GB1199731A

GB1199731A – Basic Ketones and Derivatives
– Google Patents

GB1199731A – Basic Ketones and Derivatives
– Google Patents
Basic Ketones and Derivatives

Info

Publication number
GB1199731A

GB1199731A
GB1787966A
GB1787966A
GB1199731A
GB 1199731 A
GB1199731 A
GB 1199731A
GB 1787966 A
GB1787966 A
GB 1787966A
GB 1787966 A
GB1787966 A
GB 1787966A
GB 1199731 A
GB1199731 A
GB 1199731A
Authority
GB
United Kingdom
Prior art keywords
formula
compound
alkyl
reaction
compounds
Prior art date
1966-04-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB1787966A
Inventor
Minoo Dossabhoy Mehta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Beecham Group PLC

Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1966-04-23
Filing date
1966-04-23
Publication date
1970-07-22

1966-04-23
Application filed by Beecham Group PLC
filed
Critical
Beecham Group PLC

1966-04-23
Priority to GB1787966A
priority
Critical
patent/GB1199731A/en

1970-07-22
Publication of GB1199731A
publication
Critical
patent/GB1199731A/en

Status
Expired
legal-status
Critical
Current

Links

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Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates

C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms

C07C49/213—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings

C07C49/217—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the aromatic rings

C07C49/223—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the aromatic rings polycyclic

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds

C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups

C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton

C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms

C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups

C07C45/75—Reactions with formaldehyde

Abstract

1,199,731. Basic ketones and derivatives. BEECHAM GROUP Ltd. 24 July, 1967 [23 April, 1966], No. 17879/66. Heading C2C. Novel compounds of Formula I and acid addition salts thereof wherein R1 is H, OH, or alkoxy, Z and Y together represent an oxygen atom, R2 is H or alkyl and R3 is H, alkyl, cyclohexyl, phenylalkyl, dialkylaminoalkyl or hydroxyalkyl or R2 and R3 together with N represent a pyrrolidino, piperidino, morpholino, piperazino or 4-alkyl- or 4-hydroxyalkyl-piperazino group, are prepared either by reaction of a compound of formula wherein R4 # R1 above, with an amine of formula HNR2R3 and formaldehyde or by reaction of the above amine with a compound of formula When R1 is OH or alkoxy, the corresponding halo compound, where R1 is halogen, may be hydrolysed or reacted with an alcohol. The above novel compounds are converted into compounds of general Formula I above wherein X is H and Y is H, hydroxy or acyloxy by reduction of the keto group optionally followed by acylation. Also those which contain a secondary amino group may be acylated and those in which R1 is H may be halogenated to give compounds wherein R1 is halogen. 1,1 – Diphenyl – 3 – methylbut – 3 – en – 2 – one is isolated from the reaction of 1,1-diphenylbutan- 2-one formaldehyde and dimethylamine hydrochloride in dimethylformamide. Pharmaceutical compositions having anticonvulsant activity and in conventional forms for oral, parenteral or topical administration comprise an above novel compound and a carrier therefor.

GB1787966A
1966-04-23
1966-04-23
Basic Ketones and Derivatives

Expired

GB1199731A
(en)

Priority Applications (1)

Application Number
Priority Date
Filing Date
Title

GB1787966A

GB1199731A
(en)

1966-04-23
1966-04-23
Basic Ketones and Derivatives

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

GB1787966A

GB1199731A
(en)

1966-04-23
1966-04-23
Basic Ketones and Derivatives

Publications (1)

Publication Number
Publication Date

GB1199731A
true

GB1199731A
(en)

1970-07-22

Family
ID=10102826
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB1787966A
Expired

GB1199731A
(en)

1966-04-23
1966-04-23
Basic Ketones and Derivatives

Country Status (1)

Country
Link

GB
(1)

GB1199731A
(en)

Cited By (2)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

DE2408658A1
(en)

1973-02-24
1974-08-29
Beecham Group Ltd

DERIVATIVES OF 1,1-DIPHENYL-2-HYDROXY3-AMINOPROPANE, THE METHOD FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THESE DERIVATIVES

DE2328758A1
(en)

*

1973-06-06
1975-01-09
Basf Ag
4,4-Diphenyl-2-methyl-2-hydroxy-butyl-amines – from 2-(2′,2′-diphenyl ethyl)-2-methyloxirane and suitable amines

1966

1966-04-23
GB
GB1787966A
patent/GB1199731A/en
not_active
Expired

Cited By (3)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

DE2408658A1
(en)

1973-02-24
1974-08-29
Beecham Group Ltd

DERIVATIVES OF 1,1-DIPHENYL-2-HYDROXY3-AMINOPROPANE, THE METHOD FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THESE DERIVATIVES

DE2463157A1
(en)

*

1973-02-24
1982-09-16

DE2328758A1
(en)

*

1973-06-06
1975-01-09
Basf Ag
4,4-Diphenyl-2-methyl-2-hydroxy-butyl-amines – from 2-(2′,2′-diphenyl ethyl)-2-methyloxirane and suitable amines

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Legal Events

Date
Code
Title
Description

1970-12-02
PS
Patent sealed

1976-02-25
PLNP
Patent lapsed through nonpayment of renewal fees

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