GB1439089A

GB1439089A – Acylated 2-aminothiazole derivatives and process for the preparation thereof
– Google Patents

GB1439089A – Acylated 2-aminothiazole derivatives and process for the preparation thereof
– Google Patents
Acylated 2-aminothiazole derivatives and process for the preparation thereof

Info

Publication number
GB1439089A

GB1439089A
GB4768574A
GB4768574A
GB1439089A
GB 1439089 A
GB1439089 A
GB 1439089A
GB 4768574 A
GB4768574 A
GB 4768574A
GB 4768574 A
GB4768574 A
GB 4768574A
GB 1439089 A
GB1439089 A
GB 1439089A
Authority
GB
United Kingdom
Prior art keywords
general formula
group
reacting
thiazoles
acid addition
Prior art date
1973-11-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB4768574A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Egyt Gyogyszervegyeszeti Gyar

Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1973-11-09
Filing date
1974-11-04
Publication date
1976-06-09

1974-11-04
Application filed by Egyt Gyogyszervegyeszeti Gyar
filed
Critical
Egyt Gyogyszervegyeszeti Gyar

1976-06-09
Publication of GB1439089A
publication
Critical
patent/GB1439089A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00

C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings

C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings

C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings

C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members

C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

C07D277/38—Nitrogen atoms

C07D277/44—Acylated amino or imino radicals

C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00

C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

1439089 2-Aminoacetamido-thiazoles EGYT GYOGYSZERVEGYESZETI GYAR 4 Nov 1974 [9 Nov 1973] 47685/74 Heading C2C Novel 2-aminoacetamido-thiazoles of the general formula wherein R1 is a phenyl or pyridyl group, R2 is a hydrogen atom or a C 1 -C 4 alkyl group, R3 is a hydrogen atom or a C 1 -C 4 alkyl or benzyl group and each of R4 and R5 is a hydrogen atom or a C 1 -C 8 alkyl, allyl, hydroxyalkyl, C 3 -C 6 cycloalkyl, #-dimethylaminoethyl, #- diethylaminoethyl benzyl, 2-furylmethyl or phenyl(optionally halo-, methyl-, methoxy- or trifluoromethyl-substituted) group or NR4R5 is a 5-8-ring-membered polymethyleneimino, morpholino, piperazino, N-methylpiperazino or N-phenylpiperazino group,and pharmaceutically acceptable acid addition salts thereof are prepared (a) by reacting a 2-haloacetylaminothiazole of the general formula wherein Q is X-CH(R3)-CO- and X is a halogen atom, with R4R5NH, (b) by reacting a 2-amino-4-R1-S-R2-thiazole with wherein Z is a halogen atom or C 1 -C 4 alkoxy or azido group; and (c) by reacting a ketone of the general formula R1COCH(X)-R2 with a thiourea of the general formula and, if desired, converting a resulting base to an appropriate acid addition salt or a resulting salt to the free base. 2 – Haloacetylamino – thiazoles of the second general formula above are prepared by reacting the corresponding 2-aminothiazole with a haloacetyl halide. Pharmaceutical compositions having an inhibiting effect on gastric juice secretion comprise as active ingredient, a 2-aminoacetamidothiazole of the first general formula above or a pharmaceutically acceptable acid addition salt thereof, together with a carrier or diluent.

GB4768574A
1973-11-09
1974-11-04
Acylated 2-aminothiazole derivatives and process for the preparation thereof

Expired

GB1439089A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

HUGO1250A

HU168776B
(en)

1973-11-09
1973-11-09

Publications (1)

Publication Number
Publication Date

GB1439089A
true

GB1439089A
(en)

1976-06-09

Family
ID=10996754
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB4768574A
Expired

GB1439089A
(en)

1973-11-09
1974-11-04
Acylated 2-aminothiazole derivatives and process for the preparation thereof

Country Status (20)

Country
Link

US
(1)

US3963735A
(en)

JP
(1)

JPS50111066A
(en)

AT
(1)

AT347451B
(en)

BE
(1)

BE822028A
(en)

CA
(1)

CA1038379A
(en)

CH
(1)

CH612429A5
(en)

CS
(1)

CS197238B2
(en)

DD
(1)

DD114265A5
(en)

DE
(1)

DE2453147A1
(en)

DK
(1)

DK139723B
(en)

ES
(1)

ES431804A1
(en)

FR
(1)

FR2250526B1
(en)

GB
(1)

GB1439089A
(en)

HU
(1)

HU168776B
(en)

IL
(1)

IL45950A
(en)

IN
(1)

IN139357B
(en)

NL
(1)

NL7414519A
(en)

PL
(1)

PL95852B1
(en)

SE
(1)

SE7414000L
(en)

SU
(1)

SU615858A3
(en)

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

EP0005070A2
(en)

*

1978-04-24
1979-10-31
Pfizer Inc.
N-(2-thiazolyl)amides and their use as anti-inflammatory and immunoregulatory agents

