GB1395433A

GB1395433A – Preparation of malonic acid derivatives
– Google Patents

GB1395433A – Preparation of malonic acid derivatives
– Google Patents
Preparation of malonic acid derivatives

Info

Publication number
GB1395433A

GB1395433A
GB2586473A
GB2586473A
GB1395433A
GB 1395433 A
GB1395433 A
GB 1395433A
GB 2586473 A
GB2586473 A
GB 2586473A
GB 2586473 A
GB2586473 A
GB 2586473A
GB 1395433 A
GB1395433 A
GB 1395433A
Authority
GB
United Kingdom
Prior art keywords
ester
malonic acid
acid
orthoformic
reaction
Prior art date
1972-06-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB2586473A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Dynamit Nobel AG

Original Assignee
Dynamit Nobel AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1972-06-07
Filing date
1973-05-30
Publication date
1975-05-29

1972-06-07
Priority claimed from DE19722227651
external-priority
patent/DE2227651C3/en

1973-05-30
Application filed by Dynamit Nobel AG
filed
Critical
Dynamit Nobel AG

1975-05-29
Publication of GB1395433A
publication
Critical
patent/GB1395433A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members

C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members

C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom

C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

C07D213/72—Nitrogen atoms

C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Abstract

1395433 Pyridylaminomethylene malonic acid derivatives DYNAMIT NOBEL AG 30 May 1973 [7 June 1972] 25864/73 Heading C2C Pyridylaminomethylene malonic acid derivatives are obtained by reacting in a single stage and in the absence of acetic anhydride and zinc chloride at 60‹ to 160‹ C. an optionally alkylsubstituted aminopyridine with a malonic acid derivative (e.g. a diester or a cyanoacetic acid ester) and a stoichiometric excess of an orthoformic acid ester. The process is exemplified by the reaction wherein R, R1 and R11 are the same or different alkyl groups and R may also be a hydrogen atom. The preferred aminopyridine: malonic acid derivative: orthoformic acid ester molar ratio is from 1 : 1 : 2 to 1 : 1À5 : 5 and the reaction is preferably effected under superatmospheric pressure, the alcohol formed in the reaction generally being removed by distillation. Examples describe the reaction of 2-aminopyridine and 2-amino-6-methyl-pyridine with malonic acid diethyl ester and orthoformic acid triethyl ester, of 2-amino-6-methylpyridine with cyanoacetic acid ethyl ester and orthoformic acid triethyl ester and of 2-amino-6-methylpyridine with malonic acid dimethyl ester and orthoformic acid trimethyl ester. The products are bacteriostatic.

GB2586473A
1972-06-07
1973-05-30
Preparation of malonic acid derivatives

Expired

GB1395433A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

DE19722227651

DE2227651C3
(en)

1972-06-07

Process for the preparation of pyridyl-2-aminomethylene malonic acid derivatives

Publications (1)

Publication Number
Publication Date

GB1395433A
true

GB1395433A
(en)

1975-05-29

Family
ID=5847047
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB2586473A
Expired

GB1395433A
(en)

1972-06-07
1973-05-30
Preparation of malonic acid derivatives

Country Status (8)

Country
Link

JP
(1)

JPS6213348B2
(en)

BE
(1)

BE799919A
(en)

CA
(1)

CA1010877A
(en)

CH
(1)

CH577970A5
(en)

ES
(1)

ES415603A1
(en)

FR
(1)

FR2187783B1
(en)

GB
(1)

GB1395433A
(en)

IT
(1)

IT1045530B
(en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

JPS5218704B2
(en)

*

1972-12-29
1977-05-24

JPH06109243A
(en)

*

1992-09-24
1994-04-19
Samuson:Kk
Boiler combustion control method

1973

1973-05-23
BE
BE131423A
patent/BE799919A/en
not_active
IP Right Cessation

1973-05-30
GB
GB2586473A
patent/GB1395433A/en
not_active
Expired

1973-06-01
CH
CH794973A
patent/CH577970A5/xx
not_active
IP Right Cessation

1973-06-04
IT
IT5042273A
patent/IT1045530B/en
active

1973-06-06
ES
ES415603A
patent/ES415603A1/en
not_active
Expired

1973-06-06
CA
CA173,306A
patent/CA1010877A/en
not_active
Expired

1973-06-06
FR
FR7320643A
patent/FR2187783B1/fr
not_active
Expired

1973-06-07
JP
JP48064350A
patent/JPS6213348B2/ja
not_active
Expired

Also Published As

Publication number
Publication date

CH577970A5
(en)

1976-07-30

BE799919A
(en)

1973-09-17

DE2227651A1
(en)

1973-12-20

FR2187783B1
(en)

1977-02-11

IT1045530B
(en)

1980-05-10

JPS4954381A
(en)

1974-05-27

JPS6213348B2
(en)

1987-03-25

FR2187783A1
(en)

1974-01-18

CA1010877A
(en)

1977-05-24

ES415603A1
(en)

1976-01-16

DE2227651B2
(en)

1977-03-10

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Legal Events

Date
Code
Title
Description

1975-10-08
PS
Patent sealed

1986-02-12
PCNP
Patent ceased through non-payment of renewal fee

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