GB1221855A

GB1221855A – Penicillin and cephalosporin derivatives
– Google Patents

GB1221855A – Penicillin and cephalosporin derivatives
– Google Patents
Penicillin and cephalosporin derivatives

Info

Publication number
GB1221855A

GB1221855A
GB07284/68A
GB1728468A
GB1221855A
GB 1221855 A
GB1221855 A
GB 1221855A
GB 07284/68 A
GB07284/68 A
GB 07284/68A
GB 1728468 A
GB1728468 A
GB 1728468A
GB 1221855 A
GB1221855 A
GB 1221855A
Authority
GB
United Kingdom
Prior art keywords
alkyl
amino
monocyclic aryl
acid
aryl
Prior art date
1967-04-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB07284/68A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

ER Squibb and Sons LLC

Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1967-04-27
Filing date
1968-04-10
Publication date
1971-02-10

1968-04-10
Application filed by ER Squibb and Sons LLC
filed
Critical
ER Squibb and Sons LLC

1971-02-10
Publication of GB1221855A
publication
Critical
patent/GB1221855A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Abstract

1,221,855. Penicillins; cephalosporins. E. R. SQUIBB & SONS Inc. 10 April, 1968 [27 April, 1967], No. 17284/68. Heading C2A. [Also in Division A5] The invention comprises alkyl and aryl sulphinyl penicillins and cephalosporins of Formula I wherein R1 is either or wherein A is the acyloxy of a hydrocarbon carboxylic acid of less than 12 carbon atoms, a quaternary ammonium radical, amino C 1 to C 7 alkyl amino, di (C 1-7 alkyl) amino, monocyclic aryl C 1 -C 7 alkylamino, heterocyclic tertiary amino or when taken together with M, is a monovalent -C-O- bond; and M is H, a pharmaceutically acceptable non-toxic cation, an anionic charge when A is a quaternary ammonium radical, or when taken together with A is a monovalent -C-O- bond; and wherein R2 is wherein R3 is C 1 to C 7 alkyl, monocyclic aryl or monocyclic aryl C 1 to C 7 alkyl; R4 and R5 are each H, C 1 -C 7 alkyl, monocyclic aryl or monocyclic aryl C 1 -C 7 alkyl; and n is 1, 2 or 3 and the grouping may be the same or different. Typical compounds are 7 – [3 – (methylsulphinyl) propionamido] cephalosporanic acid, 7 – [3 – (benzylsulphinyl) propionamido] penicillanic acid and 7 – [3 – (methylsulphinyl) propionamido] – 3 – (1 – pyridinium methyl) – ceph – 3 – em – 4 – carboxylate. The compounds are prepared by the acylation of 7 – aminocephalosporanic acid or 6 – amino penicillanic acid with an alkyl or aryl sulphinylcarboxylic acid derivative of formula wherein R3, R4 and R5 and n are as set forth above and B is OH, halogen, azide, p-nitrophenoxy or mixed anhydride. The preparation of salts and conversions at the 3-position of the cephalosporin may be carried out in a conventional manner. The antibiotics are antibacterials for medical and general disinfectant use and may be used as animal feed supplements. Pharmaceutical compositions for oral and parenteral use, e.g. tablets, capsules and injections, comprise as active ingredient a penicillin or cephalosporin of Formula I above. The compounds may be added to animal feeds.

GB07284/68A
1967-04-27
1968-04-10
Penicillin and cephalosporin derivatives

Expired

GB1221855A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

US634115A

US3382238A
(en)

1967-04-27
1967-04-27
Penicillin and cephalosporin derivatives

Publications (1)

Publication Number
Publication Date

GB1221855A
true

GB1221855A
(en)

1971-02-10

Family
ID=24542498
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB07284/68A
Expired

GB1221855A
(en)

1967-04-27
1968-04-10
Penicillin and cephalosporin derivatives

Country Status (4)

Country
Link

US
(1)

US3382238A
(en)

DE
(1)

DE1770234A1
(en)

FR
(2)

FR7482M
(en)

GB
(1)

GB1221855A
(en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

GB1277578A
(en)

*

1968-07-04
1972-06-14
Pharmacia As
Penicillins

US3920638A
(en)

*

1968-08-20
1975-11-18
Ciba Geigy Corp
Process for preparation of 7-amino-cephalosporanic acid compound

US3891763A
(en)

*

1968-09-28
1975-06-24
Takeda Chemical Industries Ltd
Synthetic penicillins

US3499893A
(en)

*

1968-12-06
1970-03-10
Bristol Myers Co
Pyrimidinyl- or diazepinylthioacetamidocephalosporanic acids

US3499885A
(en)

*

1968-12-06
1970-03-10
Bristol Myers Co
Pyrimidinyl- or diazepinyl-thioacetamidopenicillanic acids

