GB1347036A – L-biphenylealkaoic acids
– Google Patents
GB1347036A – L-biphenylealkaoic acids
– Google Patents
L-biphenylealkaoic acids
Info
Publication number
GB1347036A
GB1347036A
GB4150071A
GB4150071A
GB1347036A
GB 1347036 A
GB1347036 A
GB 1347036A
GB 4150071 A
GB4150071 A
GB 4150071A
GB 4150071 A
GB4150071 A
GB 4150071A
GB 1347036 A
GB1347036 A
GB 1347036A
Authority
GB
United Kingdom
Prior art keywords
formula
alkoxy
radical
alkylamino
prepared
Prior art date
1970-09-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4150071A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1970-09-15
Filing date
1971-09-06
Publication date
1974-02-13
1971-09-06
Application filed by Merck and Co Inc
filed
Critical
Merck and Co Inc
1974-02-13
Publication of GB1347036A
publication
Critical
patent/GB1347036A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
C07C59/40—Unsaturated compounds
C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
C07C57/50—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid containing condensed ring systems
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
C07C57/62—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings and other rings
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
C07C59/40—Unsaturated compounds
C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
C07C59/54—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings and other rings
Abstract
1347036 Biphenylene derivatives MERCK & CO Inc 6 Sept 1971 [15 Sept 1970] 41500/71 Heading C2C Novel compounds of Formula I where R is a hydrogen atom or an alkyl, alkoxy, alkenyl, alkylamino or haloalkyl radical; each of R 1 and R 2 , which may be the same as or different from the others, is a hydrogen or halogen atom or a nitro, amino, alkylamino, dialkylamino, alkenyloxy, alkenyl, acylamino, cyano, carboxy, alkoxy carbonyl, carbamoyl, methylenedioxy, trihaloalkyl, alkoxy, alkyl, mercapto, alkylthio, alkylsulfinyl, alkylsulfonyl, sulfonamido, sulfinamido, aryl, aralkyl, aryloxy, aralkoxy, hydroxy, hydroxyalkyl, ahloalkyl, mercaptoalkyl, alkylmercaptoalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkoxyalkyl, acyl or acyloxy radical; and Y is a hydroxy, amino, alkylamino, dialkylamino, cycloalkylamino, N-heterocyclo, alkoxy or aralkoxy radical, or a radical of formula-OMe where Me is a non-toxic cation are prepared either by hydrolysis of a novel nitrile of Formula II where R, R 1 and R 2 are as above except that R 1 and R 2 are not cyano, acylamino, carboxy or haloalkyl, prepared by reacting NaCN with the halide Br for CN in II above; or by reacting a compound of Formula III with a secondary amine and sulphur and hydrolysing the reaction product in situ and in both cases optionally converting a group R 2 or R 1 or Y into another by standard methods or forming a salt. Intermediates of Formula IV where R 1 and R 2 are each H, alkyl aryl, aralkyl, halogen or CF 3 are prepared by halogenation of the corresponding alcohols which are obtained by reduction of the acetylbiphenylenes. Pharmaceutical compositions in conventional forms for topical, oral, rectal or parenteral administration and having anti-inflammatory, analgesic and antipyretic activity comprise an above novel compound of Formula I and a carrier or diluent.
GB4150071A
1970-09-15
1971-09-06
L-biphenylealkaoic acids
Expired
GB1347036A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
US7253170A
1970-09-15
1970-09-15
Publications (1)
Publication Number
Publication Date
GB1347036A
true
GB1347036A
(en)
1974-02-13
Family
ID=22108199
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB4150071A
Expired
GB1347036A
(en)
1970-09-15
1971-09-06
L-biphenylealkaoic acids
Country Status (6)
Country
Link
CA
(1)
CA940536A
(en)
CH
(1)
CH572014A5
(en)
DE
(1)
DE2145932A1
(en)
FR
(1)
FR2106541B1
(en)
GB
(1)
GB1347036A
(en)
NL
(1)
NL7111913A
(en)
Family Cites Families (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
NL7008626A
(en)
*
1969-06-25
1970-12-29
1971
1971-08-30
NL
NL7111913A
patent/NL7111913A/xx
not_active
Application Discontinuation
1971-09-02
CA
CA 122026
patent/CA940536A/en
not_active
Expired
1971-09-06
GB
GB4150071A
patent/GB1347036A/en
not_active
Expired
1971-09-13
CH
CH1339371A
patent/CH572014A5/xx
not_active
IP Right Cessation
1971-09-14
DE
DE19712145932
patent/DE2145932A1/en
active
Pending
1971-09-15
FR
FR7133236A
patent/FR2106541B1/fr
not_active
Expired
Also Published As
Publication number
Publication date
FR2106541A1
(en)
1972-05-05
CA940536A
(en)
1974-01-22
FR2106541B1
(en)
1974-09-06
CH572014A5
(en)
1976-01-30
DE2145932A1
(en)
1972-03-16
NL7111913A
(en)
1972-03-17
AU3302571A
(en)
1973-03-08
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Legal Events
Date
Code
Title
Description
1974-07-03
PS
Patent sealed
1980-04-16
PCNP
Patent ceased through non-payment of renewal fee
