GB1295206A – – Google Patents
GB1295206A – – Google Patents
Info
Publication number
GB1295206A
GB1295206A
GB1295206DA
GB1295206A
GB 1295206 A
GB1295206 A
GB 1295206A
GB 1295206D A
GB1295206D A
GB 1295206DA
GB 1295206 A
GB1295206 A
GB 1295206A
Authority
GB
United Kingdom
Prior art keywords
hydroxyl
derivative
alkylmercapto
july
amino
Prior art date
1970-07-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1970-07-31
Filing date
1971-07-28
Publication date
1972-11-08
1971-07-28
Application filed
filed
Critical
1972-11-08
Publication of GB1295206A
publication
Critical
patent/GB1295206A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 – C07D463/00
C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 – C07D463/00 in which the condensed system contains two hetero rings
C07D471/04—Ortho-condensed systems
Abstract
1295206 Pyrido-pyrimidine derivatives BOEHRINGER MANNHEIM GmbH 28 July 1971 [31 July 1970] 35442/71 Heading C2C Novel compounds of the general Formula I wherein R 1 and R 2 which may be the same or different, are C 1-5 alkyl, alkenyl, cycloalkyl, aralkyl, pyrylalkyl, thenylalkyl or tetrahydrofurylalkyl radicals optionally substituted by hydroxyl, alkoxy or alkylmercapto and wherein one of R 1 and R 2 may be hydrogen; and physiologically compatible acids thereof may be prepared by (a) reaction to compound II wherein X is a reactive group with an amine R 1 R 2 NH ; (b) condensing propargyl aldehyde or a derivative thereof with a compound IV wherein Z is hydroxyl, mercapto or amino, alkoxyl, phenoxy or alkylmercapto and if necessary converting Z simultaneously or subsequently into a hydroxyl group; (c) forming a secondary or tertiary amine from 2-amino-4- hydroxypyrido[2,3-d]pyrimidine; (d) reaction of VI or a cyanide derivative thereof with 2-aminopyridine – 3 – carboxylic acid or a reactive derivative thereof. Pharmaceutical compositions of the compounds I show diuretic and natriuretic activity when administered orally or parenterally with the usual excipients.
GB1295206D
1970-07-31
1971-07-28
Expired
GB1295206A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
DE19702038035
DE2038035A1
(en)
1970-07-31
1970-07-31
2-Amino-pyrido square brackets on 2,3-square brackets to pyrimidin-4 (3H) one derivatives
Publications (1)
Publication Number
Publication Date
GB1295206A
true
GB1295206A
(en)
1972-11-08
Family
ID=5778470
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB1295206D
Expired
GB1295206A
(en)
1970-07-31
1971-07-28
Country Status (11)
Country
Link
US
(1)
US3794637A
(en)
AT
(2)
AT311357B
(en)
AU
(1)
AU450829B2
(en)
CH
(1)
CH563391A5
(en)
DE
(1)
DE2038035A1
(en)
ES
(1)
ES393481A1
(en)
FR
(1)
FR2100976B1
(en)
GB
(1)
GB1295206A
(en)
NL
(1)
NL7110607A
(en)
SE
(1)
SE366992B
(en)
ZA
(1)
ZA715112B
(en)
Families Citing this family (7)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US3931178A
(en)
*
1972-01-28
1976-01-06
Sandoz Inc.
1-Substituted-2-imino-pyrido[2,3-d]pyrimidin-4(1H)-ones
US3931183A
(en)
*
1974-07-24
1976-01-06
Sandoz Inc.
1-Substituted-2-disubstitutedamino-pyrido[2,3-D]pyrimidin-4(1H)-ones
DE2861598D1
(en)
*
1977-07-20
1982-03-11
Wellcome Found
1h-pyrimido-(4,5-c)-1,2-diazepines, methods for their preparation and compositions containing them; their use as intermediates for heterocyclic transformations.
DE3276808D1
(en)
*
1981-09-25
1987-08-27
Southern Res Inst
PYRIDO (2,3-D) PYRIMIDINES
ES2056742B1
(en)
*
1993-02-24
1995-05-01
Antibioticos Farma S A
NEW DERIVATIVES OF PIRIDO (2,3-D) PIRIMIDINA, ITS PREPARATION PROCEDURE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
BR9609613A
(en)
1995-07-05
1999-05-25
Du Pont
Compound fungicidal composition and method of controlling plant diseases
ES2344086T3
(en)
*
2006-05-23
2010-08-17
F. Hoffmann-La Roche Ag
DERIVATIVES OF PIRIDOPIRIMIDINONA.
1970
1970-07-31
DE
DE19702038035
patent/DE2038035A1/en
active
Pending
1971
1971-07-21
ES
ES393481A
patent/ES393481A1/en
not_active
Expired
1971-07-22
US
US00165391A
patent/US3794637A/en
not_active
Expired – Lifetime
1971-07-26
SE
SE09566/71A
patent/SE366992B/xx
unknown
1971-07-28
GB
GB1295206D
patent/GB1295206A/en
not_active
Expired
1971-07-28
CH
CH1111771A
patent/CH563391A5/xx
not_active
IP Right Cessation
1971-07-28
AU
AU31752/71A
patent/AU450829B2/en
not_active
Expired
1971-07-30
AT
AT669571A
patent/AT311357B/en
not_active
IP Right Cessation
1971-07-30
NL
NL7110607A
patent/NL7110607A/xx
unknown
1971-07-30
AT
AT1059472A
patent/AT311369B/en
not_active
IP Right Cessation
1971-07-30
ZA
ZA715112A
patent/ZA715112B/en
unknown
1971-07-30
FR
FR7128001A
patent/FR2100976B1/fr
not_active
Expired
Also Published As
Publication number
Publication date
AT311369B
(en)
1973-11-12
FR2100976A1
(en)
1972-03-24
NL7110607A
(en)
1972-02-02
US3794637A
(en)
1974-02-26
AT311357B
(en)
1973-11-12
CH563391A5
(en)
1975-06-30
AU450829B2
(en)
1974-07-18
AU3175271A
(en)
1973-02-01
FR2100976B1
(en)
1974-09-06
ES393481A1
(en)
1974-09-16
ZA715112B
(en)
1972-05-31
DE2038035A1
(en)
1972-02-03
SE366992B
(en)
1974-05-13
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Legal Events
Date
Code
Title
Description
1973-03-28
PS
Patent sealed [section 19, patents act 1949]
1976-02-25
PLNP
Patent lapsed through nonpayment of renewal fees
