GB1135966A – Improvements in or relating to sustained-release medicaments
– Google Patents
GB1135966A – Improvements in or relating to sustained-release medicaments
– Google Patents
Improvements in or relating to sustained-release medicaments
Info
Publication number
GB1135966A
GB1135966A
GB832/67A
GB83267A
GB1135966A
GB 1135966 A
GB1135966 A
GB 1135966A
GB 832/67 A
GB832/67 A
GB 832/67A
GB 83267 A
GB83267 A
GB 83267A
GB 1135966 A
GB1135966 A
GB 1135966A
Authority
GB
United Kingdom
Prior art keywords
jan
medicament
ethylene glycol
sustained
hydrogel
Prior art date
1966-01-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB832/67A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Czech Academy of Sciences CAS
Original Assignee
Czech Academy of Sciences CAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1966-01-06
Filing date
1967-01-06
Publication date
1968-12-11
1967-01-06
Application filed by Czech Academy of Sciences CAS
filed
Critical
Czech Academy of Sciences CAS
1968-12-11
Publication of GB1135966A
publication
Critical
patent/GB1135966A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K9/00—Medicinal preparations characterised by special physical form
A61K9/20—Pills, tablets, discs, rods
A61K9/2004—Excipients; Inactive ingredients
A61K9/2022—Organic macromolecular compounds
A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
C—CHEMISTRY; METALLURGY
C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
C08F36/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, at least one having two or more carbon-to-carbon double bonds
C08F36/02—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, at least one having two or more carbon-to-carbon double bonds the radical having only two carbon-to-carbon double bonds
C08F36/20—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, at least one having two or more carbon-to-carbon double bonds the radical having only two carbon-to-carbon double bonds unconjugated
Abstract
1,135,966. Sustained-release medicaments. CESKOSLOVENSKA AKADEMIE VED. 6 Jan., 1967 [6 Jan., 1966; 9 Jan., 1966], No. 832/67. Headings A5B and A5R. Pharmaceutical preparations for the sustained administration of a medicament to a living organism in direct contact therewith comprise a hydrogel of a polymer which is insoluble but swellable in the fluids of the living organism and which is prepared by copolymerising a hydrophilic mono-olefinic monomer with 0.1 to 5% of a cross-linking agent which surrounds, or in which is incorporated, a soluble biologically active substance which is diffusible through the hydrogel. Forms of preparation mentioned include inplants, prostheses, granules, and delayed release forms (in which the polymer may be an ionexchanger which binds the medicament). Suitable polymers are those derived from such monomers as ethylene glycol monomethacrylate, ethylene glycol monoacrylate, their polyethylene glycol and poly-ethylene glycol/ propylene glycol analogues, methacrylamide, acrylamide, maleic acid anhydride, methacrylic acid, acrylic acid, alkali metal ethylene sulphonate and mixtures thereof. Numerous types of medicament are mentioned, specific examples relating to preparations comprising chloramphenical (microporous sponge for treating burns). 1-γ-oxabutyl-2,5-dioxo-3,4-diphenyl pyrazolidine (implant tablets), tetracycline hydrochloride (sponge), hormones e.g. dihydrocortisone and ovarial or androgenic hormones and 6-azauridine (films) and oxytetracycline (implant).
