GB1237635A – Dibenzocycloheptene derivatives and a process for the manufacture thereof
– Google Patents
GB1237635A – Dibenzocycloheptene derivatives and a process for the manufacture thereof
– Google Patents
Dibenzocycloheptene derivatives and a process for the manufacture thereof
Info
Publication number
GB1237635A
GB1237635A
GB06454/69A
GB1645469A
GB1237635A
GB 1237635 A
GB1237635 A
GB 1237635A
GB 06454/69 A
GB06454/69 A
GB 06454/69A
GB 1645469 A
GB1645469 A
GB 1645469A
GB 1237635 A
GB1237635 A
GB 1237635A
Authority
GB
United Kingdom
Prior art keywords
dibenzo
dihydro
general formula
cycloheptenes
piperidylmethyl
Prior art date
1968-04-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB06454/69A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1968-04-02
Filing date
1969-03-28
Publication date
1971-06-30
1969-03-28
Application filed by F Hoffmann La Roche AG
filed
Critical
F Hoffmann La Roche AG
1971-06-30
Publication of GB1237635A
publication
Critical
patent/GB1237635A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
C07D211/12—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with only hydrogen atoms attached to the ring nitrogen atom
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
C07D213/30—Oxygen atoms
Abstract
1,237,635. 10,11 – Dihydro – 5 – (4 – piperidylmethyl) – 5H – dibenzo[a,d]cycloheptenes. F. HOFFMANN-LA ROCHE & CO. A.G. 28 March, 1969 [2 April, 1968], No. 16454/69. Heading C2C. Novel 10,11 – dihydro – 5 – (4 – piperidylmethyl) – 5H – dibenzo[a,d]cycloheptenes of the general formula wherein R and R 1 are each a hydrogen or halogen atom or a C 1-7 alkyl, C 1-7 alkoxy, trifluoromethyl or C 1-7 alkylsulphamoyl group, and R 2 and R 3 are each a hydrogen atom or a C 1-7 alkyl group, and pharmaceutically acceptable acid addition salts thereof are prepared by hydrogenation of a 10,11-dihydro-5-(4-pyridylmethylene)-5H-dibenzo[a,d]cycloheptene of the general formula or a C 1-7 alkyl quaternary derivative thereof, followed by optional alkylation of an N- unsubstituted compound thus obtained with a C 1-7 alkylating agent and/or optional salification of the product. 10,11 – Dihydro – 5 – (4 – pyridylmethylene)- 5H-dibenzo[a,d]cycloheptenes of the second general formula above are prepared by reaction of a 4-picolyl metal compound and a 10,11-dihydro- 5H – dibenzo[a,d]cyclohepten-5-one of the respective general formulµ wherein M is an alkali metal, and hydrolysis of the product and dehydration of the resulting 10,11 – dihydro – 5 – (4 – pyridylmethyl) – 5H – dibenzo[a,d]cyclohepten-5-ol of the general formula Pharmaceutical compositions having psychostimulant and antihistaminic activity comprise, as active ingredient, a 10,11-dihydro-5-(4- piperidylmethyl) – 5H – dibenzo[a,d]cycloheptene of the first general formula above or a pharmaceutically acceptable acid addition salt thereof, in association with a compatible pharmaceutical carrier, and may be administered orally, parenterally or rectally.
GB06454/69A
1968-04-02
1969-03-28
Dibenzocycloheptene derivatives and a process for the manufacture thereof
Expired
GB1237635A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
US71822968A
1968-04-02
1968-04-02
Publications (1)
Publication Number
Publication Date
GB1237635A
true
GB1237635A
(en)
1971-06-30
Family
ID=24885305
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB06454/69A
Expired
GB1237635A
(en)
1968-04-02
1969-03-28
Dibenzocycloheptene derivatives and a process for the manufacture thereof
Country Status (6)
Country
Link
BE
(1)
BE730847A
(en)
DE
(1)
DE1916750A1
(en)
FR
(1)
FR2007365A1
(en)
GB
(1)
GB1237635A
(en)
IL
(1)
IL31761A0
(en)
NL
(1)
NL6905119A
(en)
1969
1969-03-09
IL
IL31761A
patent/IL31761A0/en
unknown
1969-03-28
GB
GB06454/69A
patent/GB1237635A/en
not_active
Expired
1969-04-01
DE
DE19691916750
patent/DE1916750A1/en
active
Pending
1969-04-01
BE
BE730847D
patent/BE730847A/xx
unknown
1969-04-01
FR
FR6909840A
patent/FR2007365A1/en
active
Pending
1969-04-02
NL
NL6905119A
patent/NL6905119A/xx
unknown
Also Published As
Publication number
Publication date
BE730847A
(en)
1969-10-01
DE1916750A1
(en)
1969-11-06
NL6905119A
(en)
1969-10-06
FR2007365A1
(en)
1970-01-09
IL31761A0
(en)
1969-05-28
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