GB1331933A – Antiviral ribonucleic acids
– Google Patents
GB1331933A – Antiviral ribonucleic acids
– Google Patents
Antiviral ribonucleic acids
Info
Publication number
GB1331933A
GB1331933A
GB1331933DA
GB1331933A
GB 1331933 A
GB1331933 A
GB 1331933A
GB 1331933D A
GB1331933D A
GB 1331933DA
GB 1331933 A
GB1331933 A
GB 1331933A
Authority
GB
United Kingdom
Prior art keywords
particles
virus
antiviral
ribonucleic acids
ribonucleic
Prior art date
1969-11-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1969-11-17
Filing date
1969-11-17
Publication date
1973-09-26
1969-11-17
Application filed by Glaxo Laboratories Ltd
filed
Critical
Glaxo Laboratories Ltd
1973-09-26
Publication of GB1331933A
publication
Critical
patent/GB1331933A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
C12P19/00—Preparation of compounds containing saccharide radicals
C12P19/26—Preparation of nitrogen-containing carbohydrates
C12P19/28—N-glycosides
C12P19/30—Nucleotides
C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
C—CHEMISTRY; METALLURGY
C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
C—CHEMISTRY; METALLURGY
C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
C12N2770/00011—Details
C12N2770/24011—Flaviviridae
C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
C12N2770/24123—Virus like particles [VLP]
Abstract
1331933 Antiviral ribonucleic acids GLAXO LABORATORIES Ltd 13 Nov 1970 [17 Nov 1969] 56169/69 Heading C3H [Also in Division A5] A process for the production of one or both of the antiviral ribonucleic acids I and II from P. chrysogenum having the characteristics: ribonucleic acid IS 20,w (as herein defined) = 11À7 to 12À3 Base analysis: Guanine 25À0% Œ 1À0 Adenine 25À0% Œ 1À0. Cytosine 25À0% Œ 1À0. Uracil 25À0% Œ 1À0. Ribonucleic acid IIS 20,w (as herein defined) = 6-7 to 7À3 Base analysis: Guanine 18À0% Œ 1À0. Adenine 32À0% Œ 1À0. Cytosine 18À0% Œ 1À0. Uracil 32À0% Œ 1À0. Said process comprising the steps of (a) culturing a strain of P. chrysogenum, preferably ATCC 10,002, 10,003, 11,707, 13,799 or a mutant thereof in or on a nutrient medium therefor whereby virus-like particles as herein defined proliferate therein; (b) rupture of the cells of the micro-organism without removing the coating of the virus-like particles, and then removal of cell debris from the virus-like particles; (c) partial or complete separation of the viruslike particles from free nucleic acids and other dissolved materials; (d) decoating the virus-like particles; and (e) fractionation whereby the desired antiviral double-stranded ribonucleic acids I and II are isolated and unwanted material is rejected. Pharmaceutical compositions may be prepared from the products.
GB1331933D
1969-11-17
1969-11-17
Antiviral ribonucleic acids
Expired
GB1331933A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
GB5616969
1969-11-17
Publications (1)
Publication Number
Publication Date
GB1331933A
true
GB1331933A
(en)
1973-09-26
Family
ID=10475915
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB1331933D
Expired
GB1331933A
(en)
1969-11-17
1969-11-17
Antiviral ribonucleic acids
Country Status (5)
Country
Link
BE
(1)
BE758977A
(en)
DE
(1)
DE2056294A1
(en)
FR
(1)
FR2073366B1
(en)
GB
(1)
GB1331933A
(en)
NL
(1)
NL7016747A
(en)
Cited By (3)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
EP0063657A1
(en)
*
1981-04-29
1982-11-03
Merck & Co. Inc.
Topical application of interferon inducers
US4908318A
(en)
*
1987-09-04
1990-03-13
Integrated Genetics, Inc.
Nucleic acid extraction methods
US5057426A
(en)
*
1986-11-22
1991-10-15
Diagen Institut Fur Molekular-Biologische, Diagnostik Gmbh
Method for separating long-chain nucleic acids
Families Citing this family (3)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
WO1981001102A1
(en)
*
1979-10-19
1981-04-30
A Romano
Medicine for the treatment of viral infections of the eye and other organs
FR2550707B1
(en)
*
1983-08-17
1986-02-28
Lipha
IMMUNOMODULATOR OF BIOLOGICAL MEDICINE AND PROCESS FOR PREPARING THE SAME
DE3833925A1
(en)
*
1988-03-11
1989-09-21
Inst Angewandte Biotechnologie
PROCESS AND MANUFACTURE OF VIRUS AND VIRAL ANTIGEN AND DEVICE THEREFOR
0
BE
BE758977D
patent/BE758977A/en
unknown
1969
1969-11-17
GB
GB1331933D
patent/GB1331933A/en
not_active
Expired
1970
1970-11-16
FR
FR7041032A
patent/FR2073366B1/fr
not_active
Expired
1970-11-16
DE
DE19702056294
patent/DE2056294A1/en
active
Pending
1970-11-16
NL
NL7016747A
patent/NL7016747A/xx
unknown
Cited By (3)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
EP0063657A1
(en)
*
1981-04-29
1982-11-03
Merck & Co. Inc.
Topical application of interferon inducers
US5057426A
(en)
*
1986-11-22
1991-10-15
Diagen Institut Fur Molekular-Biologische, Diagnostik Gmbh
Method for separating long-chain nucleic acids
US4908318A
(en)
*
1987-09-04
1990-03-13
Integrated Genetics, Inc.
Nucleic acid extraction methods
Also Published As
Publication number
Publication date
NL7016747A
(en)
1971-05-19
FR2073366A1
(en)
1971-10-01
DE2056294A1
(en)
1971-07-15
BE758977A
(en)
1971-05-17
FR2073366B1
(en)
1975-08-01
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Legal Events
Date
Code
Title
Description
1974-02-06
PS
Patent sealed
1977-06-10
PLNP
Patent lapsed through nonpayment of renewal fees
