GB1246051A – Improvements in or relating to isoquinoline derivatives
– Google Patents
GB1246051A – Improvements in or relating to isoquinoline derivatives
– Google Patents
Improvements in or relating to isoquinoline derivatives
Info
Publication number
GB1246051A
GB1246051A
GB344/69A
GB34469A
GB1246051A
GB 1246051 A
GB1246051 A
GB 1246051A
GB 344/69 A
GB344/69 A
GB 344/69A
GB 34469 A
GB34469 A
GB 34469A
GB 1246051 A
GB1246051 A
GB 1246051A
Authority
GB
United Kingdom
Prior art keywords
alkyl
isoquinoline derivatives
derivatives
formulμ
amino
Prior art date
1968-03-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB344/69A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Marion Laboratories Inc
Original Assignee
Marion Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1968-03-26
Filing date
1969-01-02
Publication date
1971-09-15
1969-01-02
Application filed by Marion Laboratories Inc
filed
Critical
Marion Laboratories Inc
1971-09-15
Publication of GB1246051A
publication
Critical
patent/GB1246051A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
Abstract
1,246,051. Isoquinoline derivatives. MARION LABORATORIES Inc. 2 Jan., 1969 [26 March, 1968], No. 344/69. Heading C2C. The invention comprises the preparation of isoquinoline derivatives of the formulµ wherein R is alkyl, or phenyl optionally substituted by 1 to 3 OH, alkyl or alkoxy groups or halogen atoms and R 1 is alkyl by reacting the appropriate amines with acid halides of the formula RCOX, wherein X is halogen and the novel quinoline derivatives of the formulµ wherein R is a substituted phenyl group containing 1 to 3 OH, alkyl or alkoxy groups or halogen atoms, R 1 is alkyl, R 2 is alkyl or phenyl and R 3 represents the groups represented by R and R 2 and acid addition salts thereof. Cis – 5,9,10 – H – 5 – amino – 2 – methyl – decahydroiso quinoline and trans-9,10-t-5-H- 5 – amino – 2 – methyldecahydroisoquinoline are obtained by hydrolysis of the corresponding 5-acetamido compounds. Pharmaceutical compositions suitable for oral or parenteral administration, contain the above novel isoquinoline derivatives and suitable pharmaceutical carriers. The compound are blood pressure lowering agents.
GB344/69A
1968-03-26
1969-01-02
Improvements in or relating to isoquinoline derivatives
Expired
GB1246051A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
US71594668A
1968-03-26
1968-03-26
Publications (1)
Publication Number
Publication Date
GB1246051A
true
GB1246051A
(en)
1971-09-15
Family
ID=24876107
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB344/69A
Expired
GB1246051A
(en)
1968-03-26
1969-01-02
Improvements in or relating to isoquinoline derivatives
Country Status (8)
Country
Link
US
(1)
US3674791A
(en)
BE
(1)
BE730509A
(en)
CA
(1)
CA956961A
(en)
CH
(1)
CH510026A
(en)
DE
(1)
DE1900948A1
(en)
FR
(1)
FR2004748A1
(en)
GB
(1)
GB1246051A
(en)
SE
(2)
SE382212B
(en)
Families Citing this family (10)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US4022900A
(en)
*
1970-09-09
1977-05-10
Marion Laboratories, Inc.
Compositions containing 1,2,3,4-tetrahydroisoquinolines used as hypotensive agents
JPS4824396B1
(en)
*
1970-09-09
1973-07-20
PH19604A
(en)
*
1982-06-04
1986-05-27
Egyt Gyogyszervegyeszeti Gyar
Isoquinoline derivatives and pharmaceutical compositions containing the same
AU572585B2
(en)
*
1983-09-29
1988-05-12
Akzo N.V.
Quinazoline and isoquinoline derivatives
CA1334969C
(en)
*
1988-08-19
1995-03-28
Mark James Suto
Substituted dihydroisoquinoline and phthalazine derivatives as potentiators of the lethal effects of radiation and certain chemotherapeutic agents, selected compounds, analogs andprocess
US5177075A
(en)
*
1988-08-19
1993-01-05
Warner-Lambert Company
Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process
JP2001521026A
(en)
*
1997-10-24
2001-11-06
スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー
Substituted isoquinoline derivatives and use as anticonvulsants
GB9807903D0
(en)
*
1998-04-14
1998-06-10
Smithkline Beecham Plc
Novel compounds
GB9817424D0
(en)
*
1998-08-11
1998-10-07
Smithkline Beecham Plc
Novel compounds
JP2007523152A
(en)
*
2004-02-18
2007-08-16
ファイザー・プロダクツ・インク
Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline
1968
1968-03-26
US
US715946A
patent/US3674791A/en
not_active
Expired – Lifetime
1968-12-30
CA
CA038,998A
patent/CA956961A/en
not_active
Expired
1969
1969-01-02
GB
GB344/69A
patent/GB1246051A/en
not_active
Expired
1969-01-09
DE
DE19691900948
patent/DE1900948A1/en
not_active
Withdrawn
1969-03-25
SE
SE6904151A
patent/SE382212B/en
unknown
1969-03-25
FR
FR6908724A
patent/FR2004748A1/fr
not_active
Withdrawn
1969-03-26
CH
CH458569A
patent/CH510026A/en
not_active
IP Right Cessation
1969-03-26
BE
BE730509D
patent/BE730509A/xx
unknown
1974
1974-11-01
SE
SE7413787A
patent/SE7413787L/xx
unknown
Also Published As
Publication number
Publication date
SE382212B
(en)
1976-01-19
DE1900948A1
(en)
1970-07-02
BE730509A
(en)
1969-09-01
CA956961A
(en)
1974-10-29
US3674791A
(en)
1972-07-04
CH510026A
(en)
1971-07-15
SE7413787L
(en)
1974-11-01
FR2004748A1
(en)
1969-11-28
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