GB1137796A

GB1137796A – New substituted benzo-1,4-oxazines products, their use and methods of manufacture
– Google Patents

GB1137796A – New substituted benzo-1,4-oxazines products, their use and methods of manufacture
– Google Patents
New substituted benzo-1,4-oxazines products, their use and methods of manufacture

Info

Publication number
GB1137796A

GB1137796A
GB3576167A
GB3576167A
GB1137796A
GB 1137796 A
GB1137796 A
GB 1137796A
GB 3576167 A
GB3576167 A
GB 3576167A
GB 3576167 A
GB3576167 A
GB 3576167A
GB 1137796 A
GB1137796 A
GB 1137796A
Authority
GB
United Kingdom
Prior art keywords
benzoxazine
dihydro
substituted
phenyl
alkyl
Prior art date
1966-08-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB3576167A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Knoll GmbH

Original Assignee
Knoll GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1966-08-11
Filing date
1967-08-03
Publication date
1968-12-27

1967-08-03
Application filed by Knoll GmbH
filed
Critical
Knoll GmbH

1968-12-27
Publication of GB1137796A
publication
Critical
patent/GB1137796A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms

C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines

C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings

C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring

Abstract

1,137,796. Substituted 1,4-benzoxazines. KNOLL A.G. CHEMISCHE FABRIKEN. 3 Aug., 1967 [11 Aug., 1966], No. 35761/67. Heading C2C. Novel substituted 1,4-benzoxazines of the formula wherein R 1 is hydrogen, chlorine, methyl or methoxy, R 2 , R 3 and R 4 are each hydrogen, C 1-3 alkyl, phenyl or benzyl, R 5 and R 6 are each, when considered individually hydrogen, C 1-6 alkyl, C 1-6 cycloalkyl, a C 1-2 alkyl substituted by phenyl, in which the phenyl may be substituted by one or more methoxy groups, or R 5 and R 6 , considered together with the adjacent nitrogen atom form a piperidyl, pyrrolidyl, morpholyl or N1-methyl-pyrazinyl radical, and A is C 1-3 alkylene and their non-toxic, pharmaceutically acceptable acid addition salts are prepared by treating the N – haloacylated – 3,4 – dihydro-(2H)- 1,4-benzoxazine resulting from the reaction of the corresponding N-unsubstituted-3,4-dihydro- (2H)-1,4-benzoxazine with a compound of formula Hal-A-CO-Hal, with the appropriate amine of formula HN(R 5 )R 6 . 4-(Aminoacetyl) – 3,4 – dihydro – (2H) – 1,4 – benzoxazine is prepared by reacting 4-(phthalimido-acetyl)- 3,4 – dihydro – (2H) – 1,4 – benzoxazine, obtained by treating 3,4-dihydro-(2H)-1,4-benzoxazine with phthalimido-acetyl chloride, with a solution of hydrazine in ethanol. Therapeutic compositions, in the form of tablets, sugar-coated pills, capsules, ampoules, suppositories or drops, comprise the above novel compounds or their non-toxic pharmaceutically acceptable acid addition salts as the active ingredient. The compositions have analgetic and antipyretic activity.

GB3576167A
1966-08-11
1967-08-03
New substituted benzo-1,4-oxazines products, their use and methods of manufacture

Expired

GB1137796A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

DE1966K0060001

DE1595863C3
(en)

1966-08-11
1966-08-11

4-Piperidinoacetyl-3,4-dihydro- (2H) -1, 4-benioxazine and process for its preparation

Publications (1)

Publication Number
Publication Date

GB1137796A
true

GB1137796A
(en)

1968-12-27

Family
ID=7229402
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB3576167A
Expired

GB1137796A
(en)

1966-08-11
1967-08-03
New substituted benzo-1,4-oxazines products, their use and methods of manufacture

Country Status (4)

Country
Link

BE
(1)

BE702360A
(en)

DE
(1)

DE1595863C3
(en)

GB
(1)

GB1137796A
(en)

NL
(1)

NL6711108A
(en)

Cited By (7)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US4030906A
(en)

1974-09-27
1977-06-21
Chevron Research Company
Herbicidal N-haloacetyl-1,2-dihydro-4H-3,1-benzoxazine