GB832/67A
1966-01-06
1967-01-06
Improvements in or relating to sustained-release medicaments
Expired
GB1135966A
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
CS8366
1966-01-06
CS83866
1966-02-09
Publications (1)
Publication Number
Publication Date
GB1135966A
true
GB1135966A
(en)
1968-12-11
Family
ID=25745236
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB832/67A
Expired
GB1135966A
(en)
1966-01-06
1967-01-06
Improvements in or relating to sustained-release medicaments
Country Status (7)
Country
Link
US
(2)
US3551556A
(en)
AU
(1)
AU411053B2
(en)
DE
(1)
DE1617393C2
(en)
ES
(1)
ES335314A1
(en)
FR
(1)
FR1586811A
(en)
GB
(1)
GB1135966A
(en)
IT
(1)
IT1050353B
(en)
Cited By (10)
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Publication number
Priority date
Publication date
Assignee
Title
FR2052973A1
(en)
*
1969-06-16
1971-04-16
Reese Hospital Michael
FR2187290A1
(en)
*
1972-06-09
1974-01-18
Purdue Research Foundation
FR2355510A1
(en)
*
1976-06-21
1978-01-20
Toko Yakuhin Kogyo Kk
PROCESS FOR THE PRODUCTION OF PHARMACEUTICAL COMPOSITIONS CONTAINING A MIXTURE OF AQUEOUS SOLUTION OF CARBOXYVINYL POLYMER WITH A BASIC COMPOUND
US4202880A
(en)
1976-12-13
1980-05-13
Imperial Chemical Industries Limited
Delivery means for biologically active agents comprising hydrophilic polyurethane
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(en)
1976-12-13
1980-11-25
Imperial Chemical Industries Limited
Delivery means for biologically active agents
US4296097A
(en)
*
1979-02-27
1981-10-20
Lee Weng Y
Suppression of reaginic antibodies to drugs employing polyvinyl alcohol as carrier therefor
US4430260A
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1979-02-27
1984-02-07
Lee Weng Y
Penicillin-polyvinyl alcohol conjugate and process of preparation
GB2181053A
(en)
*
1985-10-01
1987-04-15
Sandoz Ltd
Controlled release formulation
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*
1979-03-21
1990-01-16
National Research Development Corporation
Controlled release compositions
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1989-02-16
1994-08-30
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Dispensing device
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Title
DE1617393C2
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1966-01-06
1982-11-11
Československá akademie věd, Praha
Process for the preparation of hydrophilic crosslinked copolymers containing biologically active substances
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1968-03-06
1975-05-20
Ceskoslovenska Akademie Ved
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1968-04-22
1975-01-14
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1970-09-09
1974-12-31
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1970-09-29
1973-01-16
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1971-06-04
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1971-09-30
1973-01-15
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1972-12-27
1974-05-21
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1973-03-28
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1973-05-04
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1973-09-10
1975-09-09
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1973-09-10
1975-10-07
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1973-09-10
1975-08-26
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Sustained release of methantheline
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1973-09-10
1975-08-26
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1973-09-10
1979-12-11
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1973-09-10
1977-02-08
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1973-09-10
1975-08-26
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1973-09-10
1975-08-26
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1975-08-26
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Population Research, Inc.
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1977-07-20
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1978-10-20
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1979-09-10
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1979-12-05
1986-11-17
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DEVICE FOR SUPPLYING MEDICALLY ACTIVE SUBSTANCES TO PROMOTE ABORTION
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1982-06-21
1984-04-17
Euroceltique, S.A.
Extended action controlled release compositions
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1983-03-02
1983-04-07
Graham N B
Hydrogel-containing envelopes
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1983-06-08
1985-11-19
Mattheus F.A. Goosen
Slow release injectable insulin composition
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1983-11-25
1984-01-04
Exxon Research Engineering Co
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Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use
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1985-05-20
1987-06-16
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Tablet granulation
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1985-08-16
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Bausch & Lomb Incorporated
Sustained-release formulation containing an amino acid polymer with a lower alkyl (C1 -C4) polar solvent
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1992-02-18
Rajan Bawa
Sustained-release formulation comprising a hydrophobic polymer system
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1985-08-16
1987-05-26
Bausch & Lomb Incorporated
Sustained-release formulation containing and amino acid polymer
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1985-11-22
1987-06-04
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Ointment base
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1986-05-09
1991-01-22
Alza Corporation
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1986-05-09
1993-04-06
Alza Corporation
Improvement in pulsed drug therapy
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1986-05-09
1990-08-14
Alza Corporation
Pulsed drug delivery
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1986-05-16
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Victoria State
Biocompatible implants.
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1986-05-22
1990-09-25
Syntex (U.S.A.) Inc.
