GB1231472A

GB1231472A – – Google Patents

GB1231472A – – Google Patents

Info

Publication number
GB1231472A

GB1231472A

GB1231472DA
GB1231472A
GB 1231472 A
GB1231472 A
GB 1231472A

GB 1231472D A
GB1231472D A
GB 1231472DA
GB 1231472 A
GB1231472 A
GB 1231472A
Authority
GB
United Kingdom
Prior art keywords
oxo
androstane
acetoxy
oxa
compounds
Prior art date
1967-05-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1967-05-24
Filing date
1968-05-21
Publication date
1971-05-12

1968-05-21
Application filed
filed
Critical

1971-05-12
Publication of GB1231472A
publication
Critical
patent/GB1231472A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07J—STEROIDS

C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms

C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom

C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07J—STEROIDS

C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane

C07J1/0003—Androstane derivatives

C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa

C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified

C07J1/0025—Esters

Abstract

1,231,472. 1 – Azidomethyl – 2 – oxa – steroids. CIBA GEIGY A.G. 21 May, 1968 [24 May. 1967], No. 24178/68. Headings C2C and C2U, Novel 1 – azidomethyl – 3 – oxo – 2 – oxasteroids of the 5α- or 5#-androstane series which contain in the 17-position a free or functionally converted hydroxyl or oxo group are prepared by treatment with metal azides of reactive esters of the corresponding 1-hydroxymethyl compounds. Suitable reactive esters are the 1-halomethyl and 1-aliphatic- or -aryl-sulphonyloxymethyl compounds. In the products a functionally converted hydroxyl or oxo group may be liberated or a free hydroxy or oxo group functionally converted, e.g. esterified, etherified or ketalized. 1# – Mesyloxymethyl – 3 – oxo – 17# – acetoxy- 2-oxa-5α,-androstane is prepared by hydroxylating #1 – 3 – oxo – 17# – acetoxy – 5α – androstane using OsO 4 to give 1α-2α-dihydroxy- 3 – oxo – 17# – acetoxy – 5α – androstane, irradiating this with ultra-violet light to give 1# – hydroxymethyl – 3 – oxo – 17# – acetoxy – 2 – oxa-5α-androstane and mesylating this. The novel compounds are stated to possess antagonistic activity towards testosterone and may be made up with carriers into pharmaceutical compositions for oral, parenteral and topical administration.

GB1231472D
1967-05-24
1968-05-21

Expired

GB1231472A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

CH734767A

CH525908A
(en)

1967-05-24
1967-05-24

Process for the preparation of 1-azidomethyl-2-oxasteroids

Publications (1)

Publication Number
Publication Date

GB1231472A
true

GB1231472A
(en)

1971-05-12

Family
ID=4323699
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB1231472D
Expired

GB1231472A
(en)

1967-05-24
1968-05-21

Country Status (7)

Country
Link

US
(1)

US3542813A
(en)

BE
(1)

BE715573A
(en)

CH
(1)

CH525908A
(en)

DE
(1)

DE1768440A1
(en)

FR
(3)

FR1588494A
(en)

GB
(1)

GB1231472A
(en)

NL
(1)

NL6807277A
(en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US4366089A
(en)

*

1981-05-06
1982-12-28
General Electric Company
Calcium-nickel phosphate catalyst

Family Cites Families (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US3246014A
(en)

*

1964-02-27
1966-04-12
Searle & Co
Optionally 6-methylated 17alpha-alkynyl-17beta-oxygenated-2-oxa-5alpha-androstan-3-ones, 19-nor compounds corresponding, and delta4 and delta5(10) derivatives thereof

1967

1967-05-24
CH
CH734767A
patent/CH525908A/en
not_active
IP Right Cessation

1968

1968-05-15
DE
DE19681768440
patent/DE1768440A1/en
active
Pending

1968-05-17
US
US729941A
patent/US3542813A/en
not_active
Expired – Lifetime

1968-05-21
GB
GB1231472D
patent/GB1231472A/en
not_active
Expired

1968-05-22
BE
BE715573D
patent/BE715573A/xx
unknown

1968-05-22
NL
NL6807277A
patent/NL6807277A/xx
unknown

1968-05-24
FR
FR1588494D
patent/FR1588494A/fr
not_active
Expired

1968-08-22
FR
FR163773A
patent/FR7709M/fr
not_active
Expired

1968-08-22
FR
FR163772A
patent/FR7730M/fr
not_active
Expired

Also Published As

Publication number
Publication date

FR7709M
(en)

1970-02-23

CH525908A
(en)

1972-07-31

NL6807277A
(en)

1968-11-25

BE715573A
(en)

1968-11-22

FR7730M
(en)

1970-03-09

DE1768440A1
(en)

1971-07-15

FR1588494A
(en)

1970-04-17

US3542813A
(en)

1970-11-24

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(en)

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(en)

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(en)

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(en)

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(en)

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(en)

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ES375060A1
(en)

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21-esters of triamcinolone and triamcinolone acetonide and a method of preparing them

Legal Events

Date
Code
Title
Description

1971-09-22
PS
Patent sealed [section 19, patents act 1949]

1974-12-18
PLNP
Patent lapsed through nonpayment of renewal fees

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