GB1348186A

GB1348186A – 17alpha-propadienyl steroids
– Google Patents

GB1348186A – 17alpha-propadienyl steroids
– Google Patents
17alpha-propadienyl steroids

Info

Publication number
GB1348186A

GB1348186A
GB993171*[A
GB993171A
GB1348186A
GB 1348186 A
GB1348186 A
GB 1348186A

GB 993171 A
GB993171 A
GB 993171A
GB 1348186 A
GB1348186 A
GB 1348186A
Authority
GB
United Kingdom
Prior art keywords
prepared
steroids
compounds
ketals
alkyl
Prior art date
1970-04-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB993171*[A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sandoz AG

Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1970-04-24
Filing date
1971-04-19
Publication date
1974-03-13

1971-04-19
Application filed by Sandoz AG
filed
Critical
Sandoz AG

1974-03-13
Publication of GB1348186A
publication
Critical
patent/GB1348186A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K31/00—Medicinal preparations containing organic active ingredients

A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids

A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol

A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K31/00—Medicinal preparations containing organic active ingredients

A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07J—STEROIDS

C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane

Abstract

1348186 17α-Propadienyl-steroids SANDOZ Ltd 19 April 1971 [24 April 1970] 9931/71 Heading C2U [Also in Division A5] Novel steroids of the formula (wherein R is CH 3 , C 2 H 5 or n-C 3 H 7 ) are prepared (1) by dehydrogenation of the corresponding #5(10),9(11)-steroids using a suitable quinone; or (2) by acid hydrolysis of the corresponding 3-ketals. Starting materials of the formula are prepared by acid hydrolysis of the corresponding 3-ketals. These ketals and the starting materials of the formula (where K is a ketal function) are prepared by reacting the corresponding 17-ones with compounds P-C#C-CH 2 NR 1 R 2 (wherein P is an active metal or metal halide radical and R 1 and R 2 are each C 1-3 alkyl or NR 1 R 2 is pyrrolidino, piperidino or homopiperidino) to form the corresponding 17α – (C#C-CH 2 -NR 1 R 2 )- 17#-ols (which may also be prepared from the corresponding 17α-ethynyl compounds and compounds HO-CH 2 -NR 1 R 2 , the ethynyl compounds being in turn prepared from the 17-ones), quaternizing these with a reagent R 3 X (wherein R 3 is C 1-3 alkyl and X is the residue of a mineral acid other than HF or of an alkyl- or aromaticsulphonic acid) and reducing the quaternary derivatives with a hydride ion source. Reference has been directed by the Comptroller to Specification 1,310,611.

GB993171*[A
1970-04-24
1971-04-19
17alpha-propadienyl steroids

Expired

GB1348186A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

US3178270A

1970-04-24
1970-04-24

Publications (1)

Publication Number
Publication Date

GB1348186A
true

GB1348186A
(en)

1974-03-13

Family
ID=21861362
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB993171*[A
Expired

GB1348186A
(en)

1970-04-24
1971-04-19
17alpha-propadienyl steroids

Country Status (11)

Country
Link

AT
(1)

ATA353071A
(en)

AU
(1)

AU2810571A
(en)

BE
(1)

BE766148A
(en)

CA
(1)

CA945141A
(en)

CS
(1)

CS155974B2
(en)

DE
(1)

DE2119328A1
(en)

ES
(1)

ES390456A1
(en)

FR
(1)

FR2092083B1
(en)

GB
(1)

GB1348186A
(en)

NL
(1)

NL7105446A
(en)

ZA
(2)

ZA712601B
(en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

NL127071C
(en)

*

1964-12-31

IL34228A
(en)

*

1969-04-18
1975-04-25
Syntex Corp
The preparation of 17alpha-propadienyl steroids and novel 17alpha-(3-substituted propynyl)steroidal intermediates

1971

1971-04-19
GB
GB993171*[A
patent/GB1348186A/en
not_active
Expired

1971-04-21
DE
DE19712119328
patent/DE2119328A1/en
active
Pending

1971-04-22
ZA
ZA712601A
patent/ZA712601B/en
unknown

1971-04-22
FR
FR7114358A
patent/FR2092083B1/fr
not_active
Expired

1971-04-22
BE
BE766148A
patent/BE766148A/en
unknown

1971-04-22
ES
ES390456A
patent/ES390456A1/en
not_active
Expired

1971-04-22
CA
CA111,058A
patent/CA945141A/en
not_active
Expired

1971-04-22
NL
NL7105446A
patent/NL7105446A/xx
unknown

1971-04-23
ZA
ZA712643A
patent/ZA712643B/en
unknown

1971-04-23
AU
AU28105/71A
patent/AU2810571A/en
not_active
Expired

1971-04-23
CS
CS299571A
patent/CS155974B2/cs
unknown

1971-04-23
AT
AT713530A
patent/ATA353071A/en
not_active
IP Right Cessation

Also Published As

Publication number
Publication date

CS155974B2
(en)

1974-06-24

DE2119328A1
(en)

1971-11-11

NL7105446A
(en)

1971-10-26

AU2810571A
(en)

1972-10-26

ATA353071A
(en)

1975-02-15

ZA712643B
(en)

1972-11-29

BE766148A
(en)

1971-10-22

ES390456A1
(en)

1974-07-01

ZA712601B
(en)

1972-11-29

CA945141A
(en)

1974-04-09

FR2092083A1
(en)

1972-01-21

FR2092083B1
(en)

1974-08-23

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(en)

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(en)

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(en)

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(en)

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Method of adding hydrogen bromide to vinylaryl compounds

Legal Events

Date
Code
Title
Description

1974-07-24
PS
Patent sealed

1975-11-26
PLNP
Patent lapsed through nonpayment of renewal fees

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