US4029656A
(en)

*

1970-02-11
1977-06-14
Takeda Chemical Industries, Ltd.
7-(α-SULFOACYLAMIDO) CEPHALOSPORANIC ACIDS

US3988327A
(en)

*

1970-02-11
1976-10-26
Takeda Chemical Industries, Ltd.
7-(α-SULFOACYLAMIDO)CEPHALOSPORANIC ACIDS

US4065619A
(en)

*

1971-07-17
1977-12-27
Takeda Chemical Industries, Ltd.
7-(α-Sulfoacylamido)cephalosporins

US4160830A
(en)

*

1971-07-17
1979-07-10
Takeda Chemical Industries, Ltd.
Cephalosporins

US3923799A
(en)

*

1972-05-03
1975-12-02
Smithkline Corp
Substituted sulfonylacetamido cephalosporins

US3925373A
(en)

*

1972-05-03
1975-12-09
Smithkline Corp
Substituted sulfonylacetamido cephalosporins

US3928338A
(en)

*

1972-05-03
1975-12-23
Smithkline Corp
Substituted sulfonylacetamido cephalosporins

US3960852A
(en)

*

1972-05-03
1976-06-01
Marinis Robert M De
Substituted sulfonylacetamido cephalosporins

US3922267A
(en)

*

1972-05-03
1975-11-25
Smithkline Corp
Substituted sulfonylacetamido cephalosporins

US3939266A
(en)

*

1972-05-03
1976-02-17
Smithkline Corporation
Substituted sulfonylacetamido cephalosporins

US3960853A
(en)

*

1972-05-03
1976-06-01
Smithkline Corporation
Substituted sulfonylacetamido cephalosporins

US3948905A
(en)

*

1972-05-03
1976-04-06
Smithkline Corporation
Substituted sulfonylacetamido cephalosporins

US3960855A
(en)

*

1972-05-03
1976-06-01
Smithkline Corporation
Substituted sulfonylacetamido cephalosporins

US3943127A
(en)

*

1973-06-18
1976-03-09
Smithkline Corporation
7-Trifluoromethylsulfinylacetamido cephalosporins

US3943128A
(en)

*

1973-06-18
1976-03-09
Smithkline Corporation
7-Trifluoromethylsulfinylacetamido cephalosporins

US3963711A
(en)

*

1973-08-17
1976-06-15
Smithkline Corporation
Cyanomethyl sulfinyl- and sulfonyl-acetamido cephalosporins

US3963709A
(en)

*

1973-08-17
1976-06-15
Smithkline Corporation
Cyanomethyl sulfinyl- and sulfonyl-acetamido cephalosporins

US3998819A
(en)

*

1973-12-26
1976-12-21
Smithkline Corporation
Trifluoroethyl-mercapto, -sulfinyl or -sulfonyl acetamidocephalosporins

US3998818A
(en)

*

1973-12-26
1976-12-21
Smithkline Corporation
Trifluoroethylmercapto, -sulfinyl or -sulfonyl acetamidocephalosporins

GB1527109A
(en)

*

1974-12-28
1978-10-04
Asahi Chemical Ind
Cephalosporin derivatives and process for preparing same

US4075338A
(en)

*

1975-12-29
1978-02-21
Smithkline Corporation
Substituted acetamidocephalosporins

US4229573A
(en)

*

1977-06-21
1980-10-21
Asahi Kasei Kogyo Kabushiki Kaisha
7α-Methoxycephalosporin derivatives

US5721064A
(en)

*

1993-04-30
1998-02-24
Aer Energy Resources Inc.
Air manager system for reducing gas concentrations in a metal-air battery

US6106962A
(en)

1997-09-24
2000-08-22
Aer Energy Resources Inc.
Air manager control using cell voltage as auto-reference

Family Cites Families (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US3335136A
(en)

*

1965-12-27
1967-08-08
Lilly Co Eli
Halophenylmercaptomethyl cephalosporins

1967

1967-04-27
US
US634115A
patent/US3382238A/en
not_active
Expired – Lifetime

1968

1968-04-10
GB
GB07284/68A
patent/GB1221855A/en
not_active
Expired

1968-04-19
DE
DE19681770234
patent/DE1770234A1/en
active
Pending

1968-04-24
FR
FR149257A
patent/FR7482M/fr
not_active
Expired

1968-04-24
FR
FR1586855D
patent/FR1586855A/fr
not_active
Expired

Also Published As

Publication number
Publication date

FR7482M
(en)

1969-12-01

DE1770234A1
(en)

1971-10-07

US3382238A
(en)

1968-05-07

FR1586855A
(en)

1970-03-06

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Penicillin composition

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(en)

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