GB1175456A – Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them
– Google Patents
GB1175456A – Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them
– Google Patents
Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them
Info
Publication number
GB1175456A
GB1175456A
GB05571/67A
GB1557167A
GB1175456A
GB 1175456 A
GB1175456 A
GB 1175456A
GB 05571/67 A
GB05571/67 A
GB 05571/67A
GB 1557167 A
GB1557167 A
GB 1557167A
GB 1175456 A
GB1175456 A
GB 1175456A
Authority
GB
United Kingdom
Prior art keywords
estra
trien
novel
april
ones
Prior art date
1966-01-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB05571/67A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1966-01-21
Filing date
1967-04-05
Publication date
1969-12-23
1967-04-05
Application filed by Roussel Uclaf SA
filed
Critical
Roussel Uclaf SA
1969-12-23
Publication of GB1175456A
publication
Critical
patent/GB1175456A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K31/00—Medicinal preparations containing organic active ingredients
A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K31/00—Medicinal preparations containing organic active ingredients
A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K31/00—Medicinal preparations containing organic active ingredients
A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07J—STEROIDS
C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07J—STEROIDS
C07J75/00—Processes for the preparation of steroids in general
Abstract
1,175,456. 13 – Alkyl – gona – 4,9,11 – trienes. ROUSSEL-UCLAF. 5 April, 1967 [5 April, 1966; 21 April, 1966; 13 May, 1966; 8 July, 1966; 1 Dec., 1966; 15 Feb., 1967], No. 15571/67. Heading C2U. Novel compounds of formula (wherein A is an oxo or ketal group, B is alkyl, D is H or optionally substituted alkyl, E is an optionally substituted hydrocarbon or heterocyclic radical), and derivatives thereof containing one or more additional nuclear substituents, are prepared by etherification of the corresponding 17#-ols. The compounds 17#-methoxy- 17α – methyl – estra – 4,9,11 – trien – 3 – one (see Specification 1,127,746) and 17#-tetrahydropyranyloxy – estra – 4,9,11 – trien – 3 – one (see Specification 1,099,006) are disclaimed. The 3- ketals of Formula I may be converted to the 3- ones by hydrolysis. The novel 3-ketals of 17#-hydroxy-estra-4,9, 11 – trien – 3 – one and of 17α – methyl – 17#- hydroxy – estra – 4,9,11 – trien – 3 – one are prepared by reduction of the corresponding 17- ones or by ketalization of the corresponding 3-ones. The compounds of Formula I are stated to possess anabolizing and androgenic activities and may be made up with suitable vehicles into pharmaceutical compositions which may be administered orally, parenterally, rectally or topically.
GB05571/67A
1966-01-21
1967-04-05
Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them
Expired
GB1175456A
(en)
Applications Claiming Priority (7)
Application Number
Priority Date
Filing Date
Title
FR46778
1966-01-21
FR56491A
FR5301M
(en)
1966-01-21
1966-04-05
FR58471A
FR5320M
(en)
1966-01-21
1966-04-21
FR61569A
FR5484M
(en)
1966-01-21
1966-05-13
FR68757A
FR1492985A
(en)
1966-01-21
1966-07-08
unsaturated steroid ethers and methods of preparation
FR85819A
FR6425M
(en)
1966-01-21
1966-12-01
FR95053A
FR6096M
(en)
1966-01-21
1967-02-15
Publications (1)
Publication Number
Publication Date
GB1175456A
true
GB1175456A
(en)
1969-12-23
Family
ID=27562279
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB05571/67A
Expired
GB1175456A
(en)
1966-01-21
1967-04-05
Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them
Country Status (10)
Country
Link
AT
(1)
AT280493B
(en)
BE
(1)
BE696084A
(en)
CH
(1)
CH474499A
(en)
DK
(1)
DK120949B
(en)
ES
(5)
ES338882A1
(en)
FR
(6)
FR5301M
(en)
GB
(1)
GB1175456A
(en)
IL
(1)
IL27745A
(en)
NL
(1)
NL6704829A
(en)
SE
(1)
SE320364B
(en)
Families Citing this family (3)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
FR2183555B1
(en)
*
1972-05-10
1975-06-20
Roussel Uclaf
FR2285138A1
(en)
*
1974-09-20
1976-04-16
Roussel Uclaf
NEW TRIENIC STEROID DERIVATIVE, ITS PREPARATION PROCESS AND ITS APPLICATION AS A MEDICINAL PRODUCT
FR2388560A1
(en)
*
1977-04-27
1978-11-24
Roussel Uclaf
NEW ZOOTECHNICAL COMPOSITIONS CONTAINING ON THE ONE HAND ZERANOL AND ON THE OTHER HAND A STEROID 4,9,11 TRIENIQUE
1966
1966-04-05
FR
FR56491A
patent/FR5301M/fr
not_active
Expired
1966-04-21
FR
FR58471A
patent/FR5320M/fr
not_active
Expired
1966-05-13
FR
FR61569A
patent/FR5484M/fr
not_active
Expired
1966-07-08
FR
FR68757A
patent/FR1492985A/en
not_active
Expired
1966-12-01
FR
FR85819A
patent/FR6425M/fr
not_active
Expired
1967
1967-02-15
FR
FR95053A
patent/FR6096M/fr
not_active
Expired
1967-03-24
BE
BE696084D
patent/BE696084A/xx
unknown
1967-03-30
DK
DK168367A
patent/DK120949B/en
unknown
1967-03-30
CH
CH446467A
patent/CH474499A/en
not_active
IP Right Cessation
1967-04-03
SE
SE461967A
patent/SE320364B/xx
unknown
1967-04-04
ES
ES338882A
patent/ES338882A1/en
not_active
Expired
1967-04-05
GB
GB05571/67A
patent/GB1175456A/en
not_active
Expired
1967-04-05
NL
NL6704829A
patent/NL6704829A/xx
unknown
1967-04-05
AT
AT326267A
patent/AT280493B/en
not_active
IP Right Cessation
1967-04-05
IL
IL2774567A
patent/IL27745A/en
unknown
1967-05-12
ES
ES340433A
patent/ES340433A1/en
not_active
Expired
1967-07-07
ES
ES342740A
patent/ES342740A1/en
not_active
Expired
1967-11-20
ES
ES347368A
patent/ES347368A1/en
not_active
Expired
1968
1968-02-14
ES
ES350471A
patent/ES350471A2/en
not_active
Expired
Also Published As
Publication number
Publication date
SE320364B
(en)
1970-02-09
FR5320M
(en)
1967-08-21
ES347368A1
(en)
1969-02-01
ES350471A2
(en)
1969-05-01
ES342740A1
(en)
1968-08-01
AT280493B
(en)
1970-04-10
ES340433A1
(en)
1968-06-01
BE696084A
(en)
1967-09-25
ES338882A1
(en)
1968-04-16
FR6425M
(en)
1968-11-04
CH474499A
(en)
1969-06-30
IL27745A
(en)
1974-10-22
FR5301M
(en)
1967-08-16
DK120949B
(en)
1971-08-09
FR5484M
(en)
1967-10-23
NL6704829A
(en)
1967-10-06
FR1492985A
(en)
1967-08-25
FR6096M
(en)
1968-06-10
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Legal Events
Date
Code
Title
Description
1970-05-06
PS
Patent sealed [section 19, patents act 1949]
1981-11-11
PCNP
Patent ceased through non-payment of renewal fee