Delayed/sustained release of macromolecules
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1986-07-07
1989-08-08
Dow Corning Corporation
Lattice-entrapped composition
US4837030A
(en)
*
1987-10-06
1989-06-06
American Cyanamid Company
Novel controlled release formulations of tetracycline compounds
US5277915A
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*
1987-10-30
1994-01-11
Fmc Corporation
Gel-in-matrix containing a fractured hydrogel
US4931282A
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*
1987-11-25
1990-06-05
Minnesota Mining And Manufacturing Company
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Family Cites Families (2)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US3220960A
(en)
*
1960-12-21
1965-11-30
Wichterle Otto
Cross-linked hydrophilic polymers and articles made therefrom
DE1617393C2
(en)
*
1966-01-06
1982-11-11
Československá akademie věd, Praha
Process for the preparation of hydrophilic crosslinked copolymers containing biologically active substances
1967
1967-01-05
DE
DE1617393A
patent/DE1617393C2/en
not_active
Expired
1967-01-05
FR
FR1586811D
patent/FR1586811A/fr
not_active
Expired
1967-01-05
IT
IT11212/67A
patent/IT1050353B/en
active
1967-01-05
ES
ES0335314A
patent/ES335314A1/en
not_active
Expired
1967-01-06
AU
AU16202/67A
patent/AU411053B2/en
not_active
Expired
1967-01-06
GB
GB832/67A
patent/GB1135966A/en
not_active
Expired
1967-01-06
US
US607637A
patent/US3551556A/en
not_active
Expired – Lifetime
1970
1970-09-23
US
US74905A
patent/US3689634A/en
not_active
Expired – Lifetime
Cited By (12)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
FR2052973A1
(en)
*
1969-06-16
1971-04-16
Reese Hospital Michael
FR2187290A1
(en)
*
1972-06-09
1974-01-18
Purdue Research Foundation
FR2355510A1
(en)
*
1976-06-21
1978-01-20
Toko Yakuhin Kogyo Kk
PROCESS FOR THE PRODUCTION OF PHARMACEUTICAL COMPOSITIONS CONTAINING A MIXTURE OF AQUEOUS SOLUTION OF CARBOXYVINYL POLYMER WITH A BASIC COMPOUND
US4202880A
(en)
1976-12-13
1980-05-13
Imperial Chemical Industries Limited
Delivery means for biologically active agents comprising hydrophilic polyurethane
US4235988A
(en)
1976-12-13
1980-11-25
Imperial Chemical Industries Limited
Delivery means for biologically active agents
US4296097A
(en)
*
1979-02-27
1981-10-20
Lee Weng Y
Suppression of reaginic antibodies to drugs employing polyvinyl alcohol as carrier therefor
US4430260A
(en)
1979-02-27
1984-02-07
Lee Weng Y
Penicillin-polyvinyl alcohol conjugate and process of preparation
US4894238A
(en)
*
1979-03-21
1990-01-16
National Research Development Corporation
Controlled release compositions
US4931288A
(en)
*
1979-03-21
1990-06-05
Lloyds Bank Plc
Controlled release compositions (II)
GB2181053A
(en)
*
1985-10-01
1987-04-15
Sandoz Ltd
Controlled release formulation
GB2181053B
(en)
*
1985-10-01
1990-05-23
Sandoz Ltd
Pharmaceutical formulations with controlled release of the active substance
US5342624A
(en)
*
1989-02-16
1994-08-30
British Technology Group Ltd.
Dispensing device
Also Published As
Publication number
Publication date
US3689634A
(en)
1972-09-05
AU1620267A
(en)
1968-07-11
FR1586811A
(en)
1970-03-06
IT1050353B
(en)
1981-03-10
ES335314A1
(en)
1967-12-01
US3551556A
(en)
1970-12-29
DE1617393A1
(en)
1971-03-18
AU411053B2
(en)
1971-03-01
DE1617393C2
(en)
1982-11-11
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