EP0196570A1
(en)

*

1985-03-22
1986-10-08
Ube Industries, Ltd.
Benzoaxazine derivatives and herbicidal composition

EP0432893A2
(en)

*

1989-11-08
1991-06-19
Yamanouchi Pharmaceutical Co. Ltd.
Benzoxazine derivatives, their preparation and pharmaceutical compositions containing them

US5420126A
(en)

*

1989-11-08
1995-05-30
Yamanouchi Pharmaceutical Co., Ltd.
3,4-dihydro-2H-1,4-benzoxazine derivatives and pharmaceutical compositions containing the same

US5496815A
(en)

*

1990-02-08
1996-03-05
Tanabe Seiyaku Co., Ltd.
Thiazine (or oxazine) derivatives and preparation thereof

WO2015106025A1
(en)

2014-01-09
2015-07-16
The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone
Substituted benzoxazine and related compounds

WO2022087433A1
(en)

*

2020-10-23
2022-04-28
Dana-Farber Cancer Institute, Inc.
Covalent inhibitors of creatine kinase (ck) and uses thereof for treating and preventing cancer

Families Citing this family (2)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

MX159669A
(en)

*

1983-12-12
1989-08-02
Ciba Geigy Ag

PROCEDURE FOR THE PREPARATION OF ACILAMIDE DERIVATIVES

DE122009000062I2
(en)

*

1989-10-20
2011-01-13
Otsuka Pharma Co Ltd

BENZOHETEROCYCLIC COMPOUNDS

1966

1966-08-11
DE
DE1966K0060001
patent/DE1595863C3/en
not_active
Expired

1967

1967-08-03
GB
GB3576167A
patent/GB1137796A/en
not_active
Expired

1967-08-07
BE
BE702360D
patent/BE702360A/xx
unknown

1967-08-11
NL
NL6711108A
patent/NL6711108A/xx
unknown

Cited By (11)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US4030906A
(en)

1974-09-27
1977-06-21
Chevron Research Company
Herbicidal N-haloacetyl-1,2-dihydro-4H-3,1-benzoxazine

EP0196570A1
(en)

*

1985-03-22
1986-10-08
Ube Industries, Ltd.
Benzoaxazine derivatives and herbicidal composition

EP0432893A2
(en)

*

1989-11-08
1991-06-19
Yamanouchi Pharmaceutical Co. Ltd.
Benzoxazine derivatives, their preparation and pharmaceutical compositions containing them

EP0432893A3
(en)

*

1989-11-08
1991-07-10
Yamanouchi Pharmaceutical Co. Ltd.
Benzoxazine derivatives, their preparation and pharmaceutical compositions containing them

AU641953B2
(en)

*

1989-11-08
1993-10-07
Yamanouchi Pharmaceutical Co., Ltd.
Benzoxazine derivatives, pharmaceutical compositions containing them and processes for their production

US5420126A
(en)

*

1989-11-08
1995-05-30
Yamanouchi Pharmaceutical Co., Ltd.
3,4-dihydro-2H-1,4-benzoxazine derivatives and pharmaceutical compositions containing the same

US5496815A
(en)

*

1990-02-08
1996-03-05
Tanabe Seiyaku Co., Ltd.
Thiazine (or oxazine) derivatives and preparation thereof

WO2015106025A1
(en)

2014-01-09
2015-07-16
The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone
Substituted benzoxazine and related compounds

US10087151B2
(en)

2014-01-09
2018-10-02
The J. David Gladstone Institutes, A Testimentary Trust Established Under The Will Of J. David Gladstone
Substituted benzoxazine and related compounds

US10611741B2
(en)

2014-01-09
2020-04-07
The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone
Substituted benzoxazine and related compounds

WO2022087433A1
(en)

*

2020-10-23
2022-04-28
Dana-Farber Cancer Institute, Inc.
Covalent inhibitors of creatine kinase (ck) and uses thereof for treating and preventing cancer

Also Published As

Publication number
Publication date

DE1595863A1
(en)

1970-02-12

NL6711108A
(en)

1968-02-12

DE1595863C3
(en)

1978-03-02

BE702360A
(en)

1968-02-07

DE1595863B2
(en)

1977-07-14

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