GB1237268A – Proteinaceous reagent and process for producing same
– Google Patents
GB1237268A – Proteinaceous reagent and process for producing same
– Google Patents
Proteinaceous reagent and process for producing same
Info
Publication number
GB1237268A
GB1237268A
GB48249/68A
GB4824968A
GB1237268A
GB 1237268 A
GB1237268 A
GB 1237268A
GB 48249/68 A
GB48249/68 A
GB 48249/68A
GB 4824968 A
GB4824968 A
GB 4824968A
GB 1237268 A
GB1237268 A
GB 1237268A
Authority
GB
United Kingdom
Prior art keywords
reagent
compound
proteinaceous
protein
exemplified
Prior art date
1967-11-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB48249/68A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1967-11-01
Filing date
1968-10-11
Publication date
1971-06-30
1968-10-11
Application filed by Miles Laboratories Inc
filed
Critical
Miles Laboratories Inc
1971-06-30
Publication of GB1237268A
publication
Critical
patent/GB1237268A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
G—PHYSICS
G01—MEASURING; TESTING
G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 – G01N31/00
G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
C—CHEMISTRY; METALLURGY
C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
C12N11/06—Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
C—CHEMISTRY; METALLURGY
C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
C12N11/16—Enzymes or microbial cells immobilised on or in a biological cell
Abstract
1,237,268. Proteinaceous reagent. MILES LABORATORIES Inc. 11 Oct., 1968 [1 Nov., 1967], No. 48249/68. Heading B1X. [Also in Divisions C3 and C6] A proteinaceous reagent is prepared by a process comprising (a) treating an antigen, antibody or enzyme with either (i) a bis-diazotised aromatic compound capable of coupling with protein, or (ii) a linking compound (defined below), (b) treating protein-surfaced insoluble particles with whichever of compounds (i) or (ii) is not used in step (a), and (c) reacting the two treated materials together so that the unreacted diazo groups of compound (i) couple with the linking compound (ii) to form the proteinaceous reagent. Compound (i) may be bis-diazotised benzidine, dianisidine, or 4, 4′, diphenylamine. The linking compound (ii) is a compound reactive with proteinaceous material and containing an aromatic radical which is more susceptible to electrophilic substitution than any aromatic material occurring in protein. Compounds (ii) exemplified are pyrrole-2-carboxylic acid azide, thiophene-2-carboxylic acid azide, 2-furoic acid with N-ethyl-5-phenylisoxazolium-3′- sulphonate (Woodward’s reagent K) as activator, 2-thiophenesulphonyl chloride; others are mentioned. The protein-surfaced insoluble particles may be red blood cells (opossum, rat, rabbit, guinea pig, human, goat, sheep, chicken, alligator, turtle), microbial cells (preferably Brucella abortus, Escherichia coli (exemplified), Bacillus substilis, Bacillus pumilis, Lactobacillus kichmannii, Pseudomonas fragi, or Saccharonyees cerevisiae), or 0.1 to 10 microns size particles of for example polystyrene coated with gelatin. Antigens &c exemplified are myoglobin, HCG, haemoglobin, BSA, bovine gamma globulin, insulin; others are mentioned. Unit pack capsules may be prepared each carrying in different areas the lyophilized residues of a drop of a suspension of the reagent and of a dilution of the appropriate antiserum.
GB48249/68A
1967-11-01
1968-10-11
Proteinaceous reagent and process for producing same
Expired
GB1237268A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
US67962867A
1967-11-01
1967-11-01
Publications (1)
Publication Number
Publication Date
GB1237268A
true
GB1237268A
(en)
1971-06-30
Family
ID=24727678
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB48249/68A
Expired
GB1237268A
(en)
1967-11-01
1968-10-11
Proteinaceous reagent and process for producing same
Country Status (6)
Country
Link
DE
(1)
DE1806418A1
(en)
ES
(1)
ES359805A1
(en)
FR
(1)
FR1590466A
(en)
GB
(1)
GB1237268A
(en)
IL
(1)
IL30997A
(en)
NL
(1)
NL6815548A
(en)
Cited By (2)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
EP0023431A1
(en)
*
1979-07-30
1981-02-04
Brocades (Great Britain) Limited
Processes for the production of carrier particles from yeast cells and for producing diagnostic reagents therefrom; carrier particles and diagnostic reagent produced thereby and test kit containing such reagents
WO2006063592A1
(en)
*
2004-12-14
2006-06-22
Alk Abelló A/S
Pharmaceutical composition comprising a bacterial cell displaying a heterologous proteinaceous compound
Families Citing this family (4)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US4166767A
(en)
*
1976-03-25
1979-09-04
Dainippon Pharmaceutical Co., Ltd.
Insolubilized antibody
CH628738A5
(en)
*
1977-08-03
1982-03-15
Hoffmann La Roche
IMMUNOLOGICAL DIAGNOSTIC REAGENT.
EP0015473A1
(en)
*
1979-02-28
1980-09-17
F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft
Process for immobilizing cells
US4452886A
(en)
*
1981-09-21
1984-06-05
Henry Robert P
Novel photon absorbing or emitting polymers and their use as reagents in immunoassay systems
1968
1968-10-11
GB
GB48249/68A
patent/GB1237268A/en
not_active
Expired
1968-10-31
NL
NL6815548A
patent/NL6815548A/xx
unknown
1968-10-31
ES
ES359805A
patent/ES359805A1/en
not_active
Expired
1968-10-31
DE
DE19681806418
patent/DE1806418A1/en
active
Pending
1968-10-31
FR
FR1590466D
patent/FR1590466A/fr
not_active
Expired
1968-11-01
IL
IL30997A
patent/IL30997A/en
unknown
Cited By (2)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
EP0023431A1
(en)
*
1979-07-30
1981-02-04
Brocades (Great Britain) Limited
Processes for the production of carrier particles from yeast cells and for producing diagnostic reagents therefrom; carrier particles and diagnostic reagent produced thereby and test kit containing such reagents
WO2006063592A1
(en)
*
2004-12-14
2006-06-22
Alk Abelló A/S
Pharmaceutical composition comprising a bacterial cell displaying a heterologous proteinaceous compound
Also Published As
Publication number
Publication date
ES359805A1
(en)
1970-06-16
FR1590466A
(en)
1970-04-13
IL30997A
(en)
1973-03-30
DE1806418A1
(en)
1969-06-26
IL30997A0
(en)
1969-01-29
NL6815548A
(en)
1969-05-05
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