GB1331203A – Substituted methoxyamine derivatives
– Google Patents
GB1331203A – Substituted methoxyamine derivatives
– Google Patents
Substituted methoxyamine derivatives
Info
Publication number
GB1331203A
GB1331203A
GB553172A
GB553172A
GB1331203A
GB 1331203 A
GB1331203 A
GB 1331203A
GB 553172 A
GB553172 A
GB 553172A
GB 553172 A
GB553172 A
GB 553172A
GB 1331203 A
GB1331203 A
GB 1331203A
Authority
GB
United Kingdom
Prior art keywords
base
salt
general formula
phthalimide
prepared
Prior art date
1971-02-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB553172A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ivax Drug Research Institute Ltd
Original Assignee
Ivax Drug Research Institute Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1971-02-15
Filing date
1972-02-07
Publication date
1973-09-26
1972-02-07
Application filed by Ivax Drug Research Institute Ltd
filed
Critical
Ivax Drug Research Institute Ltd
1973-09-26
Publication of GB1331203A
publication
Critical
patent/GB1331203A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
C07D209/44—Iso-indoles; Hydrogenated iso-indoles
C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
C07D213/30—Oxygen atoms
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
C07D235/12—Radicals substituted by oxygen atoms
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
C07D277/62—Benzothiazoles
C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
Abstract
1331203 Methoxyamine derivatives GYOGYSZERKUTATO INTEZET 7 Feb 1972 [15 Feb 1971] 5531/72 Heading C2C A process for the preparation of substituted methoxy amines of general formula in which R 1 represents an aliphatic, aromatic or heterocyclic radical and R 2 is a hydrogen atom or a saturated or unsaturated, straight-chained or branched, C 1-4 alkyl group and salts thereof, comprises reacting a compound of general formula R 1 -CH(R 2 )ON=A in which A is a substituted or unsubstituted phthaloyl group with a base of general formula R 3 -NH 2 or a salt thereof in which R 3 is hydrogen or an aliphatic, aromatic, araliphatic, alicyclic or heterocyclic radical and, if desired, transforming a base into a salt using an acid or forming a free base from a salt using a strong base. The reaction is carried out using equimolar amounts of phthalimide and primary amine and by reflux in C 1-3 aliphatic alcohol or in the absence of a solvent with the phthalimide and amine being fused at the boiling point of the amine. Novel compounds prepared by the process are crotyloxyamine, 4 – n – octyloxy – 3,5 – dimethoxybenzyloxyamine, and 1-(pyrid-3-yl)ethyloxyamine. The phthalimides from which the above compounds are prepared, are novel and are prepared by reacting N-hydroxy phthalimide with the appropriate halide in the presence of a base.
GB553172A
1971-02-15
1972-02-07
Substituted methoxyamine derivatives
Expired
GB1331203A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
HUGO001155
HU162578B
(en)
1971-02-15
1971-02-15
Publications (1)
Publication Number
Publication Date
GB1331203A
true
GB1331203A
(en)
1973-09-26
Family
ID=10996690
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB553172A
Expired
GB1331203A
(en)
1971-02-15
1972-02-07
Substituted methoxyamine derivatives
Country Status (10)
Country
Link
AT
(1)
AT316511B
(en)
CA
(1)
CA989394A
(en)
CH
(1)
CH566961A5
(en)
DE
(1)
DE2206890A1
(en)
DK
(1)
DK142027B
(en)
FR
(1)
FR2131350A5
(en)
GB
(1)
GB1331203A
(en)
HU
(1)
HU162578B
(en)
NL
(1)
NL7201784A
(en)
SE
(1)
SE387936B
(en)
Cited By (6)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
DE2651083A1
(en)
*
1976-11-09
1978-05-18
Hoechst Ag
NEW O-ALKYLATED HYDROXYLAMINE, METHOD FOR THEIR PRODUCTION AND THEIR USE
US5120849A
(en)
*
1986-05-07
1992-06-09
Basf Aktiengesellschaft
Preparation of o-substituted hydroxylamines
GB2296715A
(en)
*
1994-10-28
1996-07-10
Commw Scient Ind Res Org
Allyloxyimides
AU705642B2
(en)
*
1994-10-28
1999-05-27
Commonwealth Scientific And Industrial Research Organisation
Bisallyloxyimides
US7312200B2
(en)
2003-01-17
2007-12-25
Bayer Cropscience Ag
9-ketospinosyn derivatives
US20130289083A1
(en)
*
2007-11-30
2013-10-31
Newlink Genetics Corporation
IDO Inhibitors
1971
1971-02-15
HU
HUGO001155
patent/HU162578B/hu
unknown
1972
1972-02-07
GB
GB553172A
patent/GB1331203A/en
not_active
Expired
1972-02-10
CA
CA134,406A
patent/CA989394A/en
not_active
Expired
1972-02-11
NL
NL7201784A
patent/NL7201784A/xx
not_active
Application Discontinuation
1972-02-14
DK
DK66872A
patent/DK142027B/en
unknown
1972-02-14
DE
DE19722206890
patent/DE2206890A1/en
active
Pending
1972-02-14
SE
SE173272A
patent/SE387936B/en
unknown
1972-02-15
AT
AT120172A
patent/AT316511B/en
not_active
IP Right Cessation
1972-02-15
FR
FR7204947A
patent/FR2131350A5/fr
not_active
Expired
1972-02-15
CH
CH214772A
patent/CH566961A5/xx
not_active
IP Right Cessation
Cited By (9)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
DE2651083A1
(en)
*
1976-11-09
1978-05-18
Hoechst Ag
NEW O-ALKYLATED HYDROXYLAMINE, METHOD FOR THEIR PRODUCTION AND THEIR USE
US5120849A
(en)
*
1986-05-07
1992-06-09
Basf Aktiengesellschaft
Preparation of o-substituted hydroxylamines
GB2296715A
(en)
*
1994-10-28
1996-07-10
Commw Scient Ind Res Org
Allyloxyimides
US5760165A
(en)
*
1994-10-28
1998-06-02
Commonwealth Scientific And Industrial Research Organization (Csiro)
Bisallyloxyimides
GB2296715B
(en)
*
1994-10-28
1998-09-16
Commw Scient Ind Res Org
Bisallyloxyimides
AU705642B2
(en)
*
1994-10-28
1999-05-27
Commonwealth Scientific And Industrial Research Organisation
Bisallyloxyimides
US7312200B2
(en)
2003-01-17
2007-12-25
Bayer Cropscience Ag
9-ketospinosyn derivatives
US20130289083A1
(en)
*
2007-11-30
2013-10-31
Newlink Genetics Corporation
IDO Inhibitors
US10047066B2
(en)
2007-11-30
2018-08-14
Newlink Genetics Corporation
IDO inhibitors
Also Published As
Publication number
Publication date
DK142027C
(en)
1981-02-16
CA989394A
(en)
1976-05-18
HU162578B
(en)
1973-03-28
DK142027B
(en)
1980-08-11
AT316511B
(en)
1974-07-10
DE2206890A1
(en)
1972-08-31
FR2131350A5
(en)
1972-11-10
NL7201784A
(en)
1972-08-17
CH566961A5
(en)
1975-09-30
SE387936B
(en)
1976-09-20
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Legal Events
Date
Code
Title
Description
1974-02-06
PS
Patent sealed
1974-06-05
435
Patent endorsed ‘licences of right’ on the date specified (sect. 35/1949)
1981-09-23
PCNP
Patent ceased through non-payment of renewal fee