Families Citing this family (5)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US4374843A
(en)

*

1980-10-14
1983-02-22
Pfizer Inc.
2-Guanidino-4-heteroarylthiazoles

EP0149884B1
(en)

*

1983-09-09
1992-12-16
Takeda Chemical Industries, Ltd.
5-pyridyl-1,3-thiazole derivatives, their production and use

FR2618780B1
(en)

*

1987-07-29
1989-12-08
Irceba

THIAZOLE DERIVATIVES BELONGING TO THE FAMILY OF 2-PIPERAZINOACETAMIDO-4-METHYLTHIAZOLES, METHOD OF PREPARATION AND THERAPEUTIC USE

WO2015002926A1
(en)

2013-07-02
2015-01-08
Bristol-Myers Squibb Company
Tricyclic pyrido-carboxamide derivatives as rock inhibitors

WO2015002915A1
(en)

2013-07-02
2015-01-08
Bristol-Myers Squibb Company
Tricyclic pyri do-carboxam i d e derivatives as rock inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US3705153A
(en)

*

1969-05-14
1972-12-05
Sumitomo Chemical Co
Novel thiazolyacetic acids and salts thereof

US3806512A
(en)

*

1970-09-03
1974-04-23
Yoshitomi Pharmaceutical
2-amino-3-pyridylcarbonylthiophene compounds

1973

1973-11-09
HU
HUGO1250A
patent/HU168776B/hu
unknown

1974

1974-10-29
IL
IL45950A
patent/IL45950A/en
unknown

1974-10-29
US
US05/518,732
patent/US3963735A/en
not_active
Expired – Lifetime

1974-11-04
GB
GB4768574A
patent/GB1439089A/en
not_active
Expired

1974-11-05
CH
CH1477074A
patent/CH612429A5/xx
not_active
IP Right Cessation

1974-11-06
AT
AT888174A
patent/AT347451B/en
not_active
IP Right Cessation

1974-11-06
SU
SU742077750A
patent/SU615858A3/en
active

1974-11-07
NL
NL7414519A
patent/NL7414519A/en
not_active
Application Discontinuation

1974-11-07
SE
SE7414000A
patent/SE7414000L/xx
unknown

1974-11-07
CS
CS747598A
patent/CS197238B2/en
unknown

1974-11-08
CA
CA213,315A
patent/CA1038379A/en
not_active
Expired

1974-11-08
DD
DD182249A
patent/DD114265A5/xx
unknown

1974-11-08
BE
BE150365A
patent/BE822028A/en
unknown

1974-11-08
DE
DE19742453147
patent/DE2453147A1/en
not_active
Withdrawn

1974-11-08
FR
FR7437090A
patent/FR2250526B1/fr
not_active
Expired

1974-11-08
DK
DK583974AA
patent/DK139723B/en
unknown

1974-11-08
PL
PL1974175437A
patent/PL95852B1/en
unknown

1974-11-09
ES
ES431804A
patent/ES431804A1/en
not_active
Expired

1974-11-09
JP
JP49129467A
patent/JPS50111066A/ja
active
Pending

1974-12-13
IN
IN2746/CAL/74A
patent/IN139357B/en
unknown

Cited By (2)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

EP0005070A2
(en)

*

1978-04-24
1979-10-31
Pfizer Inc.
N-(2-thiazolyl)amides and their use as anti-inflammatory and immunoregulatory agents

EP0005070A3
(en)

*

1978-04-24
1979-11-28
Pfizer Inc.
N-(2-thiazolyl)amides and their use as anti-inflammatory and immunoregulatory agents

Also Published As

Publication number
Publication date

JPS50111066A
(en)

1975-09-01

FR2250526A1
(en)

1975-06-06

DE2453147A1
(en)

1975-10-09

SU615858A3
(en)

1978-07-15

US3963735A
(en)

1976-06-15

IL45950A
(en)

1978-01-31

ATA888174A
(en)

1978-05-15

CA1038379A
(en)

1978-09-12

SE7414000L
(en)

1975-05-12

BE822028A
(en)

1975-03-03

ES431804A1
(en)

1976-11-01

DK583974A
(en)

1975-07-07

IL45950A0
(en)

1974-12-31

DD114265A5
(en)

1975-07-20

IN139357B
(en)

1976-06-12

FR2250526B1
(en)

1978-07-28

CH612429A5
(en)

1979-07-31

AT347451B
(en)

1978-12-27

AU7490174A
(en)

1976-05-06

HU168776B
(en)

1976-07-28

DK139723B
(en)

1979-04-02

CS197238B2
(en)

1980-04-30

NL7414519A
(en)

1975-05-13

DK139723C
(en)

1979-11-12

PL95852B1
(en)

1977-11-30

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Acylated 2-aminothiazole derivatives and process for the preparation thereof

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Legal Events

Date
Code
Title
Description

1976-10-20
PS
Patent sealed [section 19, patents act 1949]

1982-06-09
PCNP
Patent ceased through non-payment of renewal fee

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