GB1268710A - Creación de Inventos y Patentes con Inteligencia Artificial

GB1268710A – N-arallyl-n’-aralkyl piperazines and pharmaceutical compositions thereof
– Google Patents

GB1268710A – N-arallyl-n’-aralkyl piperazines and pharmaceutical compositions thereof
– Google Patents
N-arallyl-n’-aralkyl piperazines and pharmaceutical compositions thereof

Info

Publication number
GB1268710A

GB1268710A
GB29382/69A
GB2938269A
GB1268710A
GB 1268710 A
GB1268710 A
GB 1268710A
GB 29382/69 A
GB29382/69 A
GB 29382/69A
GB 2938269 A
GB2938269 A
GB 2938269A
GB 1268710 A
GB1268710 A
GB 1268710A
Authority
GB
United Kingdom
Prior art keywords
fluoro
piperazine
compound
piperazines
cinnamyl
Prior art date
1968-07-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB29382/69A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Janssen Pharmaceutica NV

Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1968-07-02
Filing date
1969-06-10
Publication date
1972-03-29

1969-06-10
Application filed by Janssen Pharmaceutica NV
filed
Critical
Janssen Pharmaceutica NV

1972-03-29
Publication of GB1268710A
publication
Critical
patent/GB1268710A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms

C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms

C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals

C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Abstract

1,268,710. Fluoro-substituted N-cinnamyl-N1– benzhydryl piperazine. JANSSEN PHARMACEUTICA N.V. 10 June 1969 [2 July, 1968], No. 29382/69. Heading C2C. Novel fluoro-substituted N-cinnamyl-N1– benzhydryl piperazines of the formula wherein each Ar may be a phenyl or fluorophenyl group, provided that at least one Ar is a fluorophenyl group, may be obtained by reacting a compound with a compound Y-CH 2 -CH=CH-Ar, where Y and Y1 are different and represent a halogen atom or a piperazine residue, in the presence of a base and, if desired, forming a therapeutically active acid addition salt. Preparation of the following intermediates is also described: 1-(p-fluoro-α.-phenylbenzyl)-piperazine from p-fluoro-α-phenylbenzylchloride and piperazine; p-fluorocinnamylchloride from pfluoro-α-vinylbenzyl alcohol and HCl; di-(4- fluorophenyl)-chloromethane from α-(4-fluoro-phenyl)-4-fluorobenzyl alcohol and HCl. Pharmaceutical composition having anti-arrhythmic activity comprises a compound of Formula I above, or a therapeutically active acid addition salt thereof, in admixture with a pharmaceutically acceptable carrier, in forms suitable for oral or parenteral administration.

GB29382/69A
1968-07-02
1969-06-10
N-arallyl-n’-aralkyl piperazines and pharmaceutical compositions thereof

Expired

GB1268710A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

US74199968A

1968-07-02
1968-07-02

Publications (1)

Publication Number
Publication Date

GB1268710A
true

GB1268710A
(en)

1972-03-29

Family
ID=24983099
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB29382/69A
Expired

GB1268710A
(en)

1968-07-02
1969-06-10
N-arallyl-n’-aralkyl piperazines and pharmaceutical compositions thereof

Country Status (20)

Country
Link

AT
(1)

AT289811B
(en)

BE
(1)

BE735452A
(en)

BR
(1)

BR6910304D0
(en)

CH
(1)

CH510677A
(en)

DE
(1)

DE1929330C3
(en)

DK
(1)

DK121175B
(en)

ES
(1)

ES368981A1
(en)

FI
(1)

FI52979C
(en)

FR
(1)

FR2014487A1
(en)

GB
(1)

GB1268710A
(en)

IE
(1)

IE33283B1
(en)

IL
(1)

IL32520A
(en)

LU
(1)

LU58970A1
(en)

NL
(1)

NL162646C
(en)

NO
(1)

NO124776B
(en)

PL
(1)

PL80098B1
(en)

SE
(1)

SE350972B
(en)

SU
(1)

SU403182A3
(en)

YU
(1)

YU36715B
(en)

ZA
(1)

ZA694714B
(en)

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

EP0152799A1
(en)

1984-02-02
1985-08-28
PULITZER ITALIANA S.p.A.
Compounds having peripheral calcium antagonist, anticonvulsive and eumetabolic activity, processes for the preparation thereof and pharmaceutical compositions containing them

1969

1969-06-09
IE
IE783/69A
patent/IE33283B1/en
unknown

1969-06-10
GB
GB29382/69A
patent/GB1268710A/en
not_active
Expired

1969-06-10
DE
DE1929330A
patent/DE1929330C3/en
not_active
Expired

1969-06-13
CH
CH911169A
patent/CH510677A/en
not_active
IP Right Cessation

1969-06-26
SU
SU1341578A
patent/SU403182A3/ru
active

1969-06-26
AT
AT610669A
patent/AT289811B/en
not_active
IP Right Cessation

1969-06-27
FR
FR6921783A
patent/FR2014487A1/fr
active
Pending

1969-06-27
LU
LU58970D
patent/LU58970A1/xx
unknown

1969-06-30
SE
SE09260/69*A
patent/SE350972B/xx
unknown

1969-06-30
BR
BR210304/69A
patent/BR6910304D0/en
unknown

1969-06-30
NL
NL6910007.A
patent/NL162646C/en
not_active
IP Right Cessation

1969-06-30
YU
YU1662/69A
patent/YU36715B/en
unknown

1969-06-30
ES
ES368981A
patent/ES368981A1/en
not_active
Expired

1969-07-01
FI
FI1956/69A
patent/FI52979C/fi
active

1969-07-01
IL
IL32520A
patent/IL32520A/en
unknown

1969-07-01
NO
NO2753/69A
patent/NO124776B/no
unknown

1969-07-01
PL
PL1969134557A
patent/PL80098B1/pl
unknown

1969-07-01
BE
BE735452D
patent/BE735452A/xx
not_active
IP Right Cessation

1969-07-02
ZA
ZA694714A
patent/ZA694714B/en
unknown

1969-07-02
DK
DK357369AA
patent/DK121175B/en
unknown

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

EP0152799A1
(en)

Also Published As

Publication number
Publication date

DE1929330C3
(en)

1979-09-13

FR2014487A1
(en)

1970-04-17

DE1929330A1
(en)

1970-02-12

LU58970A1
(en)

1969-11-12

BR6910304D0
(en)

1973-04-19

CH510677A
(en)

1971-07-31

SU403182A3
(en)

1973-10-19

IE33283B1
(en)

1974-05-15

SE350972B
(en)

1972-11-13

FI52979C
(en)

1978-01-10

ES368981A1
(en)

1971-05-16

FI52979B
(en)

1977-09-30

YU166269A
(en)

1982-02-25

DE1929330B2
(en)

1979-01-18

IE33283L
(en)

1970-01-02

IL32520A0
(en)

1969-09-25

NL162646C
(en)

1980-06-16

NL6910007A
(en)

1970-01-06

YU36715B
(en)

1984-08-31

BE735452A
(en)

1970-01-02

PL80098B1
(en)

1975-08-30

AT289811B
(en)

1971-05-10

ZA694714B
(en)

1971-02-24

DK121175B
(en)

1971-09-20

NO124776B
(en)

1972-06-05

IL32520A
(en)

1972-09-28

Información de contacto