1493340A1
(en)

1969-06-04

NL6412097A
(en)

1965-04-20

BE654469A
(en)

1965-04-16

BR6463480D0
(en)

1973-07-17